Medical Treatment For Hepatitis A B & C
Treatment for hepatitis A, B, or C is based on which type of hepatitis is present in the bloodstream and the severity of the resulting liver damage. Depending on the results of diagnostic tests, our specialists at NYU Langone may recommend antiviral medication to stop the virus from replicating and protect your liver from further damage.
Treatment Of Hepatitis C
Hepatitis C is treated with antiviral medications that aim to clear the virus from your body.
New all-tablet treatments have greatly improved the outcomes for people with hepatitis C. These treatments can cure more than 95% of individuals with chronic hepatitis C. There are several new tablets that are used in combination to treat all hepatitis C strains . They are effective for people with no liver damage and those who have more advanced liver damage or cirrhosis.
These new tablet medications are available and subsidised on the Pharmaceutical Benefits Scheme, and can be prescribed by specialists, general practitioners and specialised nurse practitioners.
There are no restrictions on accessing treatment it is available for all adults with a Medicare card. People under 18 are able to access treatment and it is recommended they are referred to a pediatrician experienced in the treatment of hepatitis C.
For more information on the new medications for the treatment of hepatitis C, see our video: Hepatitis C Cure what it means for Victorians.
If your doctor does not know about the new treatments, you can call the LiverLine on for information, and to find a GP who can help you.
Talk with your doctor about treatment options and the potential for interactions with other medications, herbal preparations and other drugs. If you take prescribed medication this will be managed so you can access treatment.
In general, if you have hepatitis C you will feel better if you:
Formation Of Hcv Infection Foci In A Cell Density
Formation of HCV infection foci and density-dependent HCV transfer. Huh7.5.1 cells were inoculated with culture medium , JFH1 virus at a high MOI of 0.4 , or JFH1 virus at a low MOI of 4 × 104 , cultured for 3 days, and immunostained for HCV core protein , followed by DAPI counterstaining . Huh7.5.1 cells were inoculated with culture medium or HCV JFH1 stock at an MOI of 0.05. At day 1 postinfection, the infected cells were replated at different densities, which gave rise to 30%, 50%, 70%, 85%, and 100% confluence at 3 days postreplating, at which time the cells were harvested and analyzed by Western blotting against HCV core protein , immunostained for HCV core protein and DAPI , counted for core protein-positive cells under a fluorescence microscope , or analyzed by flow cytometry for core protein-positive cells . Rel., relative values .
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Sharing Personal Care Items
The chances of spreading hepatitis C within your household are low but possible. To be safe, don’t share personal care items that could be contaminated with blood, Lee says. These include razors, toothbrushes, cuticle scissors, and nail clippers.
In addition, be mindful when you go to nail salons or barbershops, where the same tools are used on all customers. A study published in the November-December 2014 issue of the Journal of Public Health Management & Practice found that while regulations to safeguard the public exist in most states, it’s unknown how many businesses comply with them. Ask about tool-sterilization procedures before you frequent these establishments. You can also bring your own nail care supplies.
Coculture Assay And Transwell Assay
In the coculture assay, Huh7.5.1 cells were infected with HCV for 3 days and used as the donor cells. The donor cells or the target cells were first labeled with PKH26 or CMFDA according to the manufacturer’s instructions. Briefly, cells were trypsinized and labeled with 2 M PKH26 for 5 min at room temperature, followed by incubation with 1% FBSphosphate-buffered saline to stop the labeling reaction and four extensive washes to remove any residual dye. Alternatively, media containing 1.25 M or 5 M CMFDA were directly added to cells growing in culture dishes. The cells were labeled at 37°C and 5% CO2 for 30 min, followed by a medium change to normal growth medium and an extra 30 min of incubation. The labeled donor cells/target cells were counted and mixed with unlabeled target/donor cells and seeded to a 24- or 12-well plate at > 90% confluence. Unless stated otherwise, the donor cells/target cells were allowed to coincubate for approximately 20 h, followed by collection for immunostaining and flow cytometry or confocal analysis. The transwell assay was carried out in a similar fashion, except that neither donor nor target cells were labeled and the donor and target cells were seeded into the upper and lower chambers of the transwell , respectively.
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How Do You Get Hepatitis C
The hepatitis C virus is usually spread through blood-to-blood contact.
Some ways the infection can be spread include:
- sharing unsterilised needles particularly needles used to inject recreational drugs
- sharing razors or toothbrushes
- from a pregnant woman to her unborn baby
- through unprotected sex although this is very rare
In the UK, most hepatitis C infections happen in people who inject drugs or have injected them in the past.
It’s estimated around half of those who inject drugs have the infection.
What Are The Chances Of Getting Hepatitis C From Sex
Hepatitis C can spread through sexual intercourse, but it’s rare. And it’s extremely rare among monogamous couples. In fact, the CDC considers the risk of sexual transmission between monogamous couples so low that it doesn’t even recommend using condoms. Also, there’s no evidence that hepatitis C is spread by oral sex. But you should avoid sharing razors, toothbrushes, and nail clippers, and sex during menstruation.
