Thursday, September 29, 2022

Hepatitis B Curable Or Not

Treatment For Chronic Hbv Infection

Clinical trial investigates possibility of stopping medication as cure for Hepatitis B

For chronic HBV infection, antiviral medications are available.

This is not a cure for chronic HBV. However, it can stop the virus from replicating and prevent its progression into advanced liver disease.

A person with a chronic HBV infection can develop cirrhosis or liver cancer rapidly and without warning. If a person does not have access to adequate treatment or facilities, liver cancer can be fatal within months of diagnosis.

People with a chronic HBV infection require ongoing medical evaluation and an ultrasound of the liver

How Is Hepatitis B Treated

Your healthcare provider will treat you based on what type of hepatitis B you have, acute or chronic.

Acute hepatitis B infections

If you develop an acute form of the condition, you probably wont need medical treatment. Instead, your doctor will likely suggest that you get plenty of rest, drink lots of fluids and maintain a healthy diet to support your body as it fights off the infection.

Chronic hepatitis B infections

If you have chronic hepatitis B, you might be a candidate for drug therapy. Usually, drug therapy is used only if you have active liver disease. There are seven drugs that are approved by the U.S. Food and Drug Administration to treat hepatitis B. Two are injectable forms of interferon, while the five other antivirals are tablets.

You will need to take these medications every day. They help by slowing the viruss ability to multiply in your system. This helps reduce swelling and liver damage. Youll need to be regularly monitored for early signs of liver damage and liver cancer. Your healthcare provider will want to see you once or twice a year.

How Do You Get Hepatitis C

Just like hepatitis B, you can get this type by sharing needles or having contact with infected blood. You can also catch it by having sex with somebody who’s infected, but that’s less common.

If you had a blood transfusion before new screening rules were put in place in 1992, you are at risk for hepatitis C. If not, the blood used in transfusions today is safe. It gets checked beforehand to make sure it’s free of the virus that causes hepatitis B and C.

It’s rare, but if you’re pregnant and have the disease, it’s possible to pass it to your newborn.

There are some myths out there about how you get hepatitis C, so let’s set the record straight. It’s not spread by food and water . And you canât spread it by doing any of these things:

  • Joint pain

See your doctor as soon as possible if you have any of these symptoms.

Sometimes, people have no symptoms. To be sure you have hepatitis, youâll need to get tested.

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How Long Does It Last

According to the World Health Organization , the complete vaccine series induces protective antibody levels in of the infants, children, and adolescents who receive it.

Immune memory induced by the HBV vaccine can last for in healthy people. That said, studies into the duration of the protection that the vaccine offers are ongoing.

The Evolution Of Hepatitis C Treatment

Push to cure hepatitis B, a neglected disease

Hepatitis C has been around for a long time. Even before the development of these new treatments, between 15 to 25 percent of individuals infected with HCV did not become chronically infected. Their bodies were able to clear the virus on their own. However, until relatively recently there were few effective treatment options for hepatitis C.

Historically the major treatment regimen was a long course of pegylated interferon and ribavirin. However, these treatments have significant problems. They show an only moderate ability to get rid of the virus and they have significant side effects. For example, one study found that as many as a quarter of people taking interferon developed major depressive episodes due to the treatment regimen.

In addition, those drugs were contraindicated in individuals with advanced liver or kidney disease. That meant that many people with hepatitis C weren’t even eligible to take them.

Interferon and ribavirin were also least effective against the most common types of hepatitis C. Genotype 1 was historically difficult to treat with pegylated interferon and ribavirin. The treatment regimen worked slightly better with genotypes 2 and 3, but those types were also less common.

The combination of poor efficacy and high intolerance were driving forces for the development of interferon-free methods of hepatitis C treatment. These drugs are known as direct acting antivirals . It’s DAAs that have led to hepatitis C being considered curable.

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Treatment For Chronic Infection

Treatment for hepatitis B does not cure hepatitis B but works to delay or even to prevent complications from developing, like liver damage and ‘scarring’ of the liver . People with chronic hepatitis B usually need treatment to stop or to reduce the activity of the virus, so limiting liver damage. A liver specialist will usually advise on when treatment may be beneficial. There are two types of treatment currently given:

  • Interferon. This medicine is similar to a substance produced in your body, which is also called interferon. It works to fight infections by boosting your immune system. Interferon is usually given as an injection each week.
  • Antiviral medicines. These work by stopping the hepatitis B virus from multiplying in the body. They include lamivudine, adefovir, tenofovir, and entecavir. Your doctor will discuss these in more detail with you, as the medicine used can vary between people. A combination of antiviral medicines is sometimes used.

Treatment with medicines is usually continued for many years.

Side-effects with these medicines can occur. You will be monitored regularly while you are taking treatment, which includes blood tests. Some people need to change their medicines, or take a lower strength, if they have troublesome side-effects. Also, in some people, resistance can develop to their treatment medicine, which means that it does not work so well. If this happens then it is likely you will have to change the medicine you take.

