Thursday, July 18, 2024

Dosage Of Hepatitis B Vaccine

What Hepatitis B Immunisation Involves

Ending hepatitis B with crucial birth dose vaccine

Full protection involves having 3 injections of the hepatitis B vaccine at the recommended intervals.

Babies born to mothers with hepatitis B infection will be given 6 doses of hepatitis B-containing vaccine to ensure long-lasting protection.

If you’re a healthcare worker or you have kidney failure, you’ll have a follow-up appointment to see if you have responded to the vaccine.

If you have been vaccinated by your employer’s occupational health service, you can request a blood test to see if you have responded to the vaccine.

How Is The Vaccine Given

Engerix-B® and Recombivax HB® are given in 3 or 4 shots over a 6-month period. Infants should get their first dose at birth and usually complete the series by 6 months of age. Older children and teenagers who were not vaccinated as infants should also be vaccinated, as well as unvaccinated adults who are at risk of infection with hepatitis B.

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Dosage And Vaccination Schedule

Dosage varies according to age and type of vaccine used: follow manufacturer’s instructions.

Child: one dose = 5 to 10 micrograms

Adult: one dose = 10 to 20 micrograms

  • Standard schedule
  • Neonate and infant:
  • One dose as soon as possible after birth then a 2nd dose at 6 weeks and a 3rd dose at 14 weeks
  • One dose as soon as possible after birth then 3 doses administered 4 weeks apart with the 1st at 6 weeks, the 2nd at 10 weeks and the 3rd at 14 weeks
  • Child, adolescent, adult: schedule 0-1-6

2 doses 4 weeks apart, then a 3rd dose 6 months after the 1st dose

  • Accelerated schedule, when rapid protection is required in the event of post-exposure prophylaxis

3 doses administered during the same month on D0-D7-D21, then a 4th dose one year after the 1st dose

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How To Prevent Hepatitis B Infections

Now that we know the risks associated with Hepatitis B, lets get to the good news. The transmission of this disease is almost entirely preventable by vaccination.

The Hepatitis B vaccine, first available in 1982, is 98 to 100% successful in preventing an infection. The World Health Organization has set a goal to eliminate viral Hepatitis by the year 2030 and has provided guidelines that have been adopted in several countries. Vaccination is one of the most important and efficient ways to decrease the burden of this disease. Taking the vaccine is especially important for people who are at high risk of developing the infection.

Routine Administration Schedule For Hepatitis B Vaccine In Adults

  • The dosing schedule is 0, 1 to 2 months, and 4 to 6 months.
  • There is some flexibility in the schedule, but be sure to keep in mind the minimum intervals between doses:
    • At least four weeks between doses #1 and #2
    • At least eight weeks between doses #2 and #3
    • At least 16 weeks between doses #1 and #3
  • If your patient falls behind on the hepatitis B vaccination schedule , continue vaccinating from where your patient left off. The series does NOT need to be restarted.

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Us Infant Hepatitis B Vaccine Schedules

*Please note that the first dose should be given as soon as possible. Additional doses require minimum time intervals between doses in order for the vaccine to be effective.
3-Dose Vaccine Series for Infants

Since 1991, ALL medically stable infants with a birth weight of at least 2,000 g in the U.S. are recommended to receive the first dose of hepatitis B vaccine within 24 hours of birth. The additional 2 doses are given at 1 month and 6 months of age.

4-Dose Vaccine Combination Series for Infants

Combination vaccines, such as the pentavalent and hexavalent vaccines, include protection against 5 or 6 diseases, including hepatitis B. The first shot is usually given at 6 weeks of age, but in order to protect infants from hepatitis B beginning at birth, a monovalent or single dose of the hepatitis B vaccine is also recommended within 24 hours of birth. The hepatitis B vaccine series can then be completed with the pentavalent or hexavalent vaccine with the recommended schedule.

How Common Is Hepatitis B

One U.S. study following trends in hepatitis B infection over a three-year periodfound that 4.3% of the population had a past or present HBV infection.

