Symptoms Of Acute Viral Hepatitis
Acute viral hepatitis can cause anything from a minor flu-like illness to fatal liver failure Liver Failure Liver failure is severe deterioration in liver function. Liver failure is caused by a disorder or substance that damages the liver. Most people have jaundice , feel tired… read more . Sometimes there are no symptoms. The severity of symptoms and speed of recovery vary considerably, depending on the particular virus and on the person’s response to the infection. Hepatitis A and C often cause very mild symptoms or none at all and may be unnoticed. Hepatitis B and E are more likely to produce severe symptoms. Infection with both hepatitis B and D may make the symptoms of hepatitis B even more severe.
Symptoms of acute viral hepatitis usually begin suddenly. They include
A poor appetite
A general feeling of illness
Nausea and vomiting
Pain in the upper right part of the abdomen
In people who smoke, a distaste for cigarettes is a typical symptom. Occasionally, especially with hepatitis B, infected people develop joint pains and itchy red hives on the skin from mast cells in the skin, which cause fluid to leak out of small… read more ).
Appetite usually returns about a week after symptoms begin.
People with acute viral hepatitis usually recover in 4 to 8 weeks, even without treatment. However, some people infected with hepatitis B or C develop chronic infections.
Research And Statistics: Who Has Hepatitis C How Many People Have Hepatitis C
Health officials reported 2,967 cases of acute hepatitis C in 2016, but the CDC estimates that the actual number of acute cases is 13.9 times the number of reported cases in any year. The CDC put the real number of acute hepatitis C cases in 2016 at an estimated 41,200.
Despite these estimates, we really do not know how many people are infected with HCV, Dr. Branch says, adding that the U.S. estimates come from specific datasets that do not include prisoners or the homeless and have too small a sample size to yield precise data.
The Journal of Infectious Diseases
Its unclear how many people fail to get treatment in time and die from HCV-related issues. According to the CDC, there were 18,153 reported deaths related to HCV, but this is likely an underestimate.
HCV may be causing 3 to 5 times more deaths than we know, Branch says. Better information about the number of HCV-related deaths would help make HCV testing and treatment more of a priority.
What Is Hepatitis E
Hepatitis E, also called enteric hepatitis , is similar to hepatitis A, and more prevalent in Asia and Africa. It is also transmitted through the fecal-oral route. It is generally not fatal, though it is more serious in women during pregnancy and can cause fetal complications. Most patients with hepatitis E recover completely.
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Who Is At Risk For Infection
Anyone who is not immune to hepatitis A can get hepatitis A infection. Food-borne outbreaks occur sporadically throughout the USA. Certain groups of people do have a higher risk of developing HAV infection and should be vaccinated:
- Persons experiencing homelessness
- People who eat raw or under-cooked shellfish
Can I Breastfeed My Baby If I Have Viral Hepatitis
Yes, you can breastfeed your baby if you have viral hepatitis. You cannot pass viral hepatitis through breastmilk.
But, if you have hepatitis C and your nipple or the surrounding skin is cracked or bleeding, stop nursing your baby on that breast until the sores heal. You can pump or hand-express your milk from that breast until it heals. Throw any breastmilk from that breast away, because it might have been contaminated with hepatitis C from the cracked or bleeding skin.
Pumping the breast that is cracked or bleeding will help keep up your milk supply and prevent the breast from getting overly full and painful. You can feed your baby your milk from your healthy breast.
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Hepatitis B: How Does It Spread
You can get it through contact with the blood or body fluids of an infected person. In the U.S., it’s most often spread through unprotected sex. It’s also possible to get hepatitis B by sharing an infected person’s needles, razors, or toothbrush. And an infected mother can pass the virus to their baby during childbirth. Hepatitis B is not spread by hugging, sharing food, or coughing.
Treatment For Hepatitis A
There is no specific treatment for hepatitis A. In most cases, your immune system will clear the infection and your liver will completely heal. Treatment aims to ease symptoms and reduce the risk of complications. Options may include:
- Rest hepatitis A can make you tired and lacking in energy for day-to-day life, so rest when you can.
- Eat small meals more often nausea can affect your ability to eat and can contribute to tiredness, so eat small amounts of high-calorie foods often if nausea is a problem.
- Protect your liver the liver processes medication and alcohol, so avoid alcohol and review any medication with your doctor.
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Who Should Get The Hepatitis A Vaccine
The Advisory Committee on Immunization Practices recommends that all children in the U.S. get vaccinated against hepatitis A at age 12 months. However, if an infant aged 6-11 months will be traveling to a country with a significant number of people with hepatitis A, the child should get one dose before leaving the U.S. The child should then get 2 doses separated by 6 to 18 months when the child is between 12 months and 23 months.
You should also get the hepatitis A vaccine if you fall into one of the following groups:
- Men who have sexual contact with other men.
- Users of any type of illegal drugs.
