Thursday, May 30, 2024

Hepato Support For Dogs Side Effects

A Good Diet Includes Dog Supplements For Liver Disease

ANTIBIOTICS FOR CATS & DOGS: When to use them & how to support our pets to help prevent side effects

There is no specific diet that fits for all dogs, but there are a few Dog Supplements For Liver Disease that are recommended. The goal of any dietary treatments is four-part:

  • To provide good nutrition for energy
  • To promote liver regeneration and keep minimum stress on the liver
  • To prevent toxins from moving to the brain
  • To inhibit further damage from buildup of substances such as copper
  • When it comes to good nutrition for energy, protein is typically what your pet needs. However, for dogs with liver disease, the amount of protein they should take in can vary. Some stages will require more protein, some stages will recommend less. When protein is limited, many vets will suggest dairy, soy, and eggs rather than meat sources.

    Side Effects From Common Flea And Tick Products

    Isoxazoline based products used for prevention and treatment of fleas, ticks, and mites are gaining popularity. Many traditional veterinarians are strongly recommending the use of the isoxazoline class of products. Unfortunately, as the number of animals being given these products has risen, so has the number of pet owners reporting neurological and other adverse reactions.

    What side effects are possible when using these drugs?

    Neurological side effects or adverse reactions can range from barely noticeable to severe. Adverse reactions to these compounds appear to affect animals randomly, although those with certain chronic diseases, the young and elderly, and animals that are immune-compromised or have the genetic mutation of the MDR1 gene seem to be at higher risk. A survey of pet owners showed that adverse reactions are common.

    Some adverse reactions that my clients have seen include:

    • Aggression
    • Drooling

    What should I do if I believe my pet is having an adverse reaction?


    Some pet parents have continued these supplements for longer periods of time with no adverse effects if the pet is still experiencing symptoms. If your pet is experiencing seizures, I have additional suggestions.

    Report the incident to the FDA and the manufacturer!

    Disorders Of The Liver And Gallbladder In Dogs

    , BS, DVM, DACVIM, Department of Clinical Sciences, College of Veterinary Medicine, Cornell University

    The liver is an organ that performs numerous functions. It has a large storage capacity and functional reserve and is capable of regenerating. These properties provide some protection against permanent damage. However, the liver is also susceptible to injury because of its role in metabolizing, detoxifying, and storing various toxic compounds.

    Signs that a dog has liver disease can vary and include loss of appetite, vomiting, stomach ulceration, diarrhea, seizures or other neurologic problems, fever, blood clotting problems, jaundice , fluid collection in the abdomen, excessive urination and thirst, changes in liver size, and weight loss. Gastrointestinal bleeding can be seen in animals with liver disease due to ulcers or problems with blood clotting. The veterinarians understanding of the potential causes of each of these signs helps him or her to diagnose illness and provide appropriate treatment.

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    Diseases Of The Gallbladder And Bile Duct

    The liver secretes bile, a substance that assists with digestion and absorption of fats and with elimination of certain waste products from the body. Bile is stored in the gallbladder and is released into the small intestine through the bile duct.

    Jaundice is often the main sign of diseases of the gallbladder and bile duct. An exception is cancer of the gallbladder, which may not cause jaundice.

    Gallbladder agenesis is the lack of a gallbladder from birth. Unless the bile ducts within the liver are also missing, the lack of a gallbladder doesn’t cause any problems.

    Biliary atresia is the lack of development of bile ducts within the liver and is uncommon. Affected dogs are jaundiced and unthrifty at a young age. The outlook is poor.

    Cystic mucosal hyperplasia of the gallbladder is also known as cystic mucinous hypertrophy, cystic mucinous hyperplasia, and mucinous cholecystitis. It is the development and growth of cysts filled with mucusin the gallbladder. It may be caused by treatment with steroid hormones, such as female reproductive hormones. An early stage of the disorder may be a condition known as gallblader dysmotility.

