Wednesday, September 21, 2022

Medicine To Cure Hepatitis C

Is Harvoni A Cure For Hepatitis C

New treatment to cure Hepatitis C

The word âcureâ has a very specific meaning for hepatitis C. It means there is no virus in your blood 12 weeks after your treatment is over. The cure rate for Harvoni is 94% to 99% when you donât have other serious illnesses.

Harvoni might not work as well if:

  • You have advanced liver disease.
  • Your liver has some scarring .
  • Youâve had treatment for hep C before and it didn’t work.
  • You donât take your pills as prescribed.

In many cases, your doctor can adjust your dose and length of your treatment if Harvoni isn’t working well for you. In some treatment plans, Harvoni may team with another drug called ribavirin .

Who Is More Likely To Get Hepatitis C

People more likely to get hepatitis C are those who

  • have injected drugs
  • had a blood transfusion or organ transplant before July 1992
  • have hemophilia and received clotting factor before 1987
  • have been on kidney dialysis
  • have been in contact with blood or infected needles at work
  • have had tattoos or body piercings
  • have worked or lived in a prison
  • were born to a mother with hepatitis C
  • are infected with HIV
  • have had more than one sex partner in the last 6 months or have a history of sexually transmitted disease
  • are men who have or had sex with men

In the United States, injecting drugs is the most common way that people get hepatitis C.13

Treatment For Acute And Chronic Hepatitis C Infection

Some people are diagnosed with hepatitis C when the infection is in the acute phase . About one in four people will clear the hepatitis C virus from their body on their own within six months. When a person is diagnosed with hepatitis C in the acute phase, a healthcare provider might recommend waiting to see if their body clears the virus on its own.

Current treatment guidelines in Canada focus on treatment for chronic hepatitis C infection . The treatment guidelines recommend that treatment of acute hepatitis C infection be assessed on an individualized basis. In many cases, a person has to progress to chronic hepatitis C infection before they can receive public or private drug coverage for hepatitis C treatments.

Also Check: Hepatitis C Symptoms Mayo Clinic

Pregnancy And Hepatitis C

The new hepatitis C medicines have not been tested in pregnancy.

You should not become pregnant while taking treatment as it could be harmful to unborn babies.

If you’re pregnant, you must delay treatment until after your baby is born.

Speak to your doctor before starting hepatitis C treatment if you’re planning to become pregnant in the near future.

You’ll need to wait several weeks after treatment has ended before trying to get pregnant.

Women taking ribavirin should use contraception during treatment and for another 4 months after the end of treatment.

Men taking ribavirin should use a condom during treatment and for another 7 months after the end of treatment. This is because semen can contain ribavirin.

If you become pregnant during treatment, speak to your doctor as soon as possible to discuss your treatment options.

What Can People Do To Help The Medications Work Best

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  • Take the medications every day
  • Stay in touch with pharmacy to be sure that all refills are ready on time
  • Take the medications exactly as prescribed
  • Do not skip doses
  • Get all blood tests done on time
  • Go to all visits with providers as recommended
  • Tell the provider about all other medications that are being taken – including over-the-counter medicines, vitamins, herbs, and supplements
  • Complete the entire course of medication

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We Have A Cure For Hepatitis C Why Are Rates So High

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We have had the ability to cure many people of hepatitis C — a common viral infection of the liver — since 2011. These new drugs are effective at curing most strains of the virus and have far fewer side effects than earlier generations of treatment. Despite these major scientific advances, however, hepatitis C rates remain high, particularly among those who are also living with HIV, as well as among people in prison and people using drugs, particularly drugs taken by injection.

Our lack of progress toward eliminating hepatitis lies in a poor screening and surveillance system, the continuing opioid epidemic, and the high cost of the cures — which has led many insurers, most notably Medicaid, to limit treatment to those who are already suffering some of the long-term consequences of this infection.

What Will My Doctor Need To Know To Treat Me

If you want to be assessed for treatment, you need to make an appointment with a doctor. They will be mostly interested in the condition of your liver. Your doctor will organise, if possible, for you to have a Fibroscan examination. If Fibroscan is not available, your doctor will probably use an APRI test. This is an online calculator that estimates the health of your liver. It involves a blood test called a liver function test.

Dont forget, its very important to get a PCR test 12 weeks after finishing treatment this will mean the doctor can make sure you are cured.

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Tests For The Hepatitis C Virus

If your doctor thinks that you may have hepatitis C, he or she may order:

    • A hepatitis C virus test. This is a blood test that looks for antibodies against the hepatitis C virus. It shows whether you have been exposed to the virus.
    • A blood test that looks for the genetic material of the hepatitis C virus. This test shows whether you are infected with the virus now.
    • A blood test to find out the kind of hepatitis C virus you have. Knowing your genotype will help you and your doctor decide if and how you should be treated.

What Are The Symptoms

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Most people have no symptoms when they are first infected with the hepatitis C virus. If you do develop symptoms, they may include:

    • Feeling very tired.
    • Sore muscles.
    • Dark urine.
    • Yellowish eyes and skin . Jaundice usually appears only after other symptoms have started to go away.