Complications Of Hepatitis B

A small proportion of people who become infected with the hepatitis B virus develop a long-term hepatitis B infection. They may have the virus in their bloodstream for most of their life without realising they are infected.

People with chronic hepatitis B infection may not notice any health problems until they develop liver problems such as liver disease or liver cancer later in life. Treatment for hepatitis B is essential because it is not possible to be a healthy carrier of the hepatitis B virus. Chronic hepatitis B infection occurs more commonly in some communities, including:

  • Aboriginal and Torres Strait Islander communities.
  • In people from parts of the world where hepatitis B is more common, such as:
  • North-East Asia
  • Sub-Saharan Africa.

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Hepatitis B And Pregnancy

If youâre pregnant, you might pass the virus to your baby at birth. Itâs less likely to happen during your pregnancy.

If your baby gets the virus and isnât treated, they could have long-term liver problems. All newborns with infected mothers should get hepatitis B immune globulin and the vaccine for hepatitis at birth and during their first year of life.

The Hepatitis B Vaccine

Kill or cure – Hepatitis B

The hepatitis B vaccine is one of the most effective ways to prevent hepatitis B. Its usually divided into three doses, which are given over the course of six months. In many countries, infants receive their first dose of the vaccine at birth.

The Centers for Disease Control recommends that all children under the age of 19 be vaccinated if they havent already received the vaccination. Adults can also get the hepatitis B vaccine, and its generally recommended if you have an increased risk of infection due to:

  • traveling to or living in a region where hepatitis B is common
  • being sexually active with more than one partner
  • working in a medical setting
  • using intravenous drugs

If youve been exposed to the hepatitis B virus and havent been vaccinated, try to see a doctor right away. They can administer the first dose of the vaccine, though youll need to follow up to receive the remaining doses over the next few months.

They can also prescribe a medication called

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How Can I Pay For My Medication

Private health insurance or drug plansIf you have private health insurance or a drug plan at work, you may be able to have the medication paid through your plan. Please consult your private health insurance or drug plan provider to see if your drug is covered.

Publicly funded drug plansEach province and territory has their own rules. Some provincial drug plans provide coverage for individuals 65 and older, or those on social assistance. Some provinces provide special support to low-income individuals. Please call your Provincial Ministry or Department of Health to get more information about the terms of the publicly funded drug plan in your province.

Quebec public drug programIn Quebec, everyone must be covered by prescription drug insurance either through private or publicly funded plans.

Each provincial and territorial government offers a drug benefit plan for eligible groups. Some are income-based universal programs. Most have specific programs for population groups that may require more enhanced coverage for high drug costs. These groups include seniors, recipients of social assistance, and individuals with diseases or conditions that are associated with high drug costs. For more details, please contact your provincial or territorial health care ministry, or click on the appropriate link below.

Yukon

Available Patient Assistance Program for Hepatitis B treatment VEMLIDY

Treatment For Suspected Exposure

Anyone who has had potential exposure to HBV can undergo a postexposure prophylaxis protocol.

This consists of HBV vaccination and hepatitis B immunoglobin . Healthcare workers give the prophylaxis after the exposure and before an acute infection develops.

This protocol will not cure an infection that has already developed. However, it decreases the rate of acute infection.

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Can Hepatitis B Be Prevented Or Avoided

The best way to prevent hepatitis B is to always have protected sex and, if you use intravenous drugs, avoid sharing needles.

A vaccine is available to prevent hepatitis B. It is now routinely given in the first year of life to all newborn infants. It is safe and requires 3 shots over a 6-month period. This vaccine should be given to people who are at high risk for this illness, such as healthcare workers, all children, people who travel to areas where the infection is widespread, drug users, and those who have multiple sex partners.

Hepatitis B Symptoms & Treatment

Hepatitis B cure: Several investigational drugs shoot at ...

FAST FACTS

  • Hepatitis B is a virus found in infected blood, semen and vaginal fluids.
  • Its a sexually transmitted infection that can be passed on through unprotected sex. You can also get it from contaminated needles and syringes. Its also commonly passed on from a mother to her baby during birth.
  • There is a vaccine to prevent hepatitis B, which is routinely offered to infants as well as at-risk groups.
  • You can prevent hepatitis B by practising safer sex, never sharing needles and syringes, and avoiding unlicensed tattoo parlours and acupuncturists.
  • Most people dont need treatment for acute hepatitis B. If the infection becomes chronic, there is no cure, but it can be managed with treatment.

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Hepatitis B During Pregnancy

If a woman with HBV becomes pregnant, they may transmit the virus to their baby. Women should inform the doctor who delivers their baby that they have HBV.

The infant should receive an HBV vaccine and HBIG with 1224 hours of birth. This significantly reduces the risk that they will develop HBV.

The HBV vaccine is safe to receive while pregnant.