If you have HIV or if you have multiple partners, you should take precautions. Using condoms will protect you and your partners.
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Keep Personal Items Personal
Any tools or implements that may have a bit of blood on them from infected people are potential sources of hepatitis B or C transmission. Toothbrushes, nail clippers, razors, needles, and washcloths may all contain trace amounts of blood that can transmit infection. Keep personal items such as these to yourself and never use personal items that belong to others.
How Many People Have Hepatitis C
During 2013-2016 it was estimated that about two and half million people were chronically infected with HCV in the United States. The actual number may be as low as 2.0 million or as high as 2.8 million.Globally, hepatitis C is a common blood-borne infection with an estimated 71 million people chronically infected according to the World Health Organization .
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Why Getting Tested Is Important
A blood test is one of the only ways to confirm a diagnosis of hepatitis C. Additionally, hepatitis C often has no visible symptoms for many years.
Because of this, its important to be tested if you believe youve been exposed to the virus. Getting a timely diagnosis can help ensure you receive treatment before permanent liver damage occurs.
How Do Doctors Treat The Complications Of Hepatitis C
If hepatitis C leads to cirrhosis, you should see a doctor who specializes in liver diseases. Doctors can treat the health problems related to cirrhosis with medicines, surgery, and other medical procedures. If you have cirrhosis, you have an increased chance of liver cancer. Your doctor may order an ultrasound test to check for liver cancer.
If hepatitis C leads to liver failure or liver cancer, you may need a liver transplant.
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What Is Hepatitis C
Hepatitis C is a bloodborne virus that causes inflammation of the liver. This virus is present in the blood of a person living with hepatitis C and can be spread through blood-to-blood contact.
In Australia, hepatitis C is commonly spread through sharing injecting equipment including needles, syringes and other equipment. It is not spread by kissing, hugging or sharing food.
Current treatment is effective at curing hepatitis C for more than 95% of people. Treatment cures the infection, decreases inflammation in the liver and reduces the long-term risk of health problems including chronic liver disease and liver cancer.
Accessing curative treatment also prevents transmission to others. There is no vaccine to prevent hepatitis C infection.
Preventing The Spread Of Hepatitis C
There is no vaccine available to prevent a person from being infected with hepatitis C. Recommended behaviours to prevent the spread of the virus include:
- Always use sterile injecting equipment. This can be accessed from your local needle and syringe program service.
- Avoid sharing personal items such as toothbrushes, razors, nail files or nail scissors, which can draw blood.
- If you are involved in body piercing, tattooing, electrolysis or acupuncture, always ensure that any instrument that pierces the skin is either single use or has been cleaned, disinfected and sterilised since it was last used.
- If you are a healthcare worker, follow standard precautions at all times.
- Wherever possible, wear single-use gloves if you give someone first aid or clean up blood or body fluids.
- Although hepatitis C is not generally considered to be a sexually transmissible infection in Australia, you may wish to consider safe sex practices if blood is going to be present, or if your partner has HIV infection. You may wish to further discuss this issue and personal risks with your doctor.
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What Causes Hepatitis C
The hepatitis C virus causes hepatitis C. The hepatitis C virus spreads through contact with an infected persons blood. Contact can occur by
- sharing drug needles or other drug materials with an infected person
- getting an accidental stick with a needle that was used on an infected person
- being tattooed or pierced with tools or inks that were not kept sterilefree from all viruses and other microorganismsand were used on an infected person before they were used on you
- having contact with the blood or open sores of an infected person
- using an infected persons razor, toothbrush, or nail clippers
- being born to a mother with hepatitis C
- having unprotected sex with an infected person
You cant get hepatitis C from
- being coughed or sneezed on by an infected person
- drinking water or eating food
- hugging an infected person
- shaking hands or holding hands with an infected person
- sharing spoons, forks, and other eating utensils
- sitting next to an infected person
A baby cant get hepatitis C from breast milk.18
How Is Hepatitis C Infection Prevented
Unfortunately, there is no vaccine to prevent hepatitis C. To reduce your risk of getting hepatitis C:
- Injection drug use is the most common way people get hepatitis C. Avoid injecting drugs to reduce your risk. If you do inject drugs, use sterile injection equipment. Avoid reusing or sharing.
- Avoid sharing personal care items that might have blood on them
- If you are a health care or public safety worker, follow universal blood/body fluid precautions and safely handle needles and other sharps
- Consider the risks if you are thinking about tattooing, body piercing, or acupuncture are the instruments properly sterilized?
- If youre having sex with more than one partner, use latex condoms correctly and every time to prevent the spread of sexually transmitted diseases, including hepatitis C.
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Symptoms Of Hepatitis C
It is very important to know that not everyone with hepatitis C has symptoms. The only way to know if you have hepatitis is by talking to your doctor and getting a blood test.
Many people living with hepatitis C feel well and only have symptoms once the disease has progressed and there is serious liver damage.
If you do not have symptoms this does not mean that the virus isnt causing damage.
When first infected, some people may find:
- their urine becomes dark
- their eyes and skin turn yellow
- they experience a minor flu-like illness.
