Hepatitis B Vaccine Side Effects
As with any medication, the hepatitis B vaccine may cause some side effects. Most people dont experience any unwanted effects. The most common symptom is a sore arm from the injection site.
When receiving the vaccination, youll likely receive information or a pamphlet regarding the side effects that you might expect, and others that warrant medical attention.
Mild side effects usually last only . Mild side effects of the vaccine include:
- redness, swelling, or itching at the injection site
- a purple spot or lump at the injection site
Guidance On Reporting Adverse Events Following Immunization
Vaccine providers are asked to report, through local public health officials, any serious or unexpected adverse event temporally related to vaccination. An unexpected AEFI is an event that is not listed in available product information but may be due to the immunization, or a change in the frequency of a known AEFI.
Refer to Reporting Adverse Events Following Immunization in Canada and Adverse events following immunization in Part 2 for additional information about AEFI reporting.
Hepatitis A And Hepatitis B Vaccine Dosing Information
Usual Adult Dose for Hepatitis B Prophylaxis:
Primary immunization: 1 mL IM in the deltoid area at 0, 1 and 6 months.Alternatively, a 4 dose schedule given on days 0, 7, and 21 to 30 followed by a booster at month 12 may be used.
Usual Adult Dose for Hepatitis A Prophylaxis:
Primary immunization: 1 mL IM in the deltoid area at 0, 1 and 6 months.Alternatively, a 4 dose schedule given on days 0, 7, and 21 to 30 followed by a booster at month 12 may be used.
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Hepatitis B Vaccine On The Nhs
A hepatitis B-containing vaccine is provided for all babies born in the UK on or after 1 August 2017. This is given as part of the 6-in-1 vaccine.
Hospitals, GP surgeries and sexual health or GUM clinics usually provide the hepatitis B vaccination free of charge for anyone at risk of infection.
GPs are not obliged to provide the hepatitis B vaccine on the NHS if you’re not thought to be at risk.
GPs may charge for the hepatitis B vaccine if you want it as a travel vaccine, or they may refer you to a travel clinic for a private vaccination. The current cost of the vaccine is around £50 a dose.
Important Information About Vaccine And Hepatitis B Immunoglobulin Shot Administration
Where available, the hepatitis B birth-dose and HBIG should be administered within 24 hours of birth in order to prevent the transmission of hepatitis B from mother to child. It is very important that the shots be given in opposite limbs, to ensure the highest effectiveness. Please see chart above for more information.
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Hepatitis B Vaccination In Pregnancy
Hepatitis B infection in pregnant women may result in severe disease for the mother and chronic infection for the baby.
This is why the hepatitis B vaccine is recommended for pregnant women who are in a high-risk category.
There’s no evidence of any risk from vaccinating pregnant or breastfeeding women against hepatitis B.
And, as it’s an inactivated vaccine, the risk to the unborn baby is likely to be negligible .
How And When Do Doctors Give Vaccines
For the hepatitis A vaccine:
You should get two doses, given as shots, 6 months apart for complete protection. The virus in the vaccine is killed .
Children should get the first dose between 12 and 23 months of age. Children older than age 2 can get the first dose at their next doctorâs visit.
If you need the vaccine because of upcoming travel, get it at least 1 month before you go.
For the hepatitis B vaccine:
For long-lasting immunity, you need three to four doses, depending on which type of vaccine is used. You get them as shots.
Children should get their first dose at birth and complete the series by age 6 months. Usually, the baby would get a second dose at 1 month old and the third dose at 6 months.
Babies born to women who have hepatitis B need a shot of hep B antibodies, as well as their first hep B vaccine shot, when theyâre born. They will also need follow-up blood tests to make sure theyâre OK.
Catch-up vaccinations are recommended for children and teens who were never vaccinated or who did not get all three shots.
If you’re an adult who wants to be vaccinated, you should talk about it with your doctor or pharmacist. If you are considering both vaccines, ask your doctor about vaccines that combine hep A and B.