    Functions Of The Liver

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    • Metabolizes fats, carbohydrates, and proteins

    • Metabolizes drugs

    • Stores, metabolizes, and activates vitamins

    • Stores minerals, glycogen, and triglycerides

    • Manufactures proteins needed for various body functions, such as blood clotting

    • Produces bile acids needed for digestion

    • Detoxifies harmful products manufactured within the body or consumed by the animal

    • Influences immune responses

    • Helps develop blood cells

    Prescribed supplements may include B vitamins, vitamin K, and vitamin E. Low potassium levels and decreased levels of B vitamins are common complications with liver disease, and supplementation is often recommended. Vitamin C does not appear to become depleted in dogs with liver disease, and supplementation is not recommended in dogs with copper storage liver disease. Injections of vitamin K are sometimes given to dogs with bleeding tendencies. Follow your veterinarian’s recommendations on vitamin supplementation because overdoses of some vitamins can be harmful.

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    Silymarin Has Been Found To Possess The Following Attributes That Are Useful In Veterinary Medicine:

    1. Antioxidant scavenges ROS and protects against glutathione depletion2. Inhibits hepatocyte membrane lipid peroxidation 3. Antifibrotic5. Increases hepatic protein synthesis6. Increases rate of hepatocyte regeneration7. Choleretic thins the bile, stimulates contraction of gall bladder8. Protects DNA by reducing lipoxygenase, hydrogen peroxide, and superoxide radicals9. Suppresses transcription factor -kappaB10. Chelates iron which helps to spare glutathione with iron overload11. Stabilizes mast cells 12. Slows calcium metabolism 13. Decreases activity of promoters of cancer growth.

    Hepato Support, contains silymarin complexed with hepatotrophic nutraceuticals to facilitate normalization of liver function. The addition of these nutrients improves the efficacy of the silymarin alone by supporting the metabolic, antioxidant, and detoxification functions of the liver.

    This study can be read in its entirety by clicking here.

    Purchase Hepato Support from Rx Vitamins.

    NB: It is important for my clients to understand that nutraceutical support of this type only addresses the physiologic piece of the liver diease puzzle. Hepato Support and similar supplements are wonderful for supporting the body while it heals naturally. The healing process itself is best addressed using gentle energetic homeopathic stimulation.Dr. Jeff

    Symptoms Of Hepatic Failure In Dogs

    There are a variety of symptoms of hepatic failure that can be seen in your dog. The first signs that are typically seen in hepatic failure are:

    • Vomiting

    More severe symptoms may constitute an emergency requiring immediate attention. These include:

    • Excessive thirst
    • Seizures


    Hepatic failure may happen suddenly or develop slowly. Acute hepatic failure can occur in conjunction with any condition that affects the liver for example, hepatic failure can be caused by poisoning if the toxins taken in by your dog are more than what his liver is able to handle. Hepatic failure can also occur as a result of long term, chronic liver disease where the disease progresses slowly, but over time your dog will develop symptoms of hepatic failure.

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    Where Do I Obtain Milk Thistle And Do I Need A Prescription

    Milk thistle is available as an extract or tincture. Pet owners are cautioned against buying supplements without knowledge of the manufacturer, as supplements are not highly regulated and some supplements may not contain the labeled amount of ingredients. Your veterinarian may have preferred brands of supplements that he or she will recommend. A prescription is not needed for milk thistle.

    Contributors: Cheryl Yuill, DVM, MSc, CVH

    Zesty Paws Liver & Kidney Support Supplement For Dogs

    15 Side Effects of Antibiotics in Dogs (And What To Do ASAP!)
    • Featuring silactive at 110 mg per chew, silactive is a standardized form of milk thistle, an herbal extract with properties that support kidney health and liver’s natural detoxifying process..
    • Premium curcumin & bioperine each bite contains qmin+ curcumin to support liver function, while bioperine is a premium black pepper extract that increases curcumin absorption..
    • Healthy liver & kidneys = happy life! zesty paws liver support bites are grain-free chewable supplements with holistic natural ingredients that support canine liver and kidney health..
    • For healthy liver function these pet treats also include cranberry, blueberry, choline bitartrate, and dandelion root powder to provide additional support for your dog’s liver activity..
    • Bad liver? here’s what to look for – if you notice weight changes, fatigue, bloating, vomiting, loose stool, or excessive thirst, your pup’s liver might need some tlc.

