Thursday, September 22, 2022

Tenofovir Hepatitis B Side Effects

How Tenofovir Disoproxil Mylan Works In The Treatment Of Chb:

Tenofovir and Entecavir Are the Most Effective Antiviral Agents for Chronic Hepatitis B…

Tenofovir Disoproxil Mylan is used to treat CHB in adults and paediatric patients aged 12 years and older and weighing at least 35 kg.

Tenofovir Disoproxil Mylan works by interfering with the normal working of enzymes that are essential for HBV to reproduce itself. Tenofovir Disoproxil Mylan may help lower the amount of hepatitis B virus in your body by lowering the ability of the virus to multiply and infect new liver cells and can improve the inflammation and scar tissue caused by the hepatitis B virus in your liver.

Lowering the amount of virus in your body may reduce the chance of developing cirrhosis, liver failure and liver cancer.

We do not know how long Tenofovir Disoproxil Mylan may help treat your hepatitis.

Sometimes viruses change in your body and medicines no longer work. This is called drug resistance.

Approved Drugs For Adults

There are currently 7 approved drugs in the United States for adults living with chronic hepatitis B infection. These include 5 types of antiviral drugs that are taken as a pill once a day for 1 year or longer. And there are 2 types of immune modulator drugs called interferon that are given as an injection for 6 months to 1 year.

It is important to know that not everyone needs to be treated. A liver specialist should evaluate your health through a physical exam, blood tests, and an imaging study of your liver . Then you can discuss together whether you are a good candidate for treatment since the approved drugs are most effective when there are signs of active liver disease. In addition, talk to your provider about HBV Clinical Trials since there are several new drugs being tested that are available for infected adults.

All adults, however, should be seen regularly by a liver specialist whether they are on treatment or not.

What Side Effects May I Notice From Receiving This Medicine

Side effects that you should report to your doctor or health care professional as soon as possible: -allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue -bone pain -muscle pain -nausea, vomiting, unusual upset stomach or stomach pain -signs and symptoms of kidney injury like trouble passing urine or change in the amount of urine -signs and symptoms of liver injury like dark yellow or brown urine general ill feeling or flu-like symptoms light-colored stools loss of appetite nausea right upper belly pain unusually weak or tired yellowing of the eyes or skin -signs of infection – fever or chills, cough, sore throat, pain or trouble passing urineSide effects that usually do not require medical attention : -cough

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Where Should I Keep My Medicine

Keep out of the reach of children.

Store at room temperature between 15 to 30 degrees C . Keep this medicine in the original container. Throw away any unused medicine after the expiration date.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.

What May Interact With This Medicine

Optimizing the Management of Hepatitis B and C

Do not take this medicine with any of the following medications: – adefovir – certain antiviral medicines for HIV or AIDS like emtricitabine tenofovir or emtricitabine rilpivirine tenofovir or efavirenz emtricitabine tenofovir or cobicistat elvitegravir emtricitabine tenofovirThis medicine may also interact with the following medications: –

Visit your doctor or health care professional for regular check ups. Discuss any new symptoms with your doctor. You will need to have important blood work done while on this medicine.Hepatitis B and HIV are spread to others through sexual or blood contact. Talk to your doctor about how to stop the spread of hepatitis B and HIV.If you have hepatitis B, talk to your doctor if you plan to stop this medicine. The symptoms of hepatitis B may get worse if you stop this medicine.Using this medicine for a long time may increase your risk of low bone mass. Talk to your doctor about bone health.

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Who Must Not Take It

Together with your doctor, you need to decide whether Tenofovir Disoproxil Mylan is right for you.

Do not take Tenofovir Disoproxil Mylan if:

  • you are allergic to tenofovir disoproxil maleate, tenofovir disoproxil fumarate or any of its ingredients
  • you are already taking a combination tablet containing tenofovir disoproxil maleate or tenofovir disoproxil fumarate
  • you are already taking adefovir dipivoxil to treat hepatitis B virus infection

How To Use Tenofovir Alafenamide Fumarate Tablet

Before starting treatment with this medication, your doctor should test you for HIV infection. If you have HIV infection along with hepatitis B infection, tenofovir alafenamide should not be used alone since this may make it harder to treat your HIV infection. Combination drug treatment should always be used to treat HIV infection.

Read the Patient Information Leaflet if available from your pharmacist before you start taking tenofovir alafenamide, and each time you get a refill. If you have any questions, ask your doctor or pharmacist.

Take this medication by mouth with food as directed by your doctor, usually once daily.

If you are on dialysis, on your dialysis days, take your daily dose of this medication following dialysis.

The dosage is based on your medical condition, response to treatment, and other medications you may be taking. Be sure to tell your doctor and pharmacist about all the products you use .

For the best effect, take this medication at evenly spaced times. To help you remember, take this medication at the same time every day.

If you vomit within 1 hour after taking a dose, take another dose of this medication. If vomiting occurs more than 1 hour after taking your dose, do not take another dose. Take your next dose at the regular time.

Do not take more or less of this drug than prescribed or stop taking it even for a short time unless directed to do so by your doctor. Doing so may make the infection worse or harder to treat , or worsen side effects.

