Thursday, October 6, 2022

What Organ Does Hepatitis B Affect

Who Is Most Affected

Mayo Clinic Minute: ABCs of hepatitis

In the United States, rates of new HBV infections are highest among adults aged 40-49 years, reflecting low hepatitis B vaccination coverage among adults at risk. The most common risk factor among people with new HBV infections is injecting drugs, related to the opioid crisis.

The highest rates of chronic hepatitis B infection in the United States occur among foreign-born individuals, especially people born in Asia, the Pacific Islands, and Africa. Approximately 70% of cases in the United States are among people who were born outside of the United States. CDC developed this map of the geographic distribution of hepatitis B around the world – PDF. Other groups who have higher rates of chronic HBV infection include people who inject drugs and men who have sex with men.

Immunisation For Hepatitis B

Immunisation is the best protection against hepatitis B infection. A course of vaccination is recommended for all babies and people in high-risk groups.

Immunisation can be with a vaccine against hepatitis B alone or with a combination vaccine. To be immunised, contact your doctor or local council.

Protection against hepatitis B is available free of charge under the National Immunisation Program Schedule. In Victoria, immunisation against hepatitis B is free for:

  • Babies at birth immunisation against hepatitis B alone as soon as possible after birth.
  • Babies at 2, 4 and 6 months combination immunisation in the form of a diphtheria, tetanus, whooping cough, hepatitis B, polio and Haemophilus influenzae type b vaccine .
  • Premature babies at 12 months premature babies born under 32 weeks gestation or under 2,000g birth weight receive a single booster dose.
  • Children up to and including 9 years of age.
  • People aged less than 20 years having a catch-up immunisation.
  • Refugees and humanitarian entrants aged 20 years and above.

In Victoria, free hepatitis B vaccine is provided for people who are at increased risk of infection, including:

Immunisation is also recommended, but not necessarily free, for people who are at increased risk of infection, including:

Who Are Hepatitis B Carriers

Hepatitis B carriers are people who have the hepatitis B virus in their blood, even though they dont feel sick. Between 6% and 10% of those people whove been infected with the virus will become carriers and can infect others without knowing it. There are over 250 million people in the world who are carriers of HBV, with about 10% to 15% of the total located in India. Children are at the highest risk of becoming carriers. About 9 in 10 babies infected at birth become HBV carriers, and about half of children who are infected between birth and age 5 carry the virus. A blood test can tell you if you are a hepatitis B carrier.

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What Is Involved In A Liver Transplant

A liver transplant is considered necessary when the liver is damaged and cannot function or in some cases of liver cancer. Your liver is very important. It is responsible for many functions related to making sure that your body stays healthy and is able to digest foods.

You may be eligible for a transplant if you have chronic hepatitis B infection or some of the diseases that may result from it, including liver cancer and cirrhosis. You will have to complete testing and be evaluated before being approved for a transplant. It is likely that you will be placed on a waiting list while an appropriate organ is found.

Donated livers come from two types of donors: living and deceased. Because the liver can regenerate, it is possible to use part of a liver for transplant. The remaining sections in both the donor and the receiver will grow into livers of adequate size.

People who get liver transplants must take anti-rejection drugs for the rest of their lives. These drugs make you more susceptible to infection. However, liver transplants have become more successful over time and continue to improve.

How Are Hepatitis B And C Diagnosed

Why Do I Feel Worse After Hepatitis C Treatment?

Hepatitis B is diagnosed by a series of blood tests. The test may show an ongoing infection or antibodies that indicate that the patient is protected against hepatitis B. In patients who have a positive screening test that suggests the possibility of ongoing infection, further testing is done to determine the levels of the virus in the bloodstream.

Hepatitis C is diagnosed via a blood test called a Hepatitis C Antibody Test. A positive result means that hepatitis C antibodies are present in the blood. But a positive antibody test doesnt necessarily mean a person has hepatitis C. A further blood test is needed to confirm the diagnosis. This second blood test quantifies the amount of the virus or the viral load in the liver and the bloodstream.

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From Person To Person

Blood and other bodily fluids, such as semen and vaginal secretions, contain the virus in infected people. The main ways in which people in the UK become infected include the following:

  • Having unprotected sex with an infected person. Even having oral sex can transmit hepatitis B.
  • From infected blood. You only need a tiny amount of infected blood to come into contact with a cut or wound on your body to allow the virus to enter your bloodstream, multiply and cause infection. For example:
  • Sharing needles and/or any injecting equipment to inject drugs. Even a tiny amount of blood left on a needle from an infected person is enough to cause spread to others.
  • Some people who had a blood transfusion or another blood product several years ago were infected with hepatitis B. Now, all blood donated in the UK is checked for the hepatitis B virus . So, the risk of getting hepatitis B from a blood transfusion in the UK is now very small.
  • From ‘needlestick’ accidents where the needle was used on an infected person.
  • There is a small risk of contracting the virus from sharing toothbrushes, razors and other such items which may be contaminated with blood. The virus can actually live outside the body for more than one week.
  • From using equipment which is not sterile for dental work, medical procedures, tattooing, body piercing, etc.
  • A bite from an infected person, or if their blood spills on to a wound on your skin, or on to your eyes or into your mouth.