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    My Benji And I Need Advice

    We had a lot of blood work done. Much was good but some was not. Cholesterol is somewhat of a problem but the liver is the big concern. It has been somewhat elevated for sometime. The vet has prescribed Hepato support capsules. He has been taking 2 a day for a long time. Also he takes potassium citrate for urine crystals – had to have surgery a couple of years ago for a bladder stone. He is also on thyroid meds.His Liver ALT is now 171. In March it was 123. 100 is normal

    His other liver test should be between 23 and 212 and in March it was 840. Now it is 1389

    We are presently feeding him Hill’s prescription U/D food – 1 1/4 cups a day and 8 large kibbles of Hills prescription T/D food, He also gets glucosomine and aquafresh in his water, thyroid meds and prescription tooth paste. The thyroid test was fine and so were the other tests.He has been drinking much more water than usual as well.

    The vet is away right now but the staff is asking Hills what other diet that he could have and still be able to take the Pottassium citrate. He will let us know in a few days.

    I’ve read on the internet that this could be caused by a trauma. He has not been hit by a car but he has fallen several times recently while going upstairs and landed very, very hard on his abdomen area.

    I also notice that eating wild mushrooms can cause a problem. We did have quite a few in the yard awhile ago but I tried to get rid of them all. I doubt if he got any but can’t be sure.

    I Have Been Told That Corticosteroids Can Cause Cushing’s Disease Why Is This

    An excessive level of corticosteroids may cause Cushing’s disease. When a dog is on long-term, high doses of glucocorticoids, there is an increased risk that a condition called iatrogenic Cushing’s disease will develop. The clinical signs of Cushing’s disease include increased thirst and urination, an increase in UTI’s and skin/ear infections, a pot-bellied appearance, thinning skin, and hair loss. In the treatment of some diseases, the risk of iatrogenic Cushing’s disease is unavoidable. To minimize this risk, corticosteroid doses are tapered down over time, or several different drugs may be used in combination.

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    What Side Effects Can Corticosteroids Cause

    Corticosteroids may have both short- and long-term side effects that cause different problems in your dog.

    Short-term side effects

    Short-term side effects are those that we expect a dog to experience when initially placed on corticosteroids. These side effects depend both on the type of steroid prescribed and on the dosage administered, and include:

    • increased thirst and urination
    • development or worsening of infections
    • vomiting or nausea

    Some pre-diabetic dogs may become diabetic with corticosteroid usage. In many of these cases, the diabetes resolves once the steroid is discontinued.

    If any of these side effects occur, they can often be eliminated by lowering the dosage or frequency of administration. In some cases, your veterinarian may prescribe another type of corticosteroid in an attempt to reduce the side effects. The objective is to determine the lowest dose of medication that controls the condition with the least number of side effects.

    Long-term side effects

    Some diseases and medical conditions require long-term treatment with corticosteroids, at either an anti-inflammatory dose or an immunosuppressive dose. When corticosteroids will be used for more than three to four months, particularly at immunosuppressive doses, additional side effects become a concern. The most commonly seen long-term side effects include:

    Side Effects Of Zentonil

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    While Zentonil is considered safe for use, some pets may show signs of vomiting. If the vomiting lasts for more than a day, you must seek medical care. Besides this, the supplement may have certain drug interactions when combined with a few medications or over the counter drugs. To prevent this from happening you must keep your vet informed about all other medications that you are giving your pet even if theyre herbal remedies or homeopathic preparations.

    Since Zentonil is nutrient supplement and not a medication, it doesnt have to undergo strict testing. Therefore the product may not have standardized production. Its thus best to buy it from the vet to protect your dogs health.

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    Hepato Trubenefitstm Vs The Leading Liver Supplements

    Other liver supplements contain SAMe, an expensive, difficult to manufacture, unstable ingredient. SAMe products cant be given with food, which can be difficult for pets. Hepato TruBenefitsTM uses Glutathione, an antioxidant that can be given with food. The result is a less expensive product that is easier for your pet to take.

    Rupture Of The Gallbladder Or Bile Duct

    Rupture of the gallbladder or bile duct is most often due to gallstone obstruction, inflammation of the gallbladder, or blunt trauma. Rupture of the bile duct may also occur as a result of cancer or certain parasites. Rupture leads to leakage of bile into the abdomen, causing a serious condition called bile peritonitis, which may be fatal if the rupture is not repaired. Treatment includes surgery, which consists of placing a stent in the bile duct, removing the gallbladder, or connecting the gallbladder with the small intestine.