Estimates suggest that about 240 million people around the world have chronic hepatitis B. Up to 1.89 million people in the United States have a chronic HBV infection.

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For Adults And Children

This vaccine schedule involves three doses within 2 months, followed by a booster dose at 1 year.

The initial accelerated doses provide immediate protection from HBV, and the booster dose helps provide long-term protection.

Below is the accelerated vaccination schedule approved for both adults and children:

Vaccine series
2 months after the first dose 1 year after the first dose

What Are Side Effects Of Inactivated Viral Vaccines

Hepatitis B Vaccine

Side effects of inactivated viral vaccines may include the following:

  • Injection site reactions include:
  • Triggering of shingles in pre-exposed individuals
  • Precipitation or aggravation of autoimmune disorders such as multiple sclerosis
  • Information contained herein is not intended to cover all possible side effects, precautions, warnings, drug interactions, allergic reactions, or adverse effects. Check with your doctor or pharmacist to make sure these drugs do not cause any harm when you take them along with other medicines. Never stop taking your medication and never change your dose or frequency without consulting your doctor.

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    Hepatitis B Vaccination In Pregnancy

    Hepatitis B infection in pregnant women may result in severe disease for the mother and chronic infection for the baby.

    This is why the hepatitis B vaccine is recommended for pregnant women who are in a high-risk category.

    There’s no evidence of any risk from vaccinating pregnant or breastfeeding women against hepatitis B.

    And, as it’s an inactivated vaccine, the risk to the unborn baby is likely to be negligible .

    Why Should I Vaccinate My Newborn Child If I Know That I Am Not Infected With Hepatitis B Virus

    Before the hepatitis B vaccine, every year in the United States about 18,000 children were infected with hepatitis B virus by the time they were 10 years old. This statistic is especially important because people are much more likely to develop liver cancer or cirrhosis if they are infected early in life, rather than later in life .

    About 9,000 of the 18,000 children infected in the first 10 years of life caught the virus from their mother during birth. However, many young children didn’t catch the disease from their mother. They caught it from either another family member or someone else who came in contact with the child. Because hepatitis B can be transmitted by relatively casual contact with items contaminated with the blood of an infected person, and because many people who are infected with hepatitis B virus don’t know that they have it, it is virtually impossible to be “careful enough” to avoid this infection.

    For these reasons, all young children are recommended to receive the hepatitis B vaccine. The best time to receive the first dose is right after birth. This will ensure that the child will be protected as early as possible from catching hepatitis B from people who dont know that they are infected with the virus.

    Listen to Dr. Offit explain why newborns get the hepatitis B vaccine by watching this short video, part of the series Talking About Vaccines with Dr. Paul Offit.

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    Does The Hepatitis B Vaccine Have Side Effects

    Some children will develop pain or soreness in the local area of the shot, and low-grade fever.

    There is one extremely rare, but serious, side effect. About 1 out of every 600,000 doses of the hepatitis B vaccine will cause a severe allergic reaction, called anaphylaxis, with symptoms including swelling of the mouth, difficulty breathing, low blood pressure or shock. Anaphylaxis usually occurs within 15 minutes of receiving the vaccine. Although anaphylaxis can be treated, it is quite frightening. People should remain at the doctors office for about 15 minutes after getting the vaccine.

    Although the hepatitis B vaccine is made in yeast cells, no one has ever been shown to be allergic to the yeast proteins contained in the hepatitis B vaccine .

    Infants Born To Mothers Who Have Hepatitis B: Hepatitis B Vaccine Schedules

    Hepatitis B. Immune Globulin, Hep B Vaccine,     in ...
    *Please note that the first dose should be given as soon as possible. Additional doses require minimum time intervals between doses in order for the vaccine to be effective.

    Protecting Your Baby

    Infants born to women with hepatitis B must receive accurate doses of hepatitis B vaccine and hepatitis B immune globulin to ensure complete protection. In order to protect these infants, medications should be given immediately after birth in the delivery room or within the first 12-24 hours of life*.

    * See Testing and Treatment During Pregnancy section for details. Please note that testing of all pregnant women for hepatitis B is a global recommendation.