Most people go on to develop chronic hepatitis C but still don’t have symptoms. This makes it common for people to have hepatitis C for 15 years or longer before it is diagnosed.

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  • Recent advances in antiviral treatment have led to the development of new highly effective drugs for the treatment of all types of hepatitis C.
  • The new hepatitis C treatments are sofosbuvir with ledipasvir sofosbuvir daclatasvir and ribavirin .
  • These new treatments are now available on the Pharmaceuticals Benefits Scheme.

Treatment If The Condition Gets Worse

Severe liver damage caused by chronic hepatitis C usually takes 20 or more years to develop.

If your hepatitis C continues to get worse, it can cause your liver to stop working, a condition called end-stage liver failure. In this case, a liver transplant may be the only way to extend your life. But if you are drinking alcohol, are sharing needles to inject drugs, or have severe depression or certain other mental illnesses, liver transplant may not be an option.

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What Does Treatment With The New Drugs Involve

The drugs are easy to take and are taken orally.

Treatment time is usually 12 weeks. However this may range between 8 and 24 weeks for a complete course of treatment, depending on the patients genotype, whether the patient has cirrhosis, treatment history and which of the drug combinations the prescriber chooses to use.

How Much Will It Cost Patients To Access The New Drugs

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The Pharmaceutical Benefits Scheme listing means that hepatitis C patients will only pay the normal co-payment for the new drugs. The co-payment is currently worth $6.20 for patients with concessional healthcare cards and $38.30 for general patients without concessional healthcare cards, per drug, per month. For some patients needing three drugs, for example, the co-payment will therefore be $114.90 per month, or $18.60 per month concession.

More information on co-payment charges can be found on the Commonwealth Department of Healths website

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Ombitasvir Paritaprevir And Ritonavir

Doctors may prescribe this combination of drugs to treat hepatitis C genotype 4. They may also prescribe ribavirin.

  • Facts about Technivie include:
  • Treatment time is 12 weeks.
  • Dosage is a fixed-dose combination of 12.5 mg ombitasvir, 75 mg paritaprevir, and 50 mg ritonavir taken once daily.
  • Common side effects include weakness, tiredness, nausea, and sleep problems.

Is There A Way To Prevent Hepatitis C

Although currently theres no vaccine to protect people from contracting hepatitis C, there are vaccines for other hepatitis viruses, including hepatitis A and hepatitis B.

If you receive a hepatitis C diagnosis, your healthcare provider may advise you to get vaccinated against hepatitis A and B.

The vaccinations are recommended because these hepatitis viruses can lead to additional health and liver complications, especially in those with preexisting liver disease.

Since you cant prevent hepatitis C through a vaccine, the best prevention is to avoid exposure. Hepatitis C is a bloodborne pathogen, so you can limit your chances of exposure through these healthy lifestyle practices:

  • Avoid sharing needles, razor blades, or nail clippers.
  • Use proper safety precautions if youll be exposed to bodily fluids, such as when performing first aid.
  • Hepatitis C isnt usually transmitted through sexual contact, but its possible. Limit your exposure by practicing sex with a condom or other barrier method. Its also important to openly communicate with sexual partners and to get tested if you suspect youve been exposed to the hepatitis C virus.

Because hepatitis C is transmitted through blood, its possible to contract it through a blood transfusion.

However, since the early 1990s, blood product screening tests have been standard protocol for minimizing the risk of this type of transmission.

Subsequent testing is based on risk. Talk to your doctor about your needs.

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What If I Use Street Drugs

You can get treated and cured for hepatitis C while still using drugs. Treatments work just as well to cure hepatitis C if you are using drugs. You deserve respectful care by doctors, nurses and other health workers. Talk about your situation with a health worker you trust.

Some hepatitis C medicines can change the effects of the drugs you use, which can contribute to an overdose. The first time you use drugs after you start treatment, start slowly, use with someone you trust and keep Naloxone nearby.

Ombitasvir Paritaprevir And Ritonavir Tablets Co

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This is a relatively new group of medicines that treat genotype 1 hepatitis.

Facts about the drug pack include:

  • Treatment time is 12 or 24 weeks.
  • Dosage is a pack of tablets containing 12.5 mg of ombitasvir, 75 mg of paritaprevir, and 50 mg ritonavir, taken once daily in the morning, and one 250 mg tablet of dasabuvir taken twice daily with a meal.
  • Common side effects of this group of drugs include nausea, itching, and trouble sleeping. If the person also takes ribavirin, side effects include tiredness, nausea, fatigue, and skin reactions.

