Monday, May 16, 2022

How Dangerous Is Hepatitis B

Signs And Symptoms Of Hepatitis

Is Hepatitis B dangerous in pregnancy? What is the risk of transmission? – Dr. Shefali Tyagi

If you contract hepatitis, it may present in a way that is similar to a nasty bout of a flu, says Dr. Gulati. Common symptoms of hepatitis include:

  • Fever
  • Joint pains
  • Drowsiness

Other warning signs to look out for include dark urine, light, clay-colored stools, abdominal discomfort, and jaundice, the yellowing of the whites of the eyes or the skin due to an accumulation of bilirubin.

If you have hepatitis, a simple blood test will show elevated liver enzymes. Additional blood tests can help identify which virus, if any, is to blame.

What Is Hepatitis B

Hepatitis B is an infection of your liver. Itâs caused by a virus. There is a vaccine that protects against it. For some people, hepatitis B is mild and lasts a short time. These âacuteâ cases donât always need treatment. But it can become chronic. If that happens, it can cause scarring of the organ, liver failure, and cancer, and it even can be life-threatening.

Itâs spread when people come in contact with the blood, open sores, or body fluids of someone who has the hepatitis B virus.

It’s serious, but if you get the disease as an adult, it shouldnât last a long time. Your body fights it off within a few months, and youâre immune for the rest of your life. That means you can’t get it again. But if you get it at birth, itâ unlikely to go away.

âHepatitisâ means inflammation of the liver. There are other types of hepatitis. Those caused by viruses also include hepatitis A and hepatitis C.

What Laboratory Tests Are Available For Hepatitis B

Tests are available to detect the types of antigens used to identify the hepatitis B virus. The tests determine if the virus is present in the body tissue or blood. The amount of each type of antigen present indicates how advanced the disease is and how infective the individual has become.

Other tests are available to detect the body’s reaction to the viral infection or the body’s reaction to vaccination against the virus. These tests work by measuring the number of antibodies present in the blood.

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How Is Hepatitis B Prevented

Testing & Vaccination

  • The hepatitis B vaccine offers excellent protection against HBV. The vaccine is safe and highly effective. Vaccination consists of 3 doses of vaccine over the course of 6 months. Protection lasts for 20 years to life.
  • The American Academy of Pediatrics recommends that all children should receive hepatitis B vaccine starting at birth. .
  • The CDC recommends hepatitis B vaccine for persons traveling to countries where HBV is common .
  • If you have one or more risk factors for hepatitis B infection, you should get a simple HBV blood test. The blood test will determine whether you are:
  • immune to hepatitis B or
  • susceptible to hepatitis B and need vaccination or
  • infected with hepatitis B and need further evaluation by a physician
  • The basic test for acute HBV infection is called the Hepatitis B Core IgM Antibody test. People who have acute hepatitis B show positive IgM antibodies on this test.
  • Perinatal Hepatitis

    • California law requires testing of all pregnant women for hepatitis B infection
    • If the mother is HBV-infected, she will pass the infection to the baby during the birth process, unless the baby gets immunized within hours of birth
    • Giving the infant HBIG and HBV vaccine right away will reliably prevent infection of the infant
    • Other family members should best tested for hepatitis B too, and given vaccine if they are not already infected or immune

    Healthy Habits

    After Exposure to Hepatitis B

    How Common Is Hepatitis B

    Hep B is dangerous to young children, that

    The number of people who get this disease is down, the CDC says. Rates have dropped from an average of 200,000 per year in the 1980s to around 20,000 in 2016. People between the ages of 20 and 49 are most likely to get it.

    About 90% of infants and 25-50% of children between the ages of 1-5 will become chronically infected. In adults, approximately 95% will recover completely and will not go on to have a chronic infection.

    As many as 1.2 million people in the U.S. are carriers of the virus.

