Thursday, September 22, 2022

Is There A Cure For Hepatitis B Virus

Treatment For Acute Hepatitis B

Hepatitis B: Treatment and care for a chronic condition

If you’re diagnosed with hepatitis B, your GP will usually refer you to a specialist, such as a hepatologist .

Many people do not have any troublesome symptoms, but if you do feel unwell, it can help to:

  • get plenty of rest
  • take over-the-counter painkillers, such as paracetamol or ibuprofen, for tummy pain
  • maintain a cool, well-ventilated environment, wear loose clothing, and avoid hot baths or showers if itching is a problem
  • take medication, such as metoclopramide, to stop you feeling sick, and chlorphenamine to reduce itching your doctor can give you a prescription for these if necessary

Most people recover completely in a couple of months, but you’ll be advised to have regular blood tests to check that you’re free of the virus and have not developed chronic hepatitis B.

Living With Hepatitis B

If you have hepatitis, you should:

  • avoid having unprotected sex, including anal and oral sex, unless you’re sure your partner has been vaccinated against hepatitis B
  • avoid sharing needles used to inject drugs with other people
  • take precautions to avoid the spread of infection, such as not sharing toothbrushes or razors with other people
  • eat a generally healthy, balanced diet there’s no special diet for people with hepatitis B
  • avoid drinking alcohol this can increase your risk of developing serious liver problems
  • speak to your doctor if you’re thinking of having a baby

People with hepatitis B can usually have a healthy pregnancy, but it’s a good idea to discuss your plans with a doctor first as you may need extra care and your medications may need to be changed.

There’s a risk of pregnant women with hepatitis B passing the infection on to their child around the time of the birth, but this risk can be reduced by ensuring the baby is vaccinated shortly after they’re born.

Page last reviewed: 30 January 2019 Next review due: 30 January 2022

Durability And Related Factors After Hbsag Clearance

When patients with HBeAg-positive CHB achieve a satisfactory antiviral treatment endpoint , the clinical recurrence is 2040%, and the virological recurrence can be as high as 8090% after drug withdrawal . Because the safety of drug withdrawal is uncertain, HBsAg clearance is recommended as the ideal treatment endpoint for CHB patients. The accessibility and rate of HBsAg clearance was mentioned above, but the durability of HBsAg clearance after treatment cessation remains controversial.

HBeAg status should also receive attention in the pursuit of HBsAg clearance. The clearance of HBsAg in most patients is based on HBV DNA suppression and HBeAg seroconversion, but a few patients exhibit different HBsAg response patterns, such as HBsAg clearance without HBeAg seroconversion. Only HBsAg clearance based on HBV DNA suppression and HBeAg seroconversion is safe for drug withdrawal .

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Hbsag Clearance After Na Treatment

There are few large or conclusive studies on the clearance of HBsAg after NA treatment, and some of these studies are single-centre retrospective studies. Kim et al. reported a clearance rate of 1% or less in 110 CHB patients who were treated with ETV/LAM for approximately 1 year. A retrospective study by Yip et al. reported an HBsAg clearance rate of 2.1% after an average follow-up of 4.8 years in 20,263 CHB patients treated with ETV/TDF for longer than 6 months. Wong et al. retrospectively evaluated 1072 CHB patients on antiviral therapy for approximately 6 years and found an HBsAg clearance rate of 4.58%. This study found no significant difference in the clearance rate between HBeAg-positive and HBeAg-negative patients, but the rate in patients with cirrhosis was significantly lower than patients without cirrhosis . These results suggested that the clearance rate of non-cirrhosis patients was higher after NA treatment, which is not consistent with the results of patients who experienced spontaneous clearance. Compared to patients with normal baseline ALT, patients with higher ALT levels had significantly higher rates of achieving HBsAg clearance. In general, the clearance rate may increase with the extension of treatment in CHB patients, but the overall rate with currently available NA treatment is low. The HBsAg clearance rates were 1.45.1% after an average follow-up of 27 years after NA treatment .