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Babies And Hepatitis B Vaccination
Pregnant women have a routine blood test for hepatitis B as part of their antenatal care.
Babies born to mothers infected with hepatitis B need to be given a dose of the hepatitis B vaccine within 24 hours of their birth, followed by further doses at 4, 8, 12 and 16 weeks of age, plus a final dose when they’re 1 year old.
Babies of mothers identified by the blood test as particularly infectious might also be given an injection of HBIG at birth on top of the hepatitis B vaccination to give them rapid protection against infection.
All babies born to mothers infected with hepatitis B should be tested at 1 year of age to check if they have become infected with the virus.
Who Should Be Vaccinated With Hepatitis A
- Any person who desires protection from hepatitis A
- Men who have sex with men
- People who use injection or non-injection illegal drugs
- People traveling to areas with a high or intermediate occurrence of hepatitis A
- People with chronic liver disease
- People who receive clotting factor concentrates
- People working with HAV-infected primates or with HAV in a research laboratory
- People who will have close personal contact with an international adoptee during the first 60 days after arriving in the US from a country with a high or intermediate occurrence of hepatitis A
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Vaccines For Hepatitis A And B
Our immune system battles foreign invaders every day, such as when we get a cold virus. When this happens, we develop immunity to that specific virus. This means that our body will fight off the virus if it is ever exposed to it again.
The same protection happens with vaccines. However, the benefit of a vaccination is that you don’t have to go through being sick to enable your body to fight off disease.
Gregory Poland, MD, director of the Mayo Clinic’s Vaccine Research Group, explains that hepatitis vaccinations contain a small amount of the inactive virus. When you get a dose of the vaccine, he says, your immune cells respond by developing immunity against the virus. This immunity lasts over a long period of time.
“So if I get these two doses of hepatitis A vaccine, and then I get exposed 30 years from now, my body will remember that immunity to the vaccine and rapidly start producing antibodies again,” says Poland.
Due to the way hepatitis vaccinations are developed, it is impossible to contract the virus from the vaccine itself, according to Poland.
The hepatitis A vaccine is usually given in two shots and the hepatitis B vaccine is administered as a series of three shots. The most common side effects are redness, pain, and tenderness where the shots are given.
To get long-term protection from these viruses, it’s important to receive all the shots as scheduled. However, if you received one shot and never went back for the others, it’s not too late to catch up.
What Happens If I Miss A Dose
Contact your doctor if you miss a booster dose or if you get behind schedule. The next dose should be given as soon as possible. There is no need to start over.
Be sure you receive all recommended doses of this vaccine. You may not be fully protected against disease if you do not receive the full series.
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People Who Should Get Hepatitis A Vaccine
Practicing good hygiene and frequent hand washing are the best ways to protect against hepatitis A. Hepatitis A vaccine is suggested for the following people:
- All children at age 1
- Patients with chronic liver disease, including hepatitis B or hepatitis C
- Family, caregivers or people in direct contact with others who have hepatitis A
- Men who have sex with men
- People who use any type of illicit drugs
- Chefs who regularly cook foods
- People who work or travel in parts of the world where hepatitis A is common should get vaccination 1 month before traveling.
Vaccination Is The Best Way To Prevent Hepatitis A And B Infection
Narrator: ÂYou are a traveller…Â .
Narrator: …and you are already dreaming of your next getaway. .
Disclaimer on-screen reads: TWINRIX is a combined hepatitis A and hepatitis B vaccine used in adults, adolescents, children, and infants over the age of 1 year to prevent hepatitis A and hepatitis B diseases
Narrator: ÂWhile your travel plans probably donÂt include hepatitis A or hepatitis B…Â .
Disclaimer reads: 100% protection cannot be guaranteed and booster doses may be required.
Narrator: Â…you know that many common travel activities can put you at risk of acquiring these two serious liver diseases…Â .
