Monday, June 27, 2022

What Are The Side Effects Of Hepatitis C

Getting Tested For Hepatitis C

Managing Hepatitis C Treatment Side Effects in the Interferon Era

Seek medical advice if you have persistent symptoms of hepatitis C or there’s a risk you’re infected, even if you do not have any symptoms.

A blood test can be carried out to see if you have the infection.

GPs, sexual health clinics, genitourinary medicine clinics or drug treatment services all offer testing for hepatitis C.

Early diagnosis and treatment can help prevent or limit any damage to your liver, as well as help ensure the infection is not passed on to other people.

Possible Complications Of Hepatitis C

Theres one main complication of acute hepatitis C: It could become chronic.

If you go on to develop chronic hepatitis C, you could eventually experience a number of health complications, including:

  • Cirrhosis. With cirrhosis, scar tissue gradually replaces healthy tissue in your liver, blocking blood flow and disrupting liver function. Cirrhosis can eventually lead to liver failure.
  • Liver cancer. Having chronic hepatitis C raises your risk for eventually developing liver cancer. If you develop cirrhosis or your liver is very damaged before treatment, youll still have a higher risk for cancer after getting treated.
  • Liver failure. It takes a long time for your liver to fail. Liver failure, or end-stage liver disease, happens slowly over months, often years. When your liver becomes unable to function properly, youll need a transplant.

If you believe you contracted the hepatitis C virus, a good next step involves reaching out to a healthcare professional. Getting timely treatment can lower your risk for experiencing serious complications.

The sooner you get a diagnosis, the sooner your healthcare professional can start a treatment plan.

research continues.

Currently, the best way to protect yourself from the hepatitis C virus is to avoid using any items that may have come into contact with someone elses blood.

You can do this by:

Current Antiviral Treatment Strategies

The introduction of DAA revolutionized the field of antiviral therapy for patients chronically infected with HCV. Antiviral therapy usually consists of at least two antiviral substances from different drug classes with different modes of action . Treatment decisions are based on genotype , presence of cirrhosis and response to prior treatments . Typical treatment regimens for patients with and without compensated cirrhosis are depicted in Tables 1 and 2. All different recommended regimens achieve SVR rates of more than 95% if administered correctly .

Table 1.

Treatment of patients with chronic hepatitis C without cirrhosis

Table 2.

Treatment of patients with chronic hepatitis C with compensated cirrhosis

Fig. 1.

The replication cycle of the hepatitis C virus and modes of action of direct-acting antivirals are displayed .

The pangenotypic drug combinations sofosbuvir/velpatasvir and glecaprevir/pibrentasvir show high antiviral efficacy against all HCV genotypes. Treatment duration differs from 8 weeks for glecaprevir/pibrentasvir in noncirrhotic treatment-naive patients to 12 weeks for patients with liver cirrhosis or 16 weeks for GT 3 patients with liver cirrhosis and/or prior treatment failure. Sofosbuvir/velpatasvir has to be administered for 12 weeks independently of fibrosis level . Treatment with grazoprevir/elbasvir is possible in patients with GT 1 or 4 infection and has to be administered for 1216 weeks depending on GT, fibrosis stage and viral load .

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Tips And Remedies To Help With Side Effects

There are things you can do to ease many of the side effects from hepatitis C treatment.

  • If fever or aches start a few hours after your interferon shot, try getting the shot at bedtime. Take acetaminophen or ibuprofen about 30-60 minutes before your shot. Check with your doctor about which would be best for you.
  • If you start to feel depressed, talk to your doctor. They might prescribe an antidepressant. Exercise can also boost your mood. For anxiety or crankiness, exercise regularly, get plenty of sleep, and try relaxation exercises like yoga or tai chi.
  • If you have stomach problems, take your medications with food. Eat smaller, healthier meals and skip spicy, acidic foods. Ask your doctor about medications that might help ease nausea or diarrhea.
  • Use moisturizing soaps and lotions to help with dry skin. Don’t take long, hot showers or baths.
  • For a dry mouth or sour mouth, brush your teeth often and suck on sugar-free candies. Drink lots of water.
  • Remember that these side effects will typically go away once you’re cured, so stick with your treatment. Work with your doctor on your treatment plan so that you can manage any problems and try to get the virus out of your body as soon as possible

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    What Are The Treatments For Hepatitis C

    Ribavirin Long

    Treatment for hepatitis C is with antiviral medicines. They can cure the disease in most cases.