How Is Acute Hepatitis B Treated

Symptoms of Hepatitis B

Acute hepatitis B doesnt always require treatment. In most cases, a doctor will recommend monitoring your symptoms and getting regular blood tests to determine whether the virus is still in your body.

While you recover, allow your body to rest and drink plenty of fluids to help your body fight off the infection. You can also take an over-the-counter pain reliever, such as ibuprofen , to help with any abdominal pain you have.

See a doctor if your symptoms are severe or seem to be getting worse. You may need to take a prescription antiviral medication to avoid potential liver damage.

Like acute hepatitis B, chronic hepatitis B may not require medical treatment to avoid permanent liver damage. In some patients, monitoring symptoms and getting regular liver tests is appropriate.

Treatment generally involves antiviral medications, such as:

  • peginterferon alfa-2a injections
  • antiviral tablets, such as tenofovir or entecavir

Antiviral medications can help to reduce symptoms and prevent liver damage. But they rarely completely get rid of the hepatitis B virus. Instead, the goal of treatment is to have the lowest viral load possible. Viral load refers to the amount of a virus in a blood sample.

Theres no cure for hepatitis B, but the condition is easily preventable by taking a few precautions. Hepatitis B is often spread through sexual contact, shared needles, and accidental needle sticks.

You can reduce your risk of developing hepatitis B or spreading the virus to others by:

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How Do You Get Hepatitis B

Hepatitis B is really contagious. Its transmitted through contact with semen , vaginal fluids, and blood. You can get it from:

  • having vaginal, anal, or oral sex

  • sharing toothbrushes and razors

  • sharing needles for shooting drugs, piercings, tattoos, etc.

  • getting stuck with a needle that has the Hep B virus on it.

Hepatitis B can also be passed to babies during birth if their mother has it.

Hepatitis B isnt spread through saliva , so you CANT get hepatitis B from sharing food or drinks or using the same fork or spoon. Hepatitis B is also not spread through kissing, hugging, holding hands, coughing, sneezing, or breastfeeding.

Treatment For Suspected Exposure

Anyone who has had potential exposure to HBV can undergo a postexposure prophylaxis protocol.

This consists of HBV vaccination and hepatitis B immunoglobin . Healthcare workers give the prophylaxis after the exposure and before an acute infection develops.

This protocol will not cure an infection that has already developed. However, it decreases the rate of acute infection.

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How Is It Treated

In most cases, hepatitis B goes away on its own. You can relieve your symptoms at home by resting, eating healthy foods, drinking plenty of water, and avoiding alcohol and drugs. Also, find out from your doctor what medicines and herbal products to avoid, because some can make liver damage caused by hepatitis B worse.

Treatment for chronic hepatitis B depends on whether your infection is getting worse and whether you have liver damage. Most people with chronic hepatitis B can live active, full lives by taking good care of themselves and getting regular checkups. There are medicines for chronic hepatitis B, but they may not be right for everyone. Work with your doctor to decide if medicine is right for you.

Sometimes, chronic hepatitis B can lead to severe liver damage. If this happens, you may need a liver transplant.

Is The Vaccine Safe

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The vaccine is safe. It’s been used in Canada for many years and it’s one of the safest vaccines around. It might cause minor side effects – maybe redness, warmth or slight swelling where the needle went in, maybe tiredness or slight fever for a day or so. More serious reactions occurring within 15 days should be reported to your doctor or local health unit. These include breathing trouble, swelling of face or mouth, a fever over 39°C, hives or rashes.

The risk from hepatitis B is much greater than the risk from the vaccine, however, some people should not have this vaccine.

You won’t be vaccinated if you have a fever or anything more serious than a minor cold. Tell your doctor if you’ve had a past allergic reaction to a vaccine. You should always discuss the benefits and risks of any vaccine with your doctor.