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    Important Questions And Needs For Future Research

  • How does HBV establish productive infection in vivo and what is the host response early during the infection? Despite well-described information on the clinical manifestations and natural history of acute HBV infection, detailed knowledge of the virus-host interaction during this stage remains poorly defined. Advances in this area would offer a better understanding of the pathogenesis of HBV infection and its associated disease.

  • What is the immunologic basis of chronic infection and hepatocellular injury? There have been great strides in understanding the virology and immune response of HBV infection, but the molecular mechanisms whereby the host fails to clear the virus and develops chronic infection remain largely unknown. In addition, the adaptive evolution of virus under host immune pressure remains to be elucidated. Finally, the pathogenesis of various extra-hepatic manifestations associated with HBV infection is poorly understood. Further research in these areas is crucial not only in better understanding the natural history and disease progression but also in improving treatment for chronic hepatitis B.

  • Chronic Hepatitis B Complications

    Chronic hepatitis B can lead to

    • cirrhosis, a condition in which scar tissue replaces healthy liver tissue and prevents your liver from working normally. Scar tissue also partly blocks the flow of blood through the liver. As cirrhosis gets worse, the liver begins to fail.
    • liver failure, in which your liver is badly damaged and stops working. Liver failure is also called end-stage liver disease. People with liver failure may require a liver transplant.
    • liver cancer. Your doctor may suggest blood tests and an ultrasound or another type of imaging test to check for liver cancer. Finding cancer at an early stage improves the chance of curing the cancer.

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    Treatment For Suspected Exposure

    Anyone who has had potential exposure to HBV can undergo a postexposure prophylaxis protocol.

    This consists of HBV vaccination and hepatitis B immunoglobin . Healthcare workers give the prophylaxis after the exposure and before an acute infection develops.

    This protocol will not cure an infection that has already developed. However, it decreases the rate of acute infection.

    Hepatitis C: Can Be As Dangerous As Hepatitis B

    Is Hepatitis B dangerous in pregnancy ?What is the risk of transmission ? I Cloudnine Hospitals

    Hepatitis C is a Viral Infection That is Little Talked About, But Can Be As Dangerous As Hepatitis B

    Most people have head or what became in the 1980s and ’90s the dreaded AIDS virus. With time and the availability of medicines, it ceased to be a killer. However, the knowledge of it helped stem its spread. Most people, unfortunately, don’t realize that hepatitis C is also a killer, simply because not much has been said about it. In fact, it is also a virus, but is 10 times more infectious than HIV.

    Hepatitis C is transmitted through the blood, and is usually passed on to women through infected needles and sex. At-home glucometers are often shared, or sometimes a woman’s own lifestyle or her partner’s lifestyle before marriage may put her at risk, because the virus can stay in the blood for years. It is also transmitted through blood products, like in the case of a transfusion, though in the case of pregnant women, this is not so common.

    What you should do beforeA number of couples who come to me have planned pregnancies-they opt for a baby, rather than the baby just ‘happening’ to them. This not only helps family planning, but it also helps us rule out infections or treat them if present. Usually, in the first trimester, your gynecologist will ask you to do a simple blood test for HIV, hepatitis B and C. In the case of a planned pregnancy, visit your doctor beforehand and ask if you need to take these tests before you conceive. However, there is no vaccine for HCV yet.

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    Who Should Be Vaccinated For Hepatitis B

    All newborns should be vaccinated. Also, people who are under 18 who were not vaccinated at birth should also get the vaccine. Other groups who should be sure to be vaccinated are those in certain high-risk categories, such as:

    • People who have more than one sexual partner.
    • Men who have sex with men.
    • Adults with diabetes.
    • Sexual partners of infected people and people who share households with infected individuals.
    • People who are exposed to blood and other bodily fluids, including healthcare and public safety professionals, and people who work in jails and other places taking care of people who cant take care of themselves.

    Abnormalities In Heme Metabolism And Excretion

    One way to understand jaundice pathophysiology is to organize it into disorders that cause increased bilirubin production or decreased bilirubin excretion .