    If you have acute hepatitis C, your health care provider may wait to see if your infection becomes chronic before starting treatment.

    If your hepatitis C causes cirrhosis, you should see a doctor who specializes in liver diseases. Treatments for health problems related to cirrhosis include medicines, surgery, and other medical procedures. If your hepatitis C leads to liver failure or liver cancer, you may need a liver transplant.

    Also Check: What Are The First Symptoms Of Hepatitis C

    What Is The Prognosis For Someone Who Has Hepatitis C

    You can continue to lead an active life even if you are diagnosed with hepatitis C. People with the disease can work and continue their regular daily activities. However, it is very important that you see a specialist as soon as you are diagnosed with hepatitis C. There are many treatments available that can cure the virus.

    To maintain a healthy lifestyle, patients should:

    Treatment Of Patients With Prior Daa Treatment Failure

    After failure of DAA treatment, the development of RAS is very likely. RAS linked to the NS5A gene are more likely to persist for a longer time at a significant level than those connected to the NS3/4 gene. RAS relevant for the NS5B inhibitor sofosbuvir are usually rapidly suppressed after treatment cessation due to a significantly impaired viral fitness. Resistance testing and the adaptation of antiviral regimes according to RAS is one possible option for retreatment . Currently, the only approved drug combination for the retreatment of patients with prior DAA failure is the combination of sofosbuvir, velpatasvir and voxilaprevir . This combination is not only well tolerated, but also highly effective, and SVR rates > 95% can be achieved in pretreated patients independently from the initial treatment regimen . The recommended treatment duration for DAA-experienced patients is 12 weeks . Preliminary real-world data confirmed the high efficacy of the SOF/VEL/VOX in previous DAA failures. All of the first 110 patients who had completed SOF/VEL/VOX in the German Hepatitis C Registry achieved SVR . Excellent results have also been reported from French and US cohorts . Due to its effectiveness this combination should be reserved for the retreatment of patients with prior DAA failure and is usually not recommended for the initial treatment of therapy-naive patients .

    Also Check: Best Medicine For Hepatitis B

    What Makes Yale Medicine’s Approach To Treating Hepatitis B And C Unique

    The Viral Hepatitis Program at Yale Medicine represents one of the leading viral hepatitis treatment programs in the country and is engaged in innovative research focused on advancing the care of patients with chronic hepatitis B, C and D infections.

    A multidisciplinary team of faculty physicians and mid-level providers offer a coordinated approach to preparing patients for success with antiviral therapy, including comprehensive laboratory testing services to characterize your infection, non-invasive liver fibrosis testing with techniques such as FibroScan liver elastography, structured hepatitis patient education classes, mindfulness-based stress reduction techniques , a formal physician-guided weight-loss program and access to clinical trials evaluating current and new therapies that are not available in routine clinical practice. Our program is a core member of several national and international observational cohort studies which contributes to the advancement of science of hepatitis treatment around the world.

    What Is The Cost Of Hepatitis C Treatment In India

    The Truth about Hepatitis C Treatment long term Side Effects

    Hepatitis C treatment is extremely costly. A full course of medicines and medications can cost about INR 4, 00,000. Apart from these, the drugs have serious side effects and treating them or keeping them under control can be added. There are talks between pharmacy companies to introduce them as low-cost medicines in the price ranges of INR 50,000. So in the future, we can expect these drugs to hit the market with a reduced price tag.