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Hepatitis B Symptoms & Treatment

FAST FACTS

  • Hepatitis B is a virus found in infected blood, semen and vaginal fluids.
  • Its a sexually transmitted infection that can be passed on through unprotected sex. You can also get it from contaminated needles and syringes. Its also commonly passed on from a mother to her baby during birth.
  • There is a vaccine to prevent hepatitis B, which is routinely offered to infants as well as at-risk groups.
  • You can prevent hepatitis B by practising safer sex, never sharing needles and syringes, and avoiding unlicensed tattoo parlours and acupuncturists.
  • Most people dont need treatment for acute hepatitis B. If the infection becomes chronic, there is no cure, but it can be managed with treatment.

Why Should My Baby Get The Hepatitis B Shot

  • Protects your child from against hepatitis B, a potentially serious disease.
  • Protects other people from the disease because children with hepatitis B usually dont have symptoms, but they may pass the disease to others without anyone knowing they were infected.
  • Prevents your child from developing liver disease and cancer from hepatitis B.
  • Keeps your child from missing school or child care and you from missing work.

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What Are The Symptoms Of Hepatitis B

Many people with hepatitis B dont have any symptoms. If you do get symptoms you may not notice them until two or three months after infection and they can last up to three months. There are two types of infection acute and chronic.

Acute symptoms include:

  • flu-like symptoms, including tiredness, fever and aches and pains
  • feeling and/or being sick
  • jaundice, meaning your skin and the whites of your eyes turn yellow
  • dark urine
  • pale faeces .

People who cant fight off acute infection after six months, such as babies, young children and people with a weakened immune system because of HIV, can go on to develop chronic hepatitis B. This is when people are at higher risk of liver failure, liver disease and cancer of the liver.

How You Can Catch Hepatitis B

Hepatitis B vaccine: Safety and side effects

You can get hepatitis B through the blood and other body fluids from an infected person. It’s primarily a sexually transmitted disease, but you can also pick it up through used needles, and through body/ear piercing or tattooing with dirty equipment. An infected mother can pass it to her child at birth. Health care and emergency service workers can get it from needle stick injuries and blood splashes in the eyes, nose, mouth or on broken skin. You can’t get hepatitis B from someone coughing, or from hugging or using the same dishes.

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How Do You Test For Hepatitis B

A simple blood test carried out by a healthcare professional will show whether you have the virus. You may also be given extra tests to see if your liver is damaged.

If youve got hepatitis B you should be tested for other STIs. Its important that you tell your recent sexual partner/s so they can also get tested and treated. Many people who have hepatitis B dont notice anything wrong, and by telling them you can help to stop the virus being passed on. This can also stop you from getting the infection again.

Are Alternative Medicines Available

Some people believe certain forms of alternative medicine help cure hepatitis C.

However, the National Center for Complementary and Integrative Health reports that there are no effective, research-proven forms of alternative treatment or complementary medicine for hepatitis C.

Silymarin, also known as milk thistle, is an herb commonly suggested to help cure hepatitis C liver disease. But a rigorous did not find any beneficial effects from this supplement.

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Treatment Options For Hepatitis B

People living with chronic hepatitis B infection should expect to live a long and healthy life. There are decisions people can make to protect their livers such as seeing a liver specialist or health care provider regularly, avoiding alcohol and tobacco, and eating healthy foods. There are also approved drugs for both adults and children that control the hepatitis B virus, which helps reduce the risk of developing more serious liver disease, but there is still no complete cure.

Current treatments for hepatitis B fall into two general categories:

  • Immune modulator Drugs These are interferon-type drugs that boost the immune system to help get rid of the hepatitis B virus. They are given as a shot over 6 months to 1 year.
  • Antiviral Drugs These are drugs that stop or slow down the hepatitis B virus from reproducing, which reduces the inflammation and damage of your liver. These are taken as a pill once a day for at least 1 year and usually longer.

