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What Is Hepatitis B Surface Antibody Quantitative

For Patients With Chronic Hbv

Hepatitis B Titer – Hep B Surface Antibody Test Results Overview

Reducing the risk of liver damage

  • Have liver enzymes monitored every 6-12 months.
  • Reduce or eliminate alcohol.
  • Stop smoking, as it increases the risk of liver cancer.
  • You may drink coffee 3 or more cups per day may reduce the risk of liver cancer.Endnote 21
  • Maintain a healthy weight.
  • Get vaccinated against hepatitis A if you are not already immune â talk to your HCP or contact your local public health department.
  • Stick to your medication schedule and your regular lab testing and follow-up visits.
  • Tell your HCP before starting any immunosuppressive therapy.

About medications for patients with cirrhosis

  • Avoid aminoglycosides , benzodiazepines, and narcotics including codeine .
  • Whenever possible, avoid ASA or NSAIDs. Acetaminophen, oral contraceptive pills, and statins are safe to use.
  • Do not drink alcohol.
  • If you require surgery, discuss it with your specialist first.
  • If you have black stools, call your specialist immediately or go to the ER.
  • Tell your HCP about any complementary/alternative therapies or over the counter supplements including herbal remedies that you are taking.
  • Follow your HCPâs advice on how frequently you require abdominal ultrasounds.

Living well with HBV

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Question 7 Is Hepatitis B Surface Antibody Antibody Always Acquired After A Completed Vaccination Protocol

No. After 3 intramuscular doses of vaccine, > 90% of healthy adults and > 95% of those < 19 years of age develop immunity .1 However, there is an age-specific decline in development of immunity. After age 40 years, about 90% of people become immune, but by age 60 years, only 75% of people become immune.1 Larger vaccine doses or an increased number of doses are required to induce immunity in many hemodialysis patients and in other immunocompromised people.1

References

  • Centers for Disease Control and Prevention. Hepatitis B. . Accessed May 30, 2013.
  • Ganem D, Prince AM. Hepatitis B virus infectionnatural history and clinical consequences. N Engl J Med. 2004 350:1118-1129.
  • This FAQ is provided for informational purposes only and is not intended as medical advice. A clinicians test selection and interpretation, diagnosis, and patient management decisions should be based on his/her education, clinical expertise, and assessment of the patient.Document FAQS.105 Revision: 0

    Hepatitis B Surface Antibody

    Hepatitis B Surface Antibody
    Description

    The Quantitative detection Hepatitis B virus Surface IgG antibody in human sera using the FDA approved Abbott ARCHITECT AUSAB-DIL test two-step chemiluminescent immunoassay.

    In the first step, sample, assay diluent, and recombinant Hepatitis B surface Antigen coated paramagnetic microparticles are combined. Anti-HBs present in the sample binds to the rHBsAg coated microparticles. In the second step, rHBsAg acridinium-labeled conjugate is added, which binds to IgG anti-HBs. Then pre-trigger and trigger solutions are added to the reaction mixture. The resulting chemiluminescent reaction is measured as relative light units .

    A direct relationship exists between the amount of anti-HBs in the sample and the RLUs. The concentration of anti-HBs in the sample is determined using an active ARCHITECT AUSAB calibration curve. Results are reported as mIU/mL.

    For Batteries containing HBSAb see:

    Hepatitis B Antibodies , Quantitative detection of Hepatitis B virus Surface IgG antibody and Hepatitis B virus Core IgG and IgM antibodies

    Hepatitis B Battery , Quantitative detection of Hepatitis B virus Surface IgG antibody , Qualitative detection of Hepatitis B virus Surface Antigen and Qualitative detection of Hepatitis B virus Core IgG and IgM antibodies

    Hepatitis B Surface Antigen & Antibody , Quantitative detection of Hepatitis B virus Surface IgG antibody and Qualitative detection of Hepatitis B virus Surface Antigen

    Synonyms

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    Additional Specimen Collection Information

    Collect blood in a lithium heparin, green-top, EDTA purple-topor red-top tube. PST and SST are acceptable. Serum orplasma should be separated from contact with the cells within 2hours of collection. Specimens not centrifuged within 4 hours ofcollection may be rejected. Refrigerate the specimen if unable toassay within 8 hours of collection. Samples with > 1+ lipemiamust be cleared prior to analysis.

