Other Effects On Cellular Signaling
In cancer cells, silybin alters cell cycle regulators and induces apoptosis, both through antioxidant and anti-inflammatory properties and through the inhibition of growth factor receptor-mediated mitogenic and cell survival signaling, particularly related to the activation of tyrosine kinases. PDGF receptor , epidermal growth factor receptor , Bcr-Abl, and KIT are examples of tyrosine kinases overexpressed in most human cancers. Silymarin or silybin are particularly effective in inhibiting EGFR signaling with suppression of cyclin-dependent kinase expression and up regulation of CDK inhibitors . These effects lead to G1 and G2-M arrest in cancer cells, as recently confirmed in a model of human colon cancer. In fact, at a dose ranging from 40-75 mol/L, silybin significantly inhibited cell proliferation through cell cycle arrest via inhibition of cyclin promoter activity.
Because it inhibits constitutive NF-B activation, silybin can induce apoptosis, consistent with a significant decrease in its nuclear level of p65 subunit. In addition, it activates caspase 3 and caspase 9 and decreases survivin levels.
Table summarizes the main cellular signaling affected by silybin.
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What Is Rx Vitamins Hepato Support
Rx Vitamins Hepato Support contains a high quality extract of milk thistle along with antioxidants and supportive nutrients to help promote normal liver function. The active bioflavonoid complex in milk thistle, silymarin, is a powerful antioxidant in the liver and has become the focus of extensive scientific research. The main ingredients in Hepato have been selected as a special formulation to improve the functioning of an unhealthy liver. Milk thistle extract, the main ingredient of Hepato is widely used to help protect liver cells and it promotes proper liver function. Because milk thistle contains silymarin, it prevents glutathione depletion. Hepato is prepared to additionally provide your pet with vitamins that have been identified to help in liver recovery. Vitamin B1 is extremely beneficial to the liver because it helps the body repair itself and can even promote the growth of new liver tissue. Vitamin B12 is used because it helps form red blood cells.
Side Effects From Common Flea And Tick Products
Isoxazoline based products used for prevention and treatment of fleas, ticks, and mites are gaining popularity. Many traditional veterinarians are strongly recommending the use of the isoxazoline class of products. Unfortunately, as the number of animals being given these products has risen, so has the number of pet owners reporting neurological and other adverse reactions.
What side effects are possible when using these drugs?
Neurological side effects or adverse reactions can range from barely noticeable to severe. Adverse reactions to these compounds appear to affect animals randomly, although those with certain chronic diseases, the young and elderly, and animals that are immune-compromised or have the genetic mutation of the MDR1 gene seem to be at higher risk. A survey of pet owners showed that adverse reactions are common.
Some adverse reactions that my clients have seen include:
What should I do if I believe my pet is having an adverse reaction?
Some pet parents have continued these supplements for longer periods of time with no adverse effects if the pet is still experiencing symptoms. If your pet is experiencing seizures, I have additional suggestions.
Report the incident to the FDA and the manufacturer!
How To Use Hepato Support For Your Pets Liver Health
These capsules are intended to be an addition to your petâs heath and functioning by supporting proper liver function and ideal filtration of toxins. For suggested use, give your pet one capsule two times per day, or as recommended from your veterinarian. The dosing of Hepato Support is directed for up to 50 pounds. For every 50 pounds body weight of your pet, consider one capsule. If your pet is over 50 pounds in body weight, two capsules may be necessary for optimal health and support of the liver. As with any care for your pet, it is best to consult with your veterinarian prior to providing Hepato Support for your pet. Safety for your pet is always top priority and your vet should be a primary director of your petâs health.
The liver is one of the most important organs in the body and that is no different for your pets. The liver is responsible for producing most of the compounds your pet’s body needs to support optimal function. The liver is also responsible for filtering toxins from the body and for removing harmful waste from your pet.
Milk thistle has been used by traditional healers for thousands of years to support and promote optimal liver function. Milk thistle supports and promotes optimal liver function in both humans and pets and you can rely on this herb to help promote optimal liver function in your pets.
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Hepato Support 90 C By Rx Vitamins For Pets
Hepato Support 90 C by Rx Vitamins for Pets
Hepato Liver Support For Dogs & Cats 180 Capsules By Rx Vitamins
The health of your pet is important and taking proper measures to keep your pet happy and healthy is important. Just as you do with your body, your pet deserves to take the proper measures to ensure good health and healthy organs. Through proper health, your pet can be a major part of your family for years to come and it starts with the health of your petâs vital organs.
Your pet needs proper support for the organs in order to remain healthy. They have organs just as humans do, which means the organs need to be functioning properly in order to keep a healthy body. Your petâs heart is the control center for pumping blood throughout the body and when the heart functions properly, your pet is happy and energized. Your petâs stomach breaks food down so that digestion can occur and your petâs kidneys help to filter and create urine.