It is important to know that not everyone with chronic hepatitis B infection needs to be treated. This can be difficult to accept when first diagnosed because taking a drug to get rid of the virus seems like the first step to getting better. Current treatments, however, are generally found to be most effective in those who show signs of active liver disease .

Hepatitis B Drug Watch

Visit the HBF Drug Watch for a complete list of the approved treatments for hepatitis B and promising new drugs in development.

How Can Hepatitis B Be Prevented

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A safe and effective vaccine to prevent hepatitis B is available. The hepatitis B vaccine is recommended for people in high-risk settings who have not already been infected and for infants who are born to infected mothers. It is recommended that all children and adolescents be vaccinated against hepatitis B along with their routine childhood immunizations beginning at birth. A special hepatitis B immune globulin is also available for people who are exposed to the virus. In the event of exposure to hepatitis B, consult a doctor or the local health department.

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What Do I Need To Know About Having Hepatitis B

If you have chronic hepatitis B, getting the right medical care can help you stay healthy. Taking good care of your liver is important. Talk with your doctor before you take any prescription medication, over-the-counter drugs, vitamins, or nutritional supplements to make sure they wont hurt your liver. You should also stay away from alcohol, because drinking can damage your liver.

When Should You Call Your Doctor

If you see a person with hepatitis B become unconscious, call 911 or other emergency services.

if you have been diagnosed with hepatitis B and you have severe dehydration or these signs of liver failure:

  • Extreme irritability.
  • Extreme sleepiness.
  • Swelling of the arms, legs, hands, feet, belly, or face.
  • Heavy bleeding from the nose, mouth, or rectum , or under the skin.
  • Yellowing of the skin and the whites of the eyes.
  • You have risk factors for hepatitis B, such as handling blood or body fluids as a routine part of your job or having many sex partners.
  • You have any symptoms of hepatitis B .
  • Someone in your household has been diagnosed with hepatitis B.
  • Your sex partner has been diagnosed with hepatitis B.
  • You have been bitten by or exposed to the blood or body fluids of someone who has hepatitis B.

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Hepatitis B And Pregnancy

If youâre pregnant, you might pass the virus to your baby at birth. Itâs less likely to happen during your pregnancy.

If your baby gets the virus and isnât treated, they could have long-term liver problems. All newborns with infected mothers should get hepatitis B immune globulin and the vaccine for hepatitis at birth and during their first year of life.

What To Think About

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  • Interferons have common side effects, including fever, headaches, and hair loss. They may also cause mental problems or make them worse.
  • If you have cirrhosis, you cannot use interferons. But you can use adefovir, entecavir, lamivudine, telbivudine, and tenofovir.
  • After any kind of treatment for hepatitis B, the virus may become active again .

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What Problems Can Hepatitis B Cause

Hepatitis B is a serious infection. It can lead to cirrhosis of the liver, liver failure, or liver cancer, which can cause severe illness and even death.

If a pregnant woman has the hepatitis B virus, her baby has a very high chance of having it unless the baby gets a special immune injection and the first dose of hepatitis B vaccine at birth.

Sometimes, HBV doesn’t cause symptoms until a person has had the infection for a while. At that stage, the person already might have more serious problems, such as liver damage.

Who Is Most Affected

In the United States, rates of new HBV infections are highest among adults aged 40-49 years, reflecting low hepatitis B vaccination coverage among adults at risk. The most common risk factor among people with new HBV infections is injecting drugs, related to the opioid crisis.

The highest rates of chronic hepatitis B infection in the United States occur among foreign-born individuals, especially people born in Asia, the Pacific Islands, and Africa. Approximately 70% of cases in the United States are among people who were born outside of the United States. CDC developed this map of the geographic distribution of hepatitis B around the world – PDF. Other groups who have higher rates of chronic HBV infection include people who inject drugs and men who have sex with men.

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