    3-Dose Vaccine Series for Infants

    The World Health Organization recommends that infants born to hepatitis B positive mothers receive the first dose of the hepatitis B vaccine within 24 hours of birth, and ideally a dose of hepatitis B immunoglobulin . These shots must be followed by the additional vaccine doses given on the recommended schedule. In the U.S., infants should follow a 1 month and 6-month schedule for the additional two doses.

    4-Dose Combination Vaccine Series for Infants

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    What Else Should I Know About Hepatitis B/hepatitis A Vaccine

    What preparations of hepatitis B/hepatitis A vaccine are available?


    • Hepatitis A/B vaccine is available as sterile, preservative-free, intramuscular injections.
    • Hepatitis A/B vaccine injections are available in 1 ml single-dose vials and 1 ml single-dose pre-filled disposable syringes.
    • Each 1 ml dose of vaccine contains 720 ELISA Units of inactivated Hepatitis A virus and 20 mcg of recombinant Hepatitis B antigen protein.
    How should I keep hepatitis B/hepatitis A vaccine stored?

    Store hepatitis A/B vaccine under refrigeration between 2 C and 8 C . Do not freeze hepatitis A/B vaccine vaccines and discard if they have been frozen.

    Are There Any Side Effects Associated With Combination Vaccines

    These vaccines are very tolerable or have very mild side effects. You wont need to be worried about mild symptoms like pain and swelling in the area where the shot has been given. On the other hand, if your child takes individual shots then, they will have to go through the pain and swelling multiple times, and thus, combination vaccines are preferred. The side effects that can come with it include swelling, pain, or fever that can last 2-3 days. In some cases, doctors can prescribe medication to ease the symptoms. We must make sure that you are following all the instructions carefully for the vaccine to be effective.

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    Who Should Get The Hbv Vaccine

    The Centers for Disease Control and Prevention recommends that all children and adults up to age 59 should receive the hepatitis B vaccine.

    Infants should get their first hepatitis B vaccine within 24 hours of birth and complete their doses by age 6 to 18 months.

    All unvaccinated children and adults through age 59 should receive the vaccine. Also, unvaccinated adults over the age 60 who are at risk of hepatitis B should get the vaccine.

    Adults over age 60 who are not at risk of hepatitis B may also choose to get the shot.

    Several types of the HBV vaccine are also safe to administer to pregnant women.

    • people who have had more than one sex partner in the last 6 months
    • men who have sex with men
    • people seeking treatment for a sexually transmitted infection
    • people whose partners or household members have hepatitis B
    • people who inject drugs
    • people who live or work in care facilities
    • people who are on dialysis
    • travelers to countries where hepatitis B is common
    • people with chronic liver disease, HIV, or hepatitis C
    • people who are in jail or prison

    People who have diabetes should talk with a healthcare professional about their risk for contracting hepatitis B.

    Why Should My Baby Get The Hepatitis B Shot

    Pediatrics Hepatitis B A Vaccination Vaccine Jaundice Immunization Schedule Dose
    • Protects your child from against hepatitis B, a potentially serious disease.
    • Protects other people from the disease because children with hepatitis B usually dont have symptoms, but they may pass the disease to others without anyone knowing they were infected.
    • Prevents your child from developing liver disease and cancer from hepatitis B.
    • Keeps your child from missing school or child care and you from missing work.

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    Immunisation Against Hepatitis B For Children

    Vaccination is the best protection against hepatitis B infection and is recommended for all infants and young children, adolescents and those in high-risk groups. Vaccination can be with a vaccine against hepatitis B alone or with a combination vaccine.

    Protection against hepatitis B is available free of charge under the National Immunisation Program Schedule.

    In Victoria, vaccination against hepatitis B is free for all babies and children including:

    • Babies at birth vaccinate with hepatitis B vaccine as soon as possible after birth.
    • Babies at 2, 4 and 6 months immunisation in the form of a diphtheria, tetanus, whooping cough, hepatitis B, polio and Haemophilus influenzae type b vaccine .
    • Premature babies at 12 months premature babies born under 32 weeks gestation or under 2,000g birth weight receive a single booster dose.
    • Children up to and including 20 years of age.