    Prehepatic pathophysiology

    Prehepatic jaundice is attributed to a pathological increase in bilirubin production. The pathophysiology is quite simple an increased rate of erythrocyte hemolysis increased bilirubin production increased deposition of bilirubin in mucosal tissue appearance of yellow hue.

    Hepatic pathophysiology

    Hepatic jaundice is due to significant damage to liver function hepatic cell death and necrosis occur impaired bilirubin transport across hepatocytes. Bilirubin transport across may be impaired at any point between hepatocellular uptake of unconjugated bilirubin and hepatocellular transport of conjugated bilirubin into the gallbladder. In addition, subsequent cellular due to inflammation causes mechanical obstruction of intrahepatic biliary tract. Most commonly, interferences in all three major steps of bilirubin metabolism uptake, conjugation, and excretion usually occur in hepatocellular jaundice. Thus, an abnormal rise in both unconjugated and conjugated bilirubin will be present. Because excretion is usually impaired to the greatest extent, conjugated hyperbilirubinemia predominates.

    Posthepatic pathophysiology

    PresentPresent

    Laboratory findings depend on the cause of jaundice:

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    Further Support And Information

    The Hepatitis Foundation can offer support and information on hepatitis B.

    The Hepatitis Foundation of New ZealandFreephone: 0800 33 20 10Website: www.hepfoundation.org.nzFor information about hepatitis B vaccination, consult a doctor or contact the:Immunisation Advisory CentreWebsite: www.immune.org.nz

    Where Is The Hepatitis B Virus Found And How Is It Transmitted

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    Blood is the major source of the hepatitis B virus in the workplace. It can also be found in other tissues and body fluids, but in much lower concentrations. The risk of transmission varies according to the specific source. The virus can survive outside the body for at least 7 days and still be able to cause infection.

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    Symptoms Of Hepatitis B

    Some people who are infected with the hepatitis B virus have mild, flu-like symptoms and some do not become sick at all. Children who are infected are less likely to have an illness or get sick after getting hepatitis B than adults.

    In more severe cases, hepatitis B can cause:

    • Loss of appetite.
    • Pain in the joints.
    • Jaundice .

    Normally, these health problems disappear in a few weeks, but even when the person feels much better, they may still be infectious.

    Most adults who become infected with the hepatitis B virus recover completely and do not become infected again. A few people become very ill in the time just after infection and need to go to hospital some may even die.

    How Long Before I Have Symptoms

    Many people have mild symptoms or no symptoms, which is why hepatitis is sometimes called a âsilentâ disease.

    Hepatitis A. The symptoms usually show up 2 to 6 weeks after the virus entered your body. They usually last for less than 2 months, though sometimes you can be sick for as long as 6 months.

    Some warning signs that you may have hepatitis A are:

    Hepatitis B. The symptoms are the same as hepatitis A, and you usually get them 3 months after you’re infected. They could show up, though, anywhere from 6 weeks to 6 months later.

    Sometimes the symptoms are mild and last just a few weeks. For some people, the hep B virus stays in the body and leads to long-term liver problems.

    Hepatitis C. The early symptoms are the same as hepatitis A and B, and they usually happen 6 to 7 weeks after the virus gets in your body. But you could notice them anywhere from 2 weeks to 6 months later.

    For about 25% of people who get hep C, the virus goes away on its own without treatment. In other cases, it sticks around for years. When that happens, your liver might get damaged.

    Remember, it’s possible to spread all the types of hepatitis even if you don’t show any signs of being sick.

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    This Is Why Hepatitis B Hepatitis C Are Dangerous

    Just one in 10 infected know their status and many are unaware that the inflamation of the liver is a common and treatable disease

    Hepatitis infection can happen to anyone at any time, and neednt be accompanied by shame or guilt. It is a common and treatable disease.