Is Hepatitis Testing Recommended For People With Hiv

Yes. Everyone living with HIV should be tested for HBV and HCV when they are first diagnosed with HIV and begin treatment. People living with HIV who have ongoing risk factors for getting hepatitis B or hepatitis C should be tested annually.

In addition, new HCV screening recommendations from the Centers for Disease Control and Prevention call for:

  • One-time screening for all adults 18 years and older
  • Screening of all pregnant women during every pregnancy
  • Testing for all persons with risk factors, with testing continued periodic testing those with ongoing risk.

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Causes Of Hepatitis B

Hepatitis B is spread through contact with blood that contains the hepatitis B virus. If infected blood or body fluids enter another persons bloodstream, that person may become infected.

The time from exposure to the hepatitis B virus to the appearance of the illness is 45 to 180 days.

Risky activities that can cause infection include:

  • Sharing unsterile or unclean equipment for injecting drugs.
  • Piercing the skin with equipment that is not properly cleaned, disinfected and sterilised.
  • Sharing razor blades or toothbrushes.
  • Coming into contact with infected blood through open cuts or the mucous membranes of another person.
  • Having unprotected sex , especially if there is blood present.

Mothers who have hepatitis B can pass the virus to their babies or children at the time of birth or after birth. If the newborn baby is quickly immunised with 2 vaccines, they can be protected from getting hepatitis B.

All blood and blood products produced for medical purposes in Australia are carefully screened for hepatitis B and other blood-borne viruses. The risk of getting infected with hepatitis B from a blood transfusion is extremely low .

What Happens In Co

Hepatitis B Can Cause Liver Damage, Cancer

The human immunodeficiency virus and hepatitis B virus are transmitted in similar ways, and it is not uncommon for an individual to have both infections. People with HIV who acquire hepatitis B are more likely to become chronically infected with hepatitis B than people who do not have HIV. The reason for this is thought to be that HIV suppresses the immune system and impairs the ability of the body to eliminate the hepatitis B virus. Some nucleoside/nucleotide analogues are used to treat both HIV and hepatitis B, although dosages may vary in the two different infections. Stopping one of these agents when the HIV regimen is adjusted may cause hepatitis to flare.

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How To Prevent Hepatitis B

Hepatitis B is a liver infection caused by a virus . It can be serious and theres no cure, but the good news is its easy to prevent. You can protect yourself by getting the hepatitis B vaccine and having safer sex. If you have oral, anal, and vaginal sex, use condoms and dental dams to help stop the spread of hepatitis B and other STDs.

Who Should Be Vaccinated For Hepatitis B

All newborns should be vaccinated. Also, people who are under 18 who were not vaccinated at birth should also get the vaccine. Other groups who should be sure to be vaccinated are those in certain high-risk categories, such as:

  • People who have more than one sexual partner.
  • Men who have sex with men.
  • Adults with diabetes.
  • Sexual partners of infected people and people who share households with infected individuals.
  • People who are exposed to blood and other bodily fluids, including healthcare and public safety professionals, and people who work in jails and other places taking care of people who cant take care of themselves.

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What Is The Treatment For Hepatitis B

Prevention is recommended by receiving a vaccine for HBV.

Receiving an injection of the hepatitis B immune globulin within 12 hours of coming in contact with the virus may help prevent the development of the disease.

At present, there is no specific treatment for patients with acute hepatitis B. Acute infection is usually short and will often resolve on its own. Your health care provider may recommend rest, and adequate nutrition and fluids to help your body fight the infection. Hospitalization may be required for patients who suffer from severe vomiting and who are unable to maintain adequate nutritional levels. It may also be required to prevent the development of complications.

While chronic infection cannot be cured, there are two standard treatments in Canada that may control the virus and prevent further damage to the liver.

  • Antiviral medications can fight the virus and slow damage to the liver.
  • Interferon which may be given for short periods and if effective, results in suppression of the virus.

How Is Hepatitis B Diagnosed And Assessed

Is it a hepatitis C rash?

A simple blood test can detect if you are infected with the hepatitis B germ . This test detects a protein on the surface of the virus called hepatitis B surface antigen . If you are found to be infected then other tests may be advised to check on the severity of infection, liver inflammation and damage to the liver.