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    Us Children And Adult Hepatitis B Vaccine Schedules

    *Please note that the first dose should be given as soon as possible. Additional doses require minimum time intervals between doses in order for the vaccine to be effective.

    3-Dose Vaccine Series for Children and Adults

    The hepatitis B vaccine is an injection that is generally given in the arm as a three-dose series on a 0, 1, and 6-month schedule. Alternative schedules may be considered, noting that a third dose at 6 months, meeting minimum intervals between doses, is needed for maximum, long-term protection. Completing the hepatitis B vaccine series, preferably beginning at birth, will ensure protection against hepatitis B, hepatitis delta and lower the lifetime risk of liver cancer. Greater than 90% of babies and up to 50% of young children who are not vaccinated and are infected with hepatitis B will have lifelong infection, which makes the birth dose essential to their protection.

    There are four, 3-dose vaccine brands approved in the U.S.

    • PreHevbrio PreHevbrio is only approved for adults age 18 and over.

    2-Dose Vaccine Series

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    Schedule Of The Hepatitis B Vaccine

    The Indian Academy of Paediatrics recommends that in newborns, the first dose of the Hepatitis B vaccine should be administered immediately after birth or within 24 hours. The second and third doses are at 6 and 14 weeks respectively. In case the birth dose is missed, three doses of the vaccine at 6, 10, and 14 weeks are recommended.

    The Hepatitis B vaccine affords lifetime protection once administered. The routine assessment of antibodies in the blood after vaccination is not recommended. However, if you are a member of a high-risk group, your doctor may recommend that you measure the antibody levels in your blood to make sure you remain protected by the vaccine.

    What Are The Side Effects Of Hepatitis B/hepatitis A Vaccine

    Hepatitis B Vaccine, Packaging Type: Glass Bottle , for Clinical,

    Side effects of hepatitis A/B vaccine are injection site soreness and pain, headache, fatigue, redness, diarrhea, nausea, and fainting. The tip caps of pre-filled syringes may contain latex which can cause allergicreactions in latex-sensitive people. Serious allergic reactions, abnormal heartbeats, and hair loss have also been reported.

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    How Is The Hepatitis B Vaccine Made

    People are protected against hepatitis B virus infection by making an immune response to a protein that sits on the surface of the virus. When hepatitis B virus grows in the liver, an excess amount of this surface protein is made. The hepatitis B vaccine is made by taking the part of the virus that makes surface protein and putting it into yeast cells. The yeast cells then produce many copies of the protein that are subsequently used to make the vaccine. When the surface protein is given to children in the vaccine, their immune systems make an immune response that provides protection against infection with the hepatitis B virus.

    The first hepatitis B vaccine was made in the 1980s by taking blood from people infected with hepatitis B virus and separating or purifying the surface protein from the infectious virus. Because blood was used, there was a risk of contaminating the vaccine with other viruses that might be found in blood, such as HIV. Although contamination with HIV was a theoretical risk of the early, blood-derived hepatitis B vaccine, no one ever got HIV from the hepatitis B vaccine. That is because the blood used to make vaccine was submitted to a series of chemical treatments that inactivated any possible contaminating viruses. Today, there is no risk of contaminating the vaccine with other viruses because the surface protein is manufactured in the laboratory.

    Dosage Forms & Strengths


    • belimumab

      belimumab decreases effects of hepatitis b vaccine by immunosuppressive effects risk of infection. Contraindicated. Do not administer live vaccines 30 days before or concurrently with belimumab.

    Serious – Use Alternative

    Monitor Closely


    • chloroquine decreases effects of hepatitis b vaccine by pharmacodynamic antagonism. Minor/Significance Unknown.

    • ozanimod

      ozanimod decreases effects of hepatitis b vaccine by immunosuppressive effects risk of infection. Minor/Significance Unknown. No clinical data are available on the efficacy and safety of vaccinations in patients taking ozanimod. Vaccinations may be less effective if coadministered with ozanimod.

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