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    Treatment After Liver Transplantation

    After liver transplantation reinfection of the graft leads to fast development of liver fibrosis, and consequently the risks of organ dysfunction and graft loss are significantly increased . Thus, antiviral treatment is essential to preserve liver function and ensure transplant survival . Severe post-transplantation cholestatic hepatitis and patients with moderate to severe fibrosis need urgent initiation of antiviral treatment to prevent graft loss . In the SOLAR-1 and -2 trials patients after liver transplantation show similar SVR rates compared to nontransplanted patients with the treatment of sofosbuvir/ledipasvir plus RBV . Comparable results were achieved by the combination of sofosbuvir/velpatasvir . These results are supported by data from several real-world studies confirming the efficacy and safety of DAA treatment in the post-transplantation setting. Potential DDI between DAA and immunosuppressive drugs require special attention, in particular when using protease inhibitors. However, the combination of glecaprevir/pibrentasvir is certainly a valuable pangenotypic alternative to sofosbuvir-containing regimens, in particular for patients with impaired kidney function after liver transplantation . During DAA treatment serum levels of immunosuppressant drugs have to be closely monitored.

    Cost Of Hepatitis C Medicines

    The newer direct-acting antiviral medicines for hepatitis C can be costly. Most government and private health insurance prescription drug plans provide some coverage for these medicines. Talk with your doctor about your health insurance coverage for hepatitis C medicines.

    Drug companies, nonprofit organizations, and some states offer programs that can help pay for hepatitis C medicines. If you need help paying for medicines, talk with your doctor. Learn more about financial help for hepatitis C medicines.

    Read Also: Hepatitis C Outside The Body

    How Do You Prevent Hepatitis C From Spreading

    • Avoid sharing the same needles: People who are intravenous drug users are at the risk of getting it because they may use the same needle many times. If the person snorts drugs cocaine this can also transmit the disease if the same straw is being used by another user.
    • Direct exposure to blood and blood products should not be done: If a person is a doctor or medical worker then they can get transmitted with infection if they come in direct contact of the blood. Therefore the equipment that is being used must be sterilized properly to prevent direct contact with blood and stop spreading it.
    • No sharing of personal care items: People must not share items of personal care with other people because they can be exposed to blood while shaving, or normal cuts thus it increases the danger of spreading it. If a person is already suffering from then they must take care that they do not spread it to other people by sharing the items.
    • Practising safe sex: It can be spread or transmitted through sexual activities or intercourse. The chance of getting hepatitis increases if you have HIV, multiple sex partners, or if you are engaged in rough sex. Therefore while having sex person must stay cautious and practice safe sex.

    Who Should Get Tested

    Module 7: Complementary and alternative interventions

    You should consider getting tested for hepatitis C if you’re worried you could have been infected or you fall into one of the groups at an increased risk of being infected.

    • Hepatitis C often has no symptoms, so you may still be infected if you feel healthy.
    • The following groups of people are at an increased risk of hepatitis C:
    • ex-drug users and current drug users, particularly users of injected drugs
    • people who received blood transfusions before September 1991
    • recipients of organ or tissue transplants before 1992
    • people who have lived or had medical treatment in an area where hepatitis C is common high risk areas include North Africa, the Middle East and Central and East Asia
    • babies and children whose mothers have hepatitis C
    • anyone accidentally exposed to the virus, such as health workers
    • people who have received a tattoo or piercing where equipment may not have been properly sterilised
    • sexual partners of people with hepatitis C

    If you continue to engage in high-risk activities, such as injecting drugs frequently, regular testing may be recommended. Your doctor will be able to advise you about this.

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    What Is Hepatitis C

    Hepatitis C is a liver infection that can lead to serious liver damage. Itâs caused by the hepatitis C virus. About 2.4 million people in the U.S. have the disease. But it causes few symptoms, so most of them don’t know. The virus spreads through an infected personâs blood or body fluids.

    There are many forms of the hepatitis C virus, or HCV. The most common in the U.S. is type 1. None is more serious than any other, but they respond differently to treatment.