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Before Taking This Medicine

You should not take tenofovir if you are allergic to it.

Do not take tenofovir together with adefovir , or with combination medicines that contain tenofovir .

Tell your doctor if you have ever had:

You may develop lactic acidosis, a dangerous build-up of lactic acid in your blood. Ask your doctor about your risk.

To prevent HIV in a newborn baby, use all medications to control your infection during pregnancy. Your name may be listed on an antiviral pregnancy registry.

Women with HIV should not breastfeed. The virus can pass to your baby in your breast milk.

How Should I Take Tenofovir Disoproxil Fumarate

Lamivudine, Tenofovir, and Adefovir – Treatment of Hepatitis B

Tenofovir DF comes in the following forms and strengths:

  • 150-mg, 200-mg, 250-mg, and 300-mg tablets
  • Oral powder

Take tenofovir DF according to your health care provider’s instructions.

Tenofovir DF tablets should be swallowed whole and can be taken with or without food. People who are unable to swallow the tablets whole may take the oral powder. Use the provided dosing scoop to measure the oral powder. Mix the oral powder with soft foods that can be swallowed without chewing, such as applesauce, baby food, or yogurt. Do not mix the oral powder with liquid, as the powder may float to the top even after stirring. Take the dose of oral powder right after mixing it.

Always take tenofovir DF in combination with other HIV medicines.

If you have taken too much tenofovir DF, contact your health care provider or local poison control center right away, or go to the nearest hospital emergency room.

For more information on how to take tenofovir DF, see the FDA drug label.

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Demographic And Clinical Baseline Characteristics Of The Study Population

We screened 125 ACLF patients during this period, and 88 HBV-related ACLF people were identified. The following patients were excluded:1 patient was treated with lamivudine, 4 patients with combination treatment of two antiviral agents, 10 received 1.0mg entecavir daily and 3 died within 2days after admission. Finally, gender and age matched 10 patients with TAF, 10 with TDF and 20 with ETV treatment were enrolled . They were prospectively followed-up regularly till death or end of the study.

Fig. 1

Patient disposition during the study. ACLF, acute-on-chronic liver failure LAM, lamivudine ETV, entecavir TDF, tenofovir disoproxil fumarate TAF, tenofovir alafenamide

The primary baseline demographics and disease characteristics were summarized in Table . There were no significant differences among three groups in the baseline characteristics of age, gender, serum ALT, AST, WBC, PLT, albumin, urea, creatinine, sodium, eGFR, HBV DNA viral load, CTP score, MELD score, and complications.

Table 1 Baseline characteristics of the study population

What Side Effects Can Tenofovir Disoproxil Fumarate Cause

Tenofovir DF may cause side effects. Some side effects of tenofovir DF can be serious as noted above. Many side effects from HIV medicines, such as nausea or occasional dizziness, are manageable. See the HIVinfo fact sheet on HIV Medicines and Side Effects for more information.

Other possible side effects of tenofovir DF include:

  • Changes in your immune system . IRIS is a condition that sometimes occurs when the immune system begins to recover after treatment with an HIV medicine. As the immune system gets stronger, it may have an increased response to a previously hidden infection.
  • Bone problems, including bone pain, or softening or thinning of the bones , which may lead to fractures.

Tell your health care provider if you have any side effect that bothers you or that does not go away.

These are not all the possible side effects of tenofovir DF. To learn more about possible side effects of tenofovir DF, read the drug label or package insert or talk to your health care provider or pharmacist.

You can report side effects to FDA at 1-800-FDA-1088 or online.

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Can I Take Tenofovir If Im Pregnant Or Breastfeeding

Tell your doctor if you are pregnant, and use your medications properly to control your infection. HIV can be passed to your baby if the virus is not controlled during pregnancy. Your name may be listed on a registry to track any effects of antiviral medicine on the baby.

Women with HIV or AIDS should not breast feed a baby. Even if your baby is born without HIV, the virus may be passed to the baby in your breast milk.

Frequently Asked Questions About Vemlidy

Tenofovir better than entecavir in acute

Is Vemlidy better than Viread?

Vemlidy and TDF are both good medications for HIV and hepatitis B. Vemlidy is safer for the kidneys and bones, but can raise your cholesterol when compared to TDF .

Can Vemlidy cure hepatitis B?

There is currently no cure for hepatitis B, only treatment options to help manage symptoms. Medications such as Vemlidy can lower the amount of hepatitis B virus in your liver so there’s less risk of liver damage.

How long do you take Vemlidy ?

You should continue to take Vemlidy for as long as your provider tells you to. Depending on lab results and liver function, some people may take Vemlidy for a few years, while others will be on the medication for life. Stopping Vemlidy too early can lead to a flare-up of hepatitis B, which can harm your liver.

When should I take Vemlidy ?

Vemlidy can be taken at any time of the day. It needs to be taken with food, so it’s best to choose a time of the day when you regularly eat and will remember to take your medication.

When did Vemlidy come out?

Vemlidy was approved by the FDA on November 10, 2016. The active ingredient, tenofovir alafenamide , was first used in the HIV antiretroviral combination medication Genvoya in 2015.