In addition to a healthy heart, stomach, and kidneys, your petâs liver supports life, just as your liver does for you. The liver is responsible for processing blood that travels through the body and filtering the blood to keep it clean and pure. It is capable of metabolizing many different nutrients, detoxifies substances, and even makes clotting proteins for the blood. Just as you would for your health, you will want to ensure your petâs liver health to ensure their health.
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Diseases Of The Gallbladder And Bile Duct
The liver secretes bile, a substance that assists with digestion and absorption of fats and with elimination of certain waste products from the body. Bile is stored in the gallbladder and is released into the small intestine through the bile duct.
Jaundice is often the main sign of diseases of the gallbladder and bile duct. An exception is cancer of the gallbladder, which may not cause jaundice.
Gallbladder agenesis is the lack of a gallbladder from birth. Unless the bile ducts within the liver are also missing, the lack of a gallbladder doesnât cause any problems.
Biliary atresia is the lack of development of bile ducts within the liver and is uncommon. Affected dogs are jaundiced and unthrifty at a young age. The outlook is poor.
Cystic mucosal hyperplasia of the gallbladder is also known as cystic mucinous hypertrophy, cystic mucinous hyperplasia, and mucinous cholecystitis. It is the development and growth of cysts filled with mucusin the gallbladder. It may be caused by treatment with steroid hormones, such as female reproductive hormones. An early stage of the disorder may be a condition known as gallblader dysmotility.
The Use Of Silybin In The Clinical Setting: Efficacy And Suggestions
The use of silymarin in the clinical setting has a long history in its native Mediterranean region, it has been employed for liver damage since the Greco-Roman era. As mentioned in the introduction, herbal therapy use is consistently increasing worldwide, and some of the most common herbal supplement preparations are derived from the milk thistle plant . Despite a long history of its use and the large number of people who consume this substance, no conclusive data on its clinical efficacy can be identified. In fact, only a few well designed clinical trials have been performed. Most studies have been conducted using silymarin and with inclusion of patients with alcoholic or viral cirrhosis. Stickel et al identified the 10 main controlled trials conducted in liver patients, with numbers of patients ranging from 20 to 200 and doses of silymarin ranging from 210 to 450 mg/d for 7 to 730 d. These clinical studies generally have suffered from the same shortcomings found in many other trials on herbal medicines, such as a small sample size, lack of appropriate randomization and of allocation concealment or blinding, very different periods of treatment, lack of information about type and dose of extract used as well as product characterization, ill-defined patient population, and a lack of etiology, severity of disease, and discussion of potential confounders.
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Functions Of The Liver
Prescribed supplements may include B vitamins, vitamin K, and vitamin E. Low potassium levels and decreased levels of B vitamins are common complications with liver disease, and supplementation is often recommended. Vitamin C does not appear to become depleted in dogs with liver disease, and supplementation is not recommended in dogs with copper storage liver disease. Injections of vitamin K are sometimes given to dogs with bleeding tendencies. Follow your veterinarianâs recommendations on vitamin supplementation because overdoses of some vitamins can be harmful.
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Disorders Of The Liver And Gallbladder In Dogs
, BS, DVM, DACVIM, Department of Clinical Sciences, College of Veterinary Medicine, Cornell University
The liver is an organ that performs numerous functions. It has a large storage capacity and functional reserve and is capable of regenerating. These properties provide some protection against permanent damage. However, the liver is also susceptible to injury because of its role in metabolizing, detoxifying, and storing various toxic compounds.
Signs that a dog has liver disease can vary and include loss of appetite, vomiting, stomach ulceration, diarrhea, seizures or other neurologic problems, fever, blood clotting problems, jaundice , fluid collection in the abdomen, excessive urination and thirst, changes in liver size, and weight loss. Gastrointestinal bleeding can be seen in animals with liver disease due to ulcers or problems with blood clotting. The veterinarians understanding of the potential causes of each of these signs helps him or her to diagnose illness and provide appropriate treatment.
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Rupture Of The Gallbladder Or Bile Duct
Rupture of the gallbladder or bile duct is most often due to gallstone obstruction, inflammation of the gallbladder, or blunt trauma. Rupture of the bile duct may also occur as a result of cancer or certain parasites. Rupture leads to leakage of bile into the abdomen, causing a serious condition called bile peritonitis, which may be fatal if the rupture is not repaired. Treatment includes surgery, which consists of placing a stent in the bile duct, removing the gallbladder, or connecting the gallbladder with the small intestine.