    Stages Of Hepatitis C

    The hepatitis C virus affects people in different ways and has several stages:

    • Incubation period. This is the time between first exposure to the start of the disease. It can last anywhere from 14 to 80 days, but the average is 45
    • Acute hepatitis C. This is a short-term illness that lasts for the first 6 months after the virus enters your body. After that, some people who have it will get rid of, or clear, the virus on their own.
    • Chronic hepatitis C. For most people who get hepatitis C — up to 85% — the illness moves into a long-lasting stage . This is called a chronic hepatitis C infection and can lead to serious health problems like liver cancer or cirrhosis.
    • Cirrhosis. This disease leads to inflammation that, over time, replaces your healthy liver cells with scar tissue. It usually takes about 20 to 30 years for this to happen, though it can be faster if you drink alcohol or have HIV.
    • Liver cancer. Cirrhosis makes liver cancer more likely. Your doctor will make sure you get regular tests because there are usually no symptoms in the early stages.

    Learn more about the stages and progression of hepatitis C.

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    What Are The Side Effects Of The Hepatitis A Vaccine

    Hepatitis A

    The hepatitis A vaccine is made from inactive virus and is quite safe. In general, there are very few side effects. The most common potential side effect is soreness at or around the injection site. Other potential side effects include mild headache, loss of appetite among children, and feeling tired. These side effects usually last 1 or 2 days. However, like any medicine, the vaccine could cause serious problems, such as an allergic reaction, which may appear within a few minutes or hours after getting the shot. This occurs very rarely, but if you believe you are having a reaction to the vaccine you should call your provider right away. Some warning signs of a serious allergic reaction include the following:

    • High fever
    • Weakness or dizziness
    • A fast heart beat

    You will NOT get hepatitis A from the vaccine, and receiving the vaccine is much safer than getting the disease itself.

    What Are The Some Of The Most Common Side Effects Of Hepatitis C Medications

    How is our ability to treat and cure hepatitis C evolving?

    It depends on which drugs you take to treat hepatitis C.

    This once-a-day tablet could cure hepatitis in 12 to 16 weeks.

    You may have:

    • Depression
    • Low blood cell counts

    Talk to your doctor if youâve had an organ transplant, or if youâre pregnant, breastfeeding, or plan to get pregnant while taking it. It can cause miscarriages. Also tell your dentist or other doctor youâre on it before you have surgery or any other type of procedure.

    This comes as a tablet, capsule, or liquid. You take it with food twice a day, in the morning and evening, for 24 to 48 weeks or longer.

    You can expect to have:

    • Flu-like side effects
    • Gastrointestinal problems
    • Low blood cell counts
    • Low red blood cell count
    • Itching

    Donât take St. Johnâs wort while youâre on this medication. Also, youâll need to use two methods of birth control to prevent pregnancy in you or your partner while taking ribavirin and for 6 months after you stop.

    Youâll take it once a day for 12 weeks. Itâs OK for people who have cirrhosis and have already had some treatment.

    It could cause side effects like:

    • Headache
    • Fatigue

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    How Are Hepatitis B And C Treated

    Hepatitis B: Not all patients with chronic hepatitis B infection require treatment. At Yale Medicine, specialists decide on an individual basis whether a patient is an appropriate candidate for treatment. Generally, patients require treatment when their hepatitis B virus level is high, and when laboratory tests demonstrate significant inflammation or injury to the liver.

    There are currently seven approved drugs for hepatitis B, two of which are considered to be first-line treatments. These drugs are oral pills taken once daily, and while they’re very effective at suppressing the virus to very low or undetectable levels over the long term, they are not considered curative.

    Therefore, the goal of treatment is to control the virus long-term and decrease the risk of hepatitis B related complications such as cirrhosis and liver cancer.

    Hepatitis C: For the greater part of the last 20 years, treatment of hepatitis C required the use of a chemotherapy-like injection drug called interferon, which has been associated with serious side effects and a low cure rate. Fortunately, advances in hepatitis C treatments within the last three years now allow for the use of oral medications that are significant improvements in terms of safety and effectiveness.

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