    More than 40 million people are victims of hepatitis in India today. Hepatitis kills 1,000 people every year. Although effective remedies are available to prevent the disease and its infection, many are not aware of its cause and symptoms.

    Hepatitis is a type of inflammation in the liver. This condition can be restricted to either or severe form and may take the form of fibrosis or liver cancer. Just one in ten people infected with the disease know their status. Effective treatments exists from basic hygiene to the hepatitis B vaccine but stigma and discrimination against patients is common.

    Only 5 per cent of those eligible for treatment actually received anti-virus showed a study. Around 94 million people were eligible for treatment in 2016, but just 4.8 million of them got it. India lacks a mechanism to compile data to give a clear picture of its prevalence.

    Causes

    Transmission

    How Is Hepatitis B Treated

    What is Hepatitis B? | How is Hepatitis B Transmitted?

    Your healthcare provider will treat you based on what type of hepatitis B you have, acute or chronic.

    Acute hepatitis B infections

    If you develop an acute form of the condition, you probably wont need medical treatment. Instead, your doctor will likely suggest that you get plenty of rest, drink lots of fluids and maintain a healthy diet to support your body as it fights off the infection.

    Chronic hepatitis B infections

    If you have chronic hepatitis B, you might be a candidate for drug therapy. Usually, drug therapy is used only if you have active liver disease. There are seven drugs that are approved by the U.S. Food and Drug Administration to treat hepatitis B. Two are injectable forms of interferon, while the five other antivirals are tablets.

    You will need to take these medications every day. They help by slowing the viruss ability to multiply in your system. This helps reduce swelling and liver damage. Youll need to be regularly monitored for early signs of liver damage and liver cancer. Your healthcare provider will want to see you once or twice a year.

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    Is There A Cure For Chronic Hepatitis B

    Currently, there is no complete cure for hepatitis B. But when managed properly, those living with the virus can expect to live a normal life. Maintaining a healthy diet and avoiding alcoholic beverages and tobacco products are crucial components in managing the disease.

    You should also visit a doctor familiar with hepatitis B at least annuallythough twice a year might be best to monitor your liver through blood tests and medical imaging. As with most diseases, detecting it early leads to a better outcome. If youre exposed to the virus, you should get an antibody injection within 12 hours of exposure.

    Acute Vs Chronic Infection

    Doctors distinguish between chronic and acute infection with hepatitis viruses. Acute infection is a short-term condition, lasting under six months. Chronic infection is a long-term condition, lasting more than six months.

    Hepatitis B infection can be either acute or chronic. Most people who get acute hepatitis B dont end up progressing to chronic hepatitis B. By contrast, acute hepatitis C tends to develop into chronic hepatitis C. Approximately 7585 percent of adults newly infected with hepatitis C develop a chronic infection, according to the CDC . Others clear the infection.

    When you get acute hepatitis C you may or may not have symptoms. Most cases of acute hepatitis C are asymptomatic, meaning people dont notice the symptoms. Symptoms are only noticeable in 15 percent of cases of acute hepatitis C.

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    Detection Of Antiviral Resistance

    National and international surveillance is performed by the CDC to determine effectiveness of the current FDA-approved antiviral flu drugs. Public health officials use this information to make current recommendations about the use of flu antiviral medications. further recommends in-depth epidemiological investigations to control potential transmission of the resistant virus and prevent future progression. As novel treatments and detection techniques to antiviral resistance are enhanced so can the establishment of strategies to combat the inevitable emergence of antiviral resistance.

    History And Physical Exam

    Hepatitis B: Causes, symptoms, and treatment

    To diagnose hepatitis, first your doctor will take your history to determine any risk factors you may have for infectious or noninfectious hepatitis.

    During a physical examination, your doctor may press down gently on your abdomen to see if theres pain or tenderness. Your doctor may also feel to see if your liver is enlarged. If your skin or eyes are yellow, your doctor will note this during the exam.

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