    Discussing Screening Results With Clients

    Hepatitis B Antibody, Quantitative

    The medical personnel who ordered or arranged the screening test, not counselors, usually explain the results. Hepatitis screening should be part of the intake physical examination in an opioid treatment program, and medical personnel may report the results. However, the client may want to discuss the results with the counselor or ask the counselor questions.

    Anxiety might interfere with some clients ability to comprehend or retain information, which might need to be repeated.

    Suggestions for conversations with clients when the test results are negative include the following:

    • Explain results clearly and simply: So the HCV screening result was negative? This means that, as of 6 months ago, you did not have .
    • Emphasize that a negative result to an HCV test does not indicate to and that the client should take precautions to avoid . If a relapse to drug use occurs, advise clients to avoid sharing any drug paraphernalia or equipment. Specify that this includes cookers, cotton, water, needles, syringes, pipes, and straws.
    • Emphasize the importance of getting HAV and HBV vaccinations. Provide information about the availability of low- or no-cost vaccinations.

    Clients whose screening test results are positive for will need additional tests and examinationsusually with doctors who specialize in diseases of the liver to get accurate diagnoses and to determine their health status and the extent of liver damage. These tests are described in .

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    Very Easy And Quick Result

    Very satisified with my experience. Went to the website and choose my test, got the prescription thru email with in 30 minutes. Got blood draw the following morning at Lab Corp. Then got the result the following day thru secured emai link. Thats only 48 hrs from log in to result. Compared to my MD office which is 10 days to get the result and after multiple calls and only to find out that they performed a wrong lab test. Here you know what test they are performing since you are the one choosing.

    What Is The Purpose Of A Hepatitis B Test

    Hepatitis B test is performed to detect, classify, and treat hepatitis B virus infection.

    Hepatitis B blood tests involve the measurement of several HBV-specific antigens and antibodies. In addition, HBV blood tests also include liver enzymes and liver function tests to assess and monitor the condition of the liver and provide appropriate treatment.

    The HBV specific tests include the following:

    • HBsAg: HBsAg is an antigen found on the surface of hepatitis B virus. HBsAg may be detected in the blood any time after 1 week post-exposure to HB virus, but usually appears after 4 weeks.
    • Anti-HBs: Anti-HBs are antibodies produced by the bodys immune system to fight HBsAg. Anti-HBs from a prior infection or vaccination provides immunity against further infection.
    • Hepatitis B core antigen : HBcAg is an antigen found in the core layer which covers the hepatitis B viral DNA.
    • Hepatitis B core antibody : Anti-HBc is the antibody that fights HBcAg. Anti-HBc is the first detectable antibody after HBV infection. There are two kinds of Anti-HBc:
    • Immunoglobulin M hepatitis B core antibody : IgM anti-HBc indicates acute or reactivated recent infection within the previous 6 months.
    • Immunoglobulin G hepatitis B core antibody : IgG anti-HBc may indicate previous or chronic infection. Once present, IgG anti-HBc persists for a lifetime.
  • HBV DNA: HBV DNA is the genetic material of the HB virus and this test is a measure of the actual viral load and replication.
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    Hbv Dna Hbv Genotype And Hbv Drug Resistance Assays

    Specimen: Serum or plasma

    Container: Red-top tube, yellow-top tube , gel-barrier tube, plasma preparation tube, or lavender tube

    Collection method: Routine venipuncture

    The specimen should be transfused to separate plasma/serum from cells within 6 hours and kept frozen when testing cannot be done promptly.

    The tests use PCR amplification, DNA probe hybridization, and sequencing method.