The following medications may be effective for genotype 2:

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Acytokines Alter Mental Processes And Behavior

There is striking evidence that cytokines administered in large doses as part of cancer treatment and hepatitis-C treatment can cause disturbances of mental function that resemble psychiatric disorders. Cytokines such as IFN- and IL-2 have been found, depending on dosage, to cause major mental status changes in as many as two-thirds of patients receiving the treatments. The changes observed include delirium , disorientation, irritability, delusions, agitation, fatigue, anorexia, malaise, and depression. Many of these changes are also seen in response to infection, thereby supporting the role of immune activity in behavioral disturbance and psychopathological conditions.

Studies in healthy humans using immune-activating substances such as endotoxin derived from Gram-negative bacterial membrane or vaccination with typhoid antigen have shown effects on mood and cognition. With respect to memory, the findings have been mixed with some studies showing decrements in memory function while others have found no effect. The effect on mood has tended to be more consistent and in the direction of increasing confusion, fatigue, and tension. Moreover, neuroimaging studies have shown that individuals injected with immune-activating substances show increased activity in limbic regions of the brain in response to pictures of faces expressing specific emotions. A finding suggesting immune modulation of emotional responses.

Interferons And Pegylated Interferons

The two most frequently used recombinant interferon preparations in clinical trials have been IFN alfa-2b and IFN alfa-2a , which differ from each other by only a single amino acid residue. IFN alfacon-1 , or consensus IFN, is a genetically engineered compound synthesized by combining the most common amino acid sequences from all 12 naturally occurring IFNs. Roferon-A was discontinued from the market in 2007 and Infergen was discontinued from the market in 2013.

The addition of propylene glycol molecules to IFN has led to the development of long-lasting IFNs that have better sustained absorption, a slower rate of clearance, and a longer half-life than unmodified IFN, which permits more convenient once-weekly dosing. The FDA has approved PEG-IFNs for the treatment of chronic hepatitis C.

Two PEG-IFN preparations are available for the treatment of chronic hepatitis C. PEG-IFN alfa-2b consists of IFN alfa-2b attached to a single 12-kd PEG chain it is excreted by the kidneys. PEG-IFN alfa-2a consists of IFN alfa-2a attached to a 40-kd branched PEG molecule it is metabolized predominantly by the liver.

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Can You Drink Alcohol If You Have Hepatitis C

Hepatitis is inflammation of the liver. Hepatitis C viral infection causes this inflammation. There are several risk factors for contracting HCV infection due to the hepatitis C virus. One serious risk factor is drinking alcohol with HCV infection. The combination of HCV and alcohol can cause complications, and may result in more severe and serious liver injury including chronic cirrhosis . It also increases your chances of developing liver cancer having an alcohol induced increase in viral replication and rapid mutation of the hep C virus,which creates complications like:

  • Greater viral capacity

Hepatitis refers to any cause of liver inflammation, with or without scarring of the liver . It is contagious, and is spread from person-to-person by blood-to-blood contact. Other viral causes of hepatitis include hepatitis A, B, C, and E. Other types of noninfectious causes of hepatitis include:

How are hepatitis A, B, and E spread?

  • Transmission of hepatitis A and E: These forms of the virus are acquired from improper hygiene during food or drink preparation by someone who’s infected.
  • Transmission of hepatitis B: This form is spread by blood-to-blood or sexual contact.

What About Patients With Hepatitis C Who Also Have Hepatitis B

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Hepatitis B virus can flare in patients who are co-infected with hepatitis B and hepatitis C and are taking medication for hepatitis C. This has been reported as a potential risk for patients who are taking hepatitis C treatment and have underlying hepatitis B as well. The flare usually occurs within a few weeks after the patient starts taking medication for hepatitis C. Therefore, patients who have both hepatitis B and hepatitis C should be seen by a hepatitis expertbeforestarting treatment of the hepatitis C they may need to start taking hepatitis B treatment to avoid a hepatitis B flare.

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How Does Harvoni Work

Hepatitis means inflamed liver. After 6 months, itâs called âchronicâ and in some cases may eventually lead to heavy scarring of the liver . The hepatitis C virus spreads most commonly through needles shared by drug users, but sexual contact can also pass it on.

Harvoni is a combination of two drugs. Each one blocks a protein that the hep c virus needs in order to grow:

  • Ledipasvir blocks a protein called NS5A.
  • Sofosbuvir blocks an enzyme called NS5B RNA-dependent RNA polymerase.

Can A Transplant Cure Hepatitis C

If you develop chronic hepatitis C and it leads to liver cancer or liver failure, you may need a liver transplant. Hepatitis C is one of the most common reasons for a liver transplant.

A liver transplant removes a damaged liver and replaces it with a healthy one. However, theres a high likelihood that the hepatitis C virus will be transmitted to the new liver in time.

The virus lives in your bloodstream, not just your liver. Removing your liver wont cure the disease.

If you have active hepatitis C, continued damage to your new liver is very likely, especially if hepatitis C remains untreated.

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How You Take It

Harvoni is a pill you take once a day for 2 to 6 months. How long you’ll take it depends on how much of the virus is in your blood , as well as:

  • Your health history
  • Which hep C treatments you’ve taken
  • Other health issues you have

Talk to your doctor if you have any questions about how to take your medications.

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