For example:

  • A blood test can detect various parts of the virus. This can assess how active the virus is .
  • Blood tests called liver function tests. These measure the activity of chemicals and other substances made in the liver. This gives a general guide as to whether the liver is inflamed, and how well it is working.
  • A small sample of the liver may be taken to look at under the microscope. This can show the extent of any inflammation and scarring of the liver .
  • A blood test can also be performed to show if you have immunity to hepatitis B.
  • Other tests may be done if cirrhosis or other complications develop.
  • There are other specialised blood tests being developed which assess the development and severity of cirrhosis.

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How Long Does It Last

Hepatitis A can last from a few weeks to several months.

Hepatitis B can range from a mild illness, lasting a few weeks, to a serious, life-long condition. More than 90% of unimmunized infants who get infected develop a chronic infection, but 6%10% of older children and adults who get infected develop chronic hepatitis B.

Hepatitis C can range from a mild illness, lasting a few weeks, to a serious, life-long infection. Most people who get infected with the hepatitis C virus develop chronic hepatitis C.

Is There A Cure For Chronic Hepatitis B

Currently, there is no complete cure for hepatitis B. But when managed properly, those living with the virus can expect to live a normal life. Maintaining a healthy diet and avoiding alcoholic beverages and tobacco products are crucial components in managing the disease.

You should also visit a doctor familiar with hepatitis B at least annuallythough twice a year might be best to monitor your liver through blood tests and medical imaging. As with most diseases, detecting it early leads to a better outcome. If youre exposed to the virus, you should get an antibody injection within 12 hours of exposure.

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What Treatments Are Available For Chronic Hepatitis B If Medications Dont Work

If you have advanced hepatitis B, you might also become a candidate for a liver transplant. This path does not always result in a cure because the virus continues in your bloodstream after a transplant. To prevent being infected again after your transplant, you may be prescribed hepatitis B immunoglobulin with an antiviral agent.

What Are The Symptoms Of Hepatitis A

Hepatitis B and Liver Disease in Asians

Some people have symptoms 2 to 7 weeks after they come in contact with the virus.3 People with hepatitis A typically get better without treatment after a few weeks. In some cases, symptoms can last up to 6 months. These symptoms may include

Some people infected with hepatitis A have no symptoms, including many children younger than age 6.3 Older children and adults are more likely to have symptoms.

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Liver Anatomy And Function

Main Function of the Liver

The liver is an essential organ that has many functions in the body. The liver plays an important role in detoxifying the body by converting ammonia, a byproduct of metabolism in the body, into urea that is excreted in the urine by the kidneys. The liver also breaks down medications and drugs, including alcohol, and is responsible for breaking down insulin and other hormones in the body. The liver also stores vitamins and chemicals that the body requires as building blocks.

Many different disease processes can occur in the liver, including infections such as hepatitis, cirrhosis , cancers, and damage by medications or toxins.

Symptoms of liver disease can include:

  • Jaundice

Where Is The Hepatitis B Virus Found And How Is It Transmitted

Blood is the major source of the hepatitis B virus in the workplace. It can also be found in other tissues and body fluids, but in much lower concentrations. The risk of transmission varies according to the specific source. The virus can survive outside the body for at least 7 days and still be able to cause infection.

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Hiv And Hepatitis B And Hepatitis C Coinfection

Hepatitis B and hepatitis C are liver infections caused by a virus. Because these infections can be spread in the same ways as HIV, people with HIV in the United States are often also affected by chronic viral hepatitis.

Viral hepatitis progresses faster and causes more liver-related health problems among people with HIV than among those who do not have HIV. Liver disease, much of which is related to HBV or HCV, is a major cause of non-AIDS-related deaths among people with HIV.

Given the risks of hepatitis B or hepatitis C coinfection to the health of people living with HIV, it is important to understand these risks, take steps to prevent infection, know your status, and, if necessary, get medical care from someone who is experienced in treating people who are coinfected with HIV and HBV, or HIV and HCV.

Treatment For Chronic Hbv Infection

So, How

For chronic HBV infection, antiviral medications are available.

This is not a cure for chronic HBV. However, it can stop the virus from replicating and prevent its progression into advanced liver disease.

A person with a chronic HBV infection can develop cirrhosis or liver cancer rapidly and without warning. If a person does not have access to adequate treatment or facilities, liver cancer can be fatal within months of diagnosis.

People with a chronic HBV infection require ongoing medical evaluation and an ultrasound of the liver

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What Are Clinical Trials For Hepatitis B

Clinical trialsand other types of clinical studiesare part of medical research and involve people like you. When you volunteer to take part in a clinical study, you help doctors and researchers learn more about disease and improve health care for people in the future.

Researchers are studying many aspects of hepatitis B, such as

  • progression of hepatitis B and long-term outcomes
  • new treatments for hepatitis B
  • prevention of reactivated or worsening hepatitis B in people receiving cancer treatment

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