Disclaimer reads: TWINRIX does not protect against hepatitis C or E, and is not indicated to treat or reduce the severity of hepatitis A or B infections. .
Narrator: Â…which is why you plan on talking to your doctor about TWINRIX, right? … Of course, right…Â Â…because you are a traveller.Â
Video concludes with TWINRIX logo, GSK logo, You are a traveller slogan, and safety information: Very commonly reported adverse events in adults were pain or discomfort, redness at the infection site, headache, and tiredness. Common adverse events were swelling at the injection site, diarrhea, nausea and vomiting, and generally feeling unwell. Allergic reactions may also occur. Full product information can be found on Twinrix.ca. If you need to report an adverse event, please call 1-800-387-7374.
Twinrix.ca
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How Is This Vaccine Given
This vaccine is given as an injection into a muscle. You will receive this injection in a doctor’s office or other clinic setting.
The hepatitis A and B vaccine is given in a series of 3 shots. The booster shots are given 1 month and 6 months after the first shot.
If you have a high risk of hepatitis infection, you may be given 3 shots within 30 days, and a fourth shot 12 months after the first.
Your individual booster schedule may be different from these guidelines. Follow your doctor’s instructions or the schedule recommended by the health department of the state you live in.
What Are The Side Effects Of Hepatitis B/hepatitis A Vaccine
Side effects of hepatitis A/B vaccine are injection site soreness and pain, headache, fatigue, redness, diarrhea, nausea, and fainting. The tip caps of pre-filled syringes may contain latex which can cause allergicreactions in latex-sensitive people. Serious allergic reactions, abnormal heartbeats, and hair loss have also been reported.
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People Who Should Get Hepatitis B Vaccine
Hepatitis B vaccine is recommended for:
- All newborns and children or adolescents who are not vaccinated at birth
- Patients with chronic liver disease
- People who live or have direct contact with someone who has hepatitis B
- Men who have sex with men or people who have multiple sexual partners
- Patients with end-stage kidney disease who need hemodialysis
- Patients who usually require blood transfusion
- People who inject illegal drugs or share needles and syringes
- Travelers or workers planning to go to certain areas of the world with high hepatitis B infection rates
Why Is The Hepb Vaccine Recommended
People who dont know they’re infected can spread the hepatitis B virus. So it cant be avoided just by being careful. That’s why health experts recommend that all babies get the vaccine right from birth.
The HepB injection usually creates long-term immunity. Most infants who get the HepB series are protected from hepatitis B infection beyond childhood, into their adult years.
Eliminating the risk of infection also decreases risk for cirrhosis of the liver, chronic liver disease, and liver cancer.
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What Are The Symptoms Of Hepatitis A And B
Not all infected adults will experience symptoms. That means you could contract hepatitis A or B, and spread the viruses to others, without realizing it.
Symptoms of hepatitis A may include*:
Fever
Jaundice
Loss of appetite
Dark urine
Fatigue
* TWINRIX is not indicated to treat the symptoms of, or reduce serious consequences associated with hepatitis A and B.
Possible consequences of hepatitis A.*Hepatitis A infection can have mild to severe consequences on infected individuals that can last from a few weeks to several months.
Chronic hepatitis and carrier states are not linked with hepatitis A infection.
However, relapsing hepatitis, a condition where a person gets worse again after a period of improvement, can last up to a year in 15% of cases.
While most infected people recover, the older you are, the more severe hepatitis A can be.
Approximately 25% of infected adults are hospitalized.
The overall case fatality rate, which is the proportion of deaths among the number of hepatitis A cases, is approximately 0.5%, but can reach 2.6% in adults over 60 years of age.
* TWINRIX is not indicated to treat the symptoms of, or reduce serious consequences associated with hepatitis A and B.