    Kinetics And Risk Of De Novo Hepatitis B Infection In Hbsagnegative Patients Undergoing Cytotoxic Chemotherapy

    Quantitative HBsAg and its Role in Chronic Hepatitis B Patient Management
    • CheeKin HuiCorrespondenceAddress requests for reprints to: CheeKin Hui, MD, University of Hong Kong, Queen Mary Hospital, Department of Medicine, 102 Pokfulam Road, Hong Kong SAR, China. fax: 2281 84030.Centre For The Study of Liver Diseases, The University of Hong Kong, Hong Kong SAR, ChinaResearch Centre For Infection and Immunity, The University of Hong Kong, Hong Kong SAR, China
    • HaiYing ZhangAffiliationsCentre For The Study of Liver Diseases, The University of Hong Kong, Hong Kong SAR, ChinaResearch Centre For Infection and Immunity, The University of Hong Kong, Hong Kong SAR, China
    • YuiHung YuengAffiliationsCentre For The Study of Liver Diseases, The University of Hong Kong, Hong Kong SAR, ChinaResearch Centre For Infection and Immunity, The University of Hong Kong, Hong Kong SAR, China
    • John M. LukAffiliationsCentre For The Study of Liver Diseases, The University of Hong Kong, Hong Kong SAR, ChinaDepartment of Surgery, Queen Mary Hospital, The University of Hong Kong, Hong Kong SAR, China
    • George K.K. LauAffiliationsCentre For The Study of Liver Diseases, The University of Hong Kong, Hong Kong SAR, ChinaResearch Centre For Infection and Immunity, The University of Hong Kong, Hong Kong SAR, China

    Background & Aims:Methods:Results:

    Abbreviations used in this paper:

    Lancet.J Hepatol.

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    Understanding Of Lab Tests Results

    Please visit the site associated with The American Association for Clinical Chemistry for better understanding of tests. There you will find the most detailed and full information regarding lab tests. In common questions tab you will find answers on the most common questions.

    In addition, you can use a special form to ask the question. It is useful, if there is no answer on your question on the web site. A laboratory scientist will answer your question. It is a part of voluntary service provided by the American Society for Clinical Laboratory Science.

    Laboratory Findings And Diagnostic Tests

    Serum HBsAg and anti-HBs are the most useful screening tests for chronic HBV infection or immunity to HBV. HBsAg is present in most chronically infected persons. Lack of anti-HBs in an unvaccinated HBsAg-negative person indicates susceptibility to HBV infection.3

    Screening for HBsAg is recommended at the first prenatal visit for all pregnant women.3,109 Women in labor without HBsAg test information should have HBsAg serology on arrival. In addition, pretested women who have a history of certain risk factors should be retested at the time of admission to the hospital for delivery.3,110

    Fabrizio Fabrizi MD, ⦠Paul Martin MD, in, 2017

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    Negative But Other Hepatitis Tests Are Positive

    Your HBsAb test may be negative even when other hepatitis B tests are positive, showing active or chronic infection. Further testing is necessary, especially for the hepatitis B surface antigen , which shows that the virus itself is circulating in your bloodstream and that you have an active or chronic infection.

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    Results And Next Steps

    Quantitative hepatitis B core antibody levels in the natural history of ...

    The results of a hepatitis B titer panel can help a doctor determine a persons hepatitis B status. The results can be confusing if a person has never been through this type of testing before, but the doctor can explain the findings.

    The results for the titer come back as either negative or positive on each subtest of the panel. Positive means that the virus or antibodies showed up on the test, while negative means that they did not.

    The following table outlines what positive and negative results mean on different parts of the test and the possible next steps.

    The information comes from the Immunization Action Coalition:

    Test

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    Question 1 What Is The Clinical Indication For Hepatitis B Surface Antibody Quantitation

    Hepatitis B surface antibody quantitation is used to determine hepatitis B immune status, ie, to determine if the patient has developed immunity against the hepatitis B virus. Such immunity may develop following exposure to the hepatitis B virus or its vaccine.

    Patients at higher risk of exposure to the virus include:

    • Infants born to infected mothers
    • Sex partners of infected persons
    • People with more than 1 sex partner in the last 6 months
    • People with a history of sexually transmitted infection
    • Men who have sex with men
    • Injection drug users
    • Household contacts of an infected person
    • Healthcare and safety workers who have contact with blood and body fluids
    • People who have lived or traveled in an area in which hepatitis B is common
    • People who live or work in a prison

    Testing is not recommended routinely following vaccination. It is advised only for people whose subsequent clinical management depends on knowledge of their immune status. These people include:

    • Chronic hemodialysis patients
    • Immunocompromised people, including those with HIV infection, hematopoietic stem-cell transplant recipients, and people receiving chemotherapy
    • Infants born to women who test positive for the hepatitis B surface antigen
    • Sex partners of people who test positive for the hepatitis B surface antigen
    • Healthcare and public safety workers who have contact with blood or body fluids

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    How Much Does The Test Cost

    The cost of hepatitis B testing depends on the tests that are performed, where the test is conducted, and a patients health insurance coverage. When testing is ordered by a doctor, patients with health insurance may find it helpful to discuss the cost of testing with their health insurance company as they may be responsible for testing costs as well as other out-of-pocket costs such as copays and deductibles.