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    Silybin As A Detoxifying And Hepatoprotective Substance

    Several chemotherapeutic agents are metabolized by the liver and can exert hepatotoxicity, with the net result of drug reductions or withdrawal. Chemotherapeutic agents that are likely to produce hepatotoxicity include dactinomycin, daunorubicin, docetaxel, gemcitabine, imatinib, 6-mercaptopurine, methotrexate, and oxaliplatin. Cancer patients taking these therapies often self-medicate with milk thistle because of its reputation as a liver protectant. Clinicians also prescribe it to cancer patients for the same purpose. The rationale of milk thistle use is to provide support to the liver while it performs multiple functions, including responding to the increased metabolic demands caused by tumor growth, assisting in metabolizing products generated when a tumor is killed or reduced by chemotherapy and radiation, and aiding in the processing of drugs prescribed to cancer patients.

    The Use Of Silybin In The Clinical Setting: Efficacy And Suggestions

    Apoquel for Dogs and Cancer Dr. Nancy Reese Q& A

    The use of silymarin in the clinical setting has a long history in its native Mediterranean region, it has been employed for liver damage since the Greco-Roman era. As mentioned in the introduction, herbal therapy use is consistently increasing worldwide, and some of the most common herbal supplement preparations are derived from the milk thistle plant . Despite a long history of its use and the large number of people who consume this substance, no conclusive data on its clinical efficacy can be identified. In fact, only a few well designed clinical trials have been performed. Most studies have been conducted using silymarin and with inclusion of patients with alcoholic or viral cirrhosis. Stickel et al identified the 10 main controlled trials conducted in liver patients, with numbers of patients ranging from 20 to 200 and doses of silymarin ranging from 210 to 450 mg/d for 7 to 730 d. These clinical studies generally have suffered from the same shortcomings found in many other trials on herbal medicines, such as a small sample size, lack of appropriate randomization and of allocation concealment or blinding, very different periods of treatment, lack of information about type and dose of extract used as well as product characterization, ill-defined patient population, and a lack of etiology, severity of disease, and discussion of potential confounders.

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    Endocrine Diseases Affecting The Liver

    Several diseases involving the endocrine glands can cause liver problems in dogs. These diseases include diabetes mellitus Diabetes Mellitus The pancreas is composed of several types of cells that have distinct functions involved in the production of hormones and digestive enzymes. The exocrine pancreas produces enzymes that are… read more , Cushing disease Cushing Disease The pituitary gland is located near the center and bottom of the brain. It produces a number of critical hormones that control many parts of the body, including several other endocrine glands… read more , and hyperthyroidism Hyperthyroidism The thyroid gland is a 2-lobed gland in the neck. It produces iodine-containing hormones, the most important of which are T3 and T4 , which affect many processes in the body. In general, the… read more .

    Dogs with hyperadrenocorticism are likely to develop changes in the liver similar to those seen in overdoses of cortico-steroids. These problems are controlled when the underlying disorder is treated. Liver changes can also be seen in dogs with hypothyroidism.

    Other Effects On Cellular Signaling

    In cancer cells, silybin alters cell cycle regulators and induces apoptosis, both through antioxidant and anti-inflammatory properties and through the inhibition of growth factor receptor-mediated mitogenic and cell survival signaling, particularly related to the activation of tyrosine kinases. PDGF receptor , epidermal growth factor receptor , Bcr-Abl, and KIT are examples of tyrosine kinases overexpressed in most human cancers. Silymarin or silybin are particularly effective in inhibiting EGFR signaling with suppression of cyclin-dependent kinase expression and up regulation of CDK inhibitors . These effects lead to G1 and G2-M arrest in cancer cells, as recently confirmed in a model of human colon cancer. In fact, at a dose ranging from 40-75 mol/L, silybin significantly inhibited cell proliferation through cell cycle arrest via inhibition of cyclin promoter activity.

    Because it inhibits constitutive NF-B activation, silybin can induce apoptosis, consistent with a significant decrease in its nuclear level of p65 subunit. In addition, it activates caspase 3 and caspase 9 and decreases survivin levels.

    Table summarizes the main cellular signaling affected by silybin.

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