These symptoms may disappear within a few weeks, but this does not necessarily mean that the infection has been cleared.
Over time, symptoms that may develop include:
- tiredness and fatigue
- flu-like symptoms
- pain in the abdomen where the liver is located
- not feeling hungry and indigestion.
Around 30% of people who have been infected may clear the virus from their blood naturally, with no treatment, within 6 months. These people no longer have the hepatitis C virus and are not infectious, but will always have hepatitis C antibodies in their blood. The presence of hepatitis C antibodies shows that someone has been exposed to the virus, but does not offer any immunity against hepatitis C. People can become reinfected after clearing the virus naturally, or after treatment.
Who Is More Likely To Get Hepatitis C
People more likely to get hepatitis C are those who
- have injected drugs
- had a blood transfusion or organ transplant before July 1992
- have hemophilia and received clotting factor before 1987
- have been on kidney dialysis
- have been in contact with blood or infected needles at work
- have had tattoos or body piercings
- have worked or lived in a prison
- were born to a mother with hepatitis C
- are infected with HIV
- have had more than one sex partner in the last 6 months or have a history of sexually transmitted disease
- are men who have or had sex with men
In the United States, injecting drugs is the most common way that people get hepatitis C.13
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How To Prevent Transmission
Between 2% and 6% of adults infected with hepatitis B virus will develop chronic hepatitis B. Chronic hepatitis B can lead to liver failure and liver cancer, so protecting yourself is important.
The hepatitis B vaccine is safe for almost everyone and about 95% effective for providing long-term protection against hepatitis B infection.
While anyone can benefit from the vaccine, people who are at a greater risk of being exposed to the virus because of their work, lifestyle or medical history are strongly encouraged to be immunized. In many countries, babies born to infected mothers get vaccinated at birth. All babies born in the United States are routinely vaccinated.
Hepatitis B immune globulin , is another way to prevent hepatitis B infection in babies born to infected mothers or after exposure to the virus. This uses concentrated antibodies to provide immediate protection. According to the Centers for Disease Control and Prevention, it is given as a shot and can provide short-term protection against hepatitis B.
Because the hepatitis B vaccine does not protect against HIV, hepatitis C or other diseases spread through sex and contact with blood, it’s still important to keep using basic protective strategies. Practicing safer sex and not sharing needles are recommended even if you’re immune to hepatitis B.
Tips For Preventing Transmission Through Sex
If youre sexually active with a person who has hepatitis C, there are ways that you can prevent contracting the virus. Likewise, if you have the virus, you can avoid infecting others.
A few steps you can take to reduce the likelihood of sexual transmission include:
- using a condom during every sexual contact, including oral sex
- learning to use all barrier devices correctly to prevent ripping or tearing during intercourse
- resisting engaging in sexual contact when either partner has an open cut or wound in their genitals
- being tested for STIs and asking sexual partners to be tested too
- practicing sexual monogamy
- using extra precautions if youre HIV-positive, as your chance of contracting HCV is much higher if you have HIV
If you have hepatitis C, you should be honest with all sexual partners about your status. This ensures that youre both taking the proper precautions to prevent transmission.
Can You Pass Hepatitis C To A Sex Partner
Sex and Sexuality
Yes, but it is not likely. Compared to hepatitis B virus and the human immunodeficiency virus , it is less likely that you will spread the hepatitis C virus to your sex partner.
If you have one long-term sex partner, and one of you has hepatitis C and one of you does not, you do not need to change your sex habits at all. But, if either you or your partner is worried about the small chance of spreading the hepatitis C virus, you can use latex condoms. This will make it almost impossible to spread the virus. Long-term partners of people with hepatitis C should get tested for the virus. If the test is negative, you will probably not need to repeat it.
If you have more than one sex partner, you are more likely to spread the virus. In this case, reduce the number of sex partners you have, practice safer sex, and always use latex condoms.
There have been outbreaks of sexually transmitted HCV infection among men who have HIV and who have sex with men. It is recommended that men who have sex with men use condoms to reduce the risk of sexually transmitted HCV and other sexually transmitted infections.
Antiviral Medication For Hepatitis C
For people with hepatitis C, the goal of treatment with antiviral medication is to prevent the virus from replicating, or copying itself, and to eliminate the virus from the bloodstream. If the hepatitis C virus has been in the body for more than six months, the infection is considered chronic. Without treatment, most people with acute hepatitis C develop the chronic form of the disease.
Your doctor decides which antiviral medicationor combination of medicationsto prescribe based on the results of a blood test called a genotype test. There are six genotypes, or strains, of the hepatitis C virus, and people with certain genotypes respond more quickly to medical treatment.
For many years, the standard treatment for chronic hepatitis C consisted of the antiviral medications pegylated interferon and ribavirin. Ribavirin is taken by mouth every day, and interferon is an injection that you or a caregiver can administer once a week at home.
In 2013 and 2014, the U.S. Food and Drug Administration approved a group of new medications for the treatment of hepatitis C. These medications, which include sofosbuvir, are very effective and have fewer side effects than older medications, particularly interferon.
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