People with a high risk of HBV include:

  • the infants of mothers with HBV
  • the sexual partners of people with HBV
  • people who engage in sexual intercourse without contraception and those who have multiple sexual partners
  • men who have sex with men
  • people who inject illicit drugs
  • those who share a household with a person who has a chronic HBV infection
  • healthcare and public safety workers who are at risk of occupational exposure to blood or contaminated bodily fluids
  • people receiving hemodialysis, which is a type of kidney treatment
  • people taking medications that suppress the immune system, such as chemotherapy for cancer
  • those who come from a region with a high incidence of HBV
  • all women during pregnancy

People can prevent HBV infection by:

  • wearing appropriate protective equipment when working in healthcare settings or dealing with medical emergencies
  • not sharing needles
  • following safe sexual practices
  • cleaning any blood spills or dried blood with gloved hands using a 1:10 dilution of one part household bleach to 10 parts water

A vaccine against HBV has been available since 1982.

People who should receive this vaccine include:

How Do I Get Hepatitis B Treatment

Usually for adults, hepatitis B goes away on its own and you wont need treatment. Your doctor might tell you to rest, eat well, and get plenty of fluids. You may also get medicines to help with any symptoms you might have but be sure to talk with your doctor or nurse before taking anything.

If you have chronic hepatitis, there are medicines you can take to treat it. Your doctor will tell you about your options and help you get whatever treatment you need.

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Where Can I Get More Detailed Information On How To Live With Hepatitis B

More detailed information can be found in the Canadian Liver Foundations Healthy Living with Viral Hepatitis booklet, including:

  • What to expect if you have hepatitis B
  • The different types of blood tests and what they measure
  • How to prepare for an appointment with your doctor
  • What choices to make to prevent additional damage to your liver
  • Who needs to know if you have hepatitis B and how to tell them
  • How to recognize and deal with symptoms
  • How to find financial assistance
  • What questions to ask when considering alternative therapies.

What A Hepatitis C Cure Means

If a pregnant women catches Hepatitis C, is it curable? – Dr. Shefali Tyagi

Scientists have a very specific definition of what it means to be cured of hepatitis C. In order to be considered cured, patients must have undetectable HCV RNA on an HCV test 12 or 24 weeks after completing a course of therapy. The lack of detectable HCV is what is known as a sustained virological response .

At first, scientists were reluctant to consider an SVR an actual cure. However, research has shown that when HCV RNA is undetectable in both the blood and the liver, the virus has been cured. In theory, this means it may be possible to eliminate all hepatitis C.

More than 95 percent of hepatitis C patients are theoretically curable by an eight- to 12-week treatment regimen with DAAs.

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Are Alternative Medicines Available

Some people believe certain forms of alternative medicine help cure hepatitis C.

However, the National Center for Complementary and Integrative Health reports that there are no effective, research-proven forms of alternative treatment or complementary medicine for hepatitis C.

Silymarin, also known as milk thistle, is an herb commonly suggested to help cure hepatitis C liver disease. But a rigorous did not find any beneficial effects from this supplement.

What Are The Symptoms

  • Symptoms can take 2 to 6 months to appear.
  • Many people who are infected with hepatitis B have either no symptoms or only mild symptoms.
  • Symptoms of acute hepatitis B can include fatigue, loss of appetite, joint pain, abdominal pain, nausea, vomiting, fever, and dark urine. A small number of people will develop jaundice .
  • Some people develop chronic hepatitis B and most remain contagious for the rest of their lives. Chronic infection may lead to cirrhosis and/or liver cancer. Most people with chronic hepatitis B are unaware of their infection.

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Can A Transplant Cure Hepatitis C

If you develop chronic hepatitis C and it leads to liver cancer or liver failure, you may need a liver transplant. Hepatitis C is one of the most common reasons for a liver transplant.

A liver transplant removes a damaged liver and replaces it with a healthy one. However, theres a high likelihood that the hepatitis C virus will be transmitted to the new liver in time.

The virus lives in your bloodstream, not just your liver. Removing your liver wont cure the disease.

If you have active hepatitis C, continued damage to your new liver is very likely, especially if hepatitis C remains untreated.

Can Hepatitis B Be Controlled By Eating Right And Exercising

Hepatitis B Reactivation with Hepatitis C Treatment

It is important that people with liver disease follow a healthy, nutritious diet as outlined by Health Canada in Eating Well with Canadas Food Guide.

Alcohol can also damage the liver so it is best that people with hepatitis B do not drink. Following a healthy lifestyle may also prevent fatty liver disease, another liver disease highly prevalent in Canada.

However, hepatitis B cannot be controlled by healthy eating and exercise alone. Hepatitis B can only be controlled by currently available treatment as prescribed by your doctor. Your doctor will need to do regular blood tests to know how much of the active virus is in your blood . The viral load test is used to monitor and manage hepatitis B patients. Viral load can tell your doctor if you need treatment for hepatitis B and how well you are responding to treatment.

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