    For patients without health insurance or for whom insurance doesnt cover the cost of testing, it may be helpful to discuss the cost of hepatitis B testing with a doctor or hospital administrator.

    The cost of at-home hepatitis B testing starts around $45. At-home test kits may also test for additional types of viral hepatitis in the same sample. The cost of test panels that look for more than one type of viral hepatitis start around $80.

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    Preparation Prior To Transport

    Using T-cell engager antibodies to treat chronic viral hepatitis B and HBV-associated HCC

    Label the specimen container with the patients full name, date of collection and one other unique identifier such as the patients date of birth or Health Card Number. Failure to provide this information may result in rejection or testing delay.

    Centrifuge if using SST. Place specimen in biohazard bag and seal. Specimens should be stored at 2-8ÃðC following collection.

    Specimens more than the following number of days post collection will not be tested:

    • > 6 days for Hepatitis B surface antigen
    • > 7 days for Hepatitis B e Antigen and Hepatitis B e Antibody
    • > 10 days for Hepatitis B core Antigen and Hepatitis B surface Antibody

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    Hepatitis B Surface Antibody Positive

    Hepatitis B Surface Antigen Options

    Hepatitis B Surface Antigen
    Quick Links:

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    What Is the Difference Between a Hepatitis B Surface Antigen Test and a Hepatitis B Antibody Test?

    The hepatitis B surface antigen test can detect current hepatitis B infection, while the hepatitis B antibody test checks for the antibodies that are presumed to provide immunity to hepatitis B.

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    When Should Someone Get a Hepatitis B Surface Antigen Test?

    If someone is suspected to have hepatitis B, this test is intended to identify a chronic or current infection.

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    What Does a Positive Hepatitis B Surface Antigen Test Mean?

    A positive test means the person is currently infected or has a chronic infection of hepatitis B. This means that the person has the hepatitis B virus in their blood and can be contagious.

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    About Our Other Services

    For industries that require specific occupational health testing, such as healthcare, construction, and manufacturing, Health Street offers quick and easy scheduling. Simply enter your ZIP code and choose the location nearest to you or the person being tested. When the registration process has been completed, we will email you the registration barcode to and a map to the facility.

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    Hepatitis B Surface Antibody Immunity Quantitative

    CPT Code: 86317Includes: Hepatitis B Surface Antibody Immunity, QuantitativeABN Requirement: No Alternative: EDTA tube

    Collection:

  • Collect and label sample according to standard protocols.
  • Gently invert tube 5 times immediately after draw. DO NOT SHAKE.
  • Allow blood to clot 30 minutes.
  • Centrifuge for 10 minutes.
  • Collect and label sample according to standard protocols.
  • Gently invert tube 10 times immediately after draw. DO NOT SHAKE.
  • Centrifuge specimen for 10 minutes.
  • Pre-squeeze transfer pipet bulb and draw off approximately 2/3 of the upper plasma.Note: This ensures that the buffy coat and red cells remain undisturbed.
  • Aliquot plasma into transport tube labeled as EDTA Plasma and cap tightly. Discard original tube.
  • Transport: Store specimen at 2ðC to 8ðC after collection and ship the same day per packaging instructions included with the provided shipping box.

    Stability:

    Ambient : 5 daysRefrigerated : 14 daysFrozen : 30 days

    Causes for Rejection: Improper labeling samples not stored properly samples older than stability limits gross hemolysis gross lipemia

    Methodology: Immunoassay

    Turn Around Time: 1 to 3 days

    Reference Range: 10 mIU/mL

    Clinical Significance: This assay is used to determine immune status for Hepatitis B as 10 mIU/mL as per CDC Guidelines.

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