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Hepato Trubenefitstm Vs The Leading Liver Supplements
Other liver supplements contain SAMe, an expensive, difficult to manufacture, unstable ingredient. SAMe products cant be given with food, which can be difficult for pets. Hepato TruBenefitsTM uses Glutathione, an antioxidant that can be given with food. The result is a less expensive product that is easier for your pet to take.
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A Good Diet Includes Dog Supplements For Liver Disease
There is no specific diet that fits for all dogs, but there are a few Dog Supplements For Liver Disease that are recommended. The goal of any dietary treatments is four-part:
When it comes to good nutrition for energy, protein is typically what your pet needs. However, for dogs with liver disease, the amount of protein they should take in can vary. Some stages will require more protein, some stages will recommend less. When protein is limited, many vets will suggest dairy, soy, and eggs rather than meat sources.
Effectiveness Of The Hepato Support Supplement In Liver Disease
A new clinical study of dogs with elevated liver enzymes has verified the beneficial results seen in practice with Hepato Support from Rx Vitamins. Numerous studies in laboratory animals and humans have repeatedly demonstrated that the antioxidant silymarin can benefit the liver. Silymarin use in liver diseases has been documented in herbal texts since the 16th century. Very few studies however, demonstrate the usefulness of milk thistle in the veterinary patient.
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Silymarin Has Been Found To Possess The Following Attributes That Are Useful In Veterinary Medicine:
1. Antioxidant scavenges ROS and protects against glutathione depletion2. Inhibits hepatocyte membrane lipid peroxidation 3. Antifibrotic5. Increases hepatic protein synthesis6. Increases rate of hepatocyte regeneration7. Choleretic thins the bile, stimulates contraction of gall bladder8. Protects DNA by reducing lipoxygenase, hydrogen peroxide, and superoxide radicals9. Suppresses transcription factor -kappaB10. Chelates iron which helps to spare glutathione with iron overload11. Stabilizes mast cells 12. Slows calcium metabolism 13. Decreases activity of promoters of cancer growth.
Hepato Support, contains silymarin complexed with hepatotrophic nutraceuticals to facilitate normalization of liver function. The addition of these nutrients improves the efficacy of the silymarin alone by supporting the metabolic, antioxidant, and detoxification functions of the liver.
This study can be read in its entirety by clicking here.
Purchase Hepato Support from Rx Vitamins.
NB: It is important for my clients to understand that nutraceutical support of this type only addresses the physiologic piece of the liver diease puzzle. Hepato Support and similar supplements are wonderful for supporting the body while it heals naturally. The healing process itself is best addressed using gentle energetic homeopathic stimulation.Dr. Jeff
Symptoms Of Hepatic Failure In Dogs
There are a variety of symptoms of hepatic failure that can be seen in your dog. The first signs that are typically seen in hepatic failure are:
More severe symptoms may constitute an emergency requiring immediate attention. These include:
- Excessive thirst
Hepatic failure may happen suddenly or develop slowly. Acute hepatic failure can occur in conjunction with any condition that affects the liver for example, hepatic failure can be caused by poisoning if the toxins taken in by your dog are more than what his liver is able to handle. Hepatic failure can also occur as a result of long term, chronic liver disease where the disease progresses slowly, but over time your dog will develop symptoms of hepatic failure.
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What Side Effects Can Corticosteroids Cause
Corticosteroids may have both short- and long-term side effects that cause different problems in your dog.
Short-term side effects
Short-term side effects are those that we expect a dog to experience when initially placed on corticosteroids. These side effects depend both on the type of steroid prescribed and on the dosage administered, and include:
- increased thirst and urination
- development or worsening of infections
- vomiting or nausea
Some pre-diabetic dogs may become diabetic with corticosteroid usage. In many of these cases, the diabetes resolves once the steroid is discontinued.
If any of these side effects occur, they can often be eliminated by lowering the dosage or frequency of administration. In some cases, your veterinarian may prescribe another type of corticosteroid in an attempt to reduce the side effects. The objective is to determine the lowest dose of medication that controls the condition with the least number of side effects.
Long-term side effects
Some diseases and medical conditions require long-term treatment with corticosteroids, at either an anti-inflammatory dose or an immunosuppressive dose. When corticosteroids will be used for more than three to four months, particularly at immunosuppressive doses, additional side effects become a concern. The most commonly seen long-term side effects include:
Side Effects Of Zentonil
While Zentonil is considered safe for use, some pets may show signs of vomiting. If the vomiting lasts for more than a day, you must seek medical care. Besides this, the supplement may have certain drug interactions when combined with a few medications or over the counter drugs. To prevent this from happening you must keep your vet informed about all other medications that you are giving your pet even if theyre herbal remedies or homeopathic preparations.
Since Zentonil is nutrient supplement and not a medication, it doesnt have to undergo strict testing. Therefore the product may not have standardized production. Its thus best to buy it from the vet to protect your dogs health.
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