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What Should I Discuss With My Healthcare Provider Before Taking Tenofovir

You should not take tenofovir if you are allergic to it.

Do not take tenofovir together with adefovir , or with combination medicines that contain tenofovir .

Tell your doctor if you have ever had:

You may develop lactic acidosis, a dangerous build-up of lactic acid in your blood. This may be more likely if you have other medical conditions, if you’ve taken HIV medication for a long time, or if you are a woman. Ask your doctor about your risk.

Tell your doctor if you are pregnant, and use your medications properly to control your infection. HIV can be passed to your baby if the virus is not controlled during pregnancy. Your name may be listed on a registry to track any effects of antiviral medicine on the baby.

It may not be safe to breast-feed while using this medicine. Ask your doctor about any risk. Women with HIV or AIDS should not breast feed a baby. Even if your baby is born without HIV, the virus may be passed to the baby in your breast milk.

How To Use Tenofovir Disoproxil Fumarate Oral

Read the Patient Information Leaflet if available from your pharmacist before you start taking tenofovir, and each time you get a refill. If you have any questions regarding the information, consult your doctor or pharmacist.

Take this medication by mouth with or without food as directed by your doctor, usually once daily.

The dosage is based on your medical condition, kidney function, and response to treatment. For children, the dosage is also based on weight.

It is very important to continue taking this medication exactly as prescribed by your doctor. Do not skip any doses. Do not increase your dose, take this drug more often than prescribed, or stop taking it even for a short time unless directed to do so by your doctor. Skipping or changing your dose without approval from your doctor may cause the amount of virus to increase, make the infection more difficult to treat , or worsen side effects.

For the best effect, take this medication at evenly spaced times. To help you remember, take this medication at the same time every day.

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Why Is This Medication Prescribed

Tenofovir is used along with other medications to treat human immunodeficiency virus infection in adults and children 2 years of age and older. Tenofovir is also used to treat chronic HBV in adults and children 2 years of age and older weighing 22 pounds or more. Tenofovir is in a class of medications called nucleoside reverse transcriptase inhibitors . It works by decreasing the amount of HIV and HBV in the blood. Although tenofovir will not cure HIV, it may decrease your chance of developing acquired immunodeficiency syndrome and HIV-related illnesses such as serious infections or cancer. Taking these medications along with practicing safer sex and making other lifestyle changes may decrease the risk of transmitting the HIV virus to other people. Tenofovir will not cure hepatitis B and may not prevent complications of chronic hepatitis B such as cirrhosis of the liver or liver cancer. Tenofovir may not prevent the spread of hepatitis B to other people.

How To Take Tenofovir Disoproxil Mylan

Treatment of Hepatitis Part 3 – Hepatitis B (HBV) Treatment

Stay under a doctor’s care when taking Tenofovir Disoproxil Mylan.

Do not change your treatment or stop treatment without first talking with your doctor.

Take Tenofovir Disoproxil Mylan exactly as your doctor prescribed it.

Follow the directions from your doctor or pharmacist, exactly as written on the label.

Set up a dosing schedule and follow it carefully.

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Study Design And Participants

From January 2019 to December 2019, consecutive HBV-related ACLF patients treated with TAF, TDF or ETV monotherapy in the First Affiliated Teaching Hospital of Xian Jiaotong University, the biggest general hospital in northwest China under the direct administration of the Chinese Ministry of Health, were recruited in this study. The inclusion criteria were: age 1870years Hepatitis B surface antigen positive6months ACLF was diagnosed according to the diagnostic criteria recommended by the Asian Pacific Association for the Study of the Liver . Patients were excluded if they had any of the following conditions: concomitant hepatitis A, C, D, E virus, or other hepadnaviruses infections malignancies, such as hepatocellular carcinoma with one or more additional known primary or secondary causes of liver disease, other than hepatitis B.

During hospitalization, antiviral therapy with TAF, TDF or ETV was started immediately when HBV-DNA was tested positive. Adverse side effects were carefully monitored during the study period. All patients were given standard medical treatment, including absolute bed rest, supportive care, energy supplements and vitamins. Therapeutic plasma exchange or double plasma molecular absorption system were administered for patients at doctors discreet decision.

What Is The Most Important Information I Should Know About Tenofovir

You should not take tenofovir if you are allergic to it.

Do not take tenofovir together with adefovir , or with combination medicines that contain tenofovir .

Tell your doctor if you have ever had:

  • liver disease
  • HIV
  • kidney disease or
  • low bone mineral density.

You may develop lactic acidosis, a dangerous build-up of lactic acid in your blood. This may be more likely if you have other medical conditions, if you’ve taken HIV medication for a long time, or if you are a woman. Ask your doctor about your risk.

Tell your doctor if you are pregnant, and use your medications properly to control your infection. HIV can be passed to your baby if the virus is not controlled during pregnancy. Your name may be listed on a registry to track any effects of antiviral medicine on the baby.

Women with HIV or AIDS should not breast feed a baby. Even if your baby is born without HIV, the virus may be passed to the baby in your breast milk.

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