Symptoms of hepatitis B may include*:
Fatigue
Jaundice
Loss of appetite
Dark urine
Clay-coloured stool
* TWINRIX is not indicated to treat the symptoms of, or reduce serious consequences associated with hepatitis A and B.
Which Adults Should Be Vaccinated Against Hepatitis B
According to CDC recommendations, adults in the following groups are recommended to receive hepatitis B vaccine:
General
- All people age 18 years and younger.
- Anyone 19 years and older who wants to be protected from hepatitis B.
People at risk for infection by sexual exposure
- Sex partners of people who are hepatitis B surface antigen -positive.
- Sexually active people who are not in long-term, mutually monogamous relationships.
- People seeking evaluation or treatment for a sexually transmitted disease.
- Men who have sex with men.
People at risk for infection by percutaneous or permucosal exposure to blood or body fluids
- Current or recent illegal injection drug users.
- Household contacts of people who are HBsAg-positive.
- Residents and staff of facilities for developmentally challenged people.
- Healthcare and public safety workers with reasonably anticipated risk for exposure to blood or blood-contaminated body fluids.
- People with end-stage renal disease, including predialysis, hemo-, peritoneal- and home-dialysis patients.
Others
- International travelers to regions with intermediate or high levels of endemic HBV infection.
- People with chronic liver disease.
- People with HIV infection.
- People with diabetes who are age 19 through 59 years. For those age 60 and older, clinicians should make a determination of need for
- vaccination based on their patients’ situation.
In a future issue, we will review the various hepatitis B serologic tests, who needs testing, and when they need it .
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Indications Dosing And Potential Side Effects
The Twinrix vaccine combines the hepatitis A and hepatitis B vaccine into one syringe.
Learn more about this vaccine, including who should be vaccinated, dosing, and potential side effects based on information from the Centers for Disease Control and Prevention and US Food and Drug Administration.
Which Drugs Or Supplements Interact With Hepatitis B/hepatitis A Vaccine
: Hepatitis A/B vaccine vaccines should not be used with medications and therapies that suppress the immune system such as adalimumab , belimumab , cyclosporine , azathioprine , irradiation, and high doses of steroids because suppressing the immune system reduces the effectiveness of hepatitis A/B vaccine.
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Get To Know Hepatitis B
Hepatitis B is a serious liver infection caused by the hepatitis B virus which is a major cause of chronic liver disease worldwide, especially in Africa and Asia, including Thailand. Chronic hepatitis B is strongly associated with hepatic fibrosis and development of liver cancer. The virus is passed from person to person through blood, semen, saliva or other body fluids. Common routes of transmission that hepatitis B virus can spread are:
- Mother to child during childbirth
- Direct contact with blood or open wound of infected person
- Sexual contact and
- Sharing certain equipment that can spread the virus e.g. needles and toothbrushes. In addition, hepatitis B is a concern for health care workers and anyone else who come in contact with human blood.
Most adults with hepatitis B infection fully recover, although their signs and symptoms are severe. Infants and children are more likely to develop a chronic hepatitis B infection.
Is Hepatitis B/hepatitis A Vaccine Safe To Take If I’m Pregnant Or Breastfeeding
There are no adequate studies done on hepatitis A/B vaccine to determine safe and effective use in pregnant women. Hepatitis A/B vaccine should be given to pregnant women only if clearly needed.
NURSING MOTHERS: It is not known whether hepatitis A/B vaccine enters breast milk therefore, it is best to be cautious before using it in mothers who arebreastfeeding.
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When To Delay Or Avoid Hepb Immunization
Doctors delay giving the vaccine to babies who weigh less than 4 pounds, 7 ounces at birth whose mothers do not have the virus in their blood. The baby will get the first dose at 1 month of age or when the baby is discharged from the hospital.
The vaccine is not recommended if your child:
- is currently sick, although simple colds or other minor illnesses should not prevent immunization
- had a serious allergic reaction after an earlier dose of the vaccine or is allergic to baker’s yeast