- People with blood clot disorders, such as hemophilia.
- People who have chronic liver disease.
- Homeless people.
- People who will be closely involved with a person being adopted from a country with high rates of hepatitis A infections.
If I Have Hepatitis B And Feel Healthy Do I Need To Keep Going To My Doctor
Chronic hepatitis B is a silent disease because often no symptoms appear until your liver is severely damaged. Although many people with chronic hepatitis B have an inactive disease and will remain healthy, about one in four will have an active disease that may lead to cirrhosis, liver failure, and liver cancer.
Because hepatitis B has no symptoms until your liver is badly damaged, a blood test is the only way for your doctor to find out if your hepatitis B is active or inactive, and to offer treatment, if needed. To help your doctor monitor how your disease behaves over time, you will need lifelong repeat blood tests every six to 12 months. Some tests, such as HBV DNA may need to be done more frequently . No treatment is required while the virus is inactive, but you should continue to get regular blood tests from your doctor to monitor your liver disease.
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How Is Hepatitis B Diagnosed
A diagnosis of hepatitis B infection is made using blood tests.
Because many people do not have symptoms when they get hepatitis B, they may never be diagnosed. Thats why screening for hepatitis B is recommended in a number of people including:
- people at higher risk
If you think you have been exposed to infected blood or body fluids, see a doctor as soon as possible. There are treatments that can reduce your risk of developing the infection, if given shortly after exposure.
How Do You Get Hepatitis A
Hepatitis A can be spread by sexual contact with an infected person or close personal contact . However, it is most often spread by what scientists call the fecal-oral route. This happens when one person eats or drinks something that has small amounts of fecal matter from another person who has hepatitis A. This can happen by touching something that has the virus on it and then putting your hands in your mouth. It can happen when food is grown, picked, processed or served. Water can also be contaminated.
Mothers do not pass on hepatitis A in breast milk. You cannot be infected with HAV by sitting near to or hugging someone with hepatitis A. It does not spread through coughs or sneezes.
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Treatment: Chronic Hepatitis C
The latest drug to be approved by the FDA is glecaprevir and pibrentasvir . This medication offers a shorter treatment cycle of 8 weeks for adult patients with all types of HCV who donât have cirrhosis and who have not been previously treated. The length of treatment is longer for those who are in a different disease stage. The prescribed dosage for this medicine is 3 tablets daily.
There are several other combination drugs available, as well as some single drugs that may be used in combination. Your doctor will choose the right one for you depending on the type of hepatitis C you have, how well your liver is functioning and any other medical problems you may have. Also be sure to discuss your insurance coverage since these medications are expensive.
How Can You Prevent Hepatitis A
There is a vaccine, made from an inactivateddeadvirus to prevent hepatitis A. If you are not sure you have had the vaccine, you can ask your doctor to test you to see if you have been vaccinated.
You can also practice good hand washing hygiene. Make sure you use soap and warm water to wash your hands for at least 15 to 30 seconds after you use the toilet, change diapers, and before and after touching food.
If you are traveling in another country, especially a developing country, drink only bottled water and use only bottled water to brush your teeth, wash your produce, and freeze for ice cubes.
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How Is Viral Hepatitis Diagnosed
Diagnosis of viral hepatitis is based on symptoms and physical findings as well as blood tests for liver enzymes, viral antibodies, and viral genetic materials.
Symptoms and physical findings
Diagnosis of acute viral hepatitis often is easy, but the diagnosis of chronic hepatitis can be difficult. When a patient reports symptoms of fatigue, nausea, abdominal pain, darkening of urine, and then develops jaundice, the diagnosis of acute viral hepatitis is likely and can be confirmed by blood tests. On the other hand, patients with chronic hepatitis due to HBV and HCV often have no symptoms or only mild nonspecific symptoms such as chronic fatigue. Typically, these patients do not have jaundice until the liver damage is far advanced. Therefore, these patients can remain undiagnosed for years to decades.
There are three types of blood tests for evaluating patients with hepatitis: liver enzymes, antibodies to the hepatitis viruses, and viral proteins or genetic material .
Liver enzymes: Among the most sensitive and widely used blood tests for evaluating patients with hepatitis are liver enzymes, called aminotransferases. They include aspartate aminotransferase and alanine aminotransferase . These enzymes normally are contained within liver cells. If the liver is injured , the liver cells spill the enzymes into the blood, raising the enzyme levels in the blood and signaling that the liver is damaged.
Examples of tests for viral antibodies are:
How Long Does It Last
Hepatitis A can last from a few weeks to several months.
Hepatitis B can range from a mild illness, lasting a few weeks, to a serious, life-long condition. More than 90% of unimmunized infants who get infected develop a chronic infection, but 6%10% of older children and adults who get infected develop chronic hepatitis B.
Hepatitis C can range from a mild illness, lasting a few weeks, to a serious, life-long infection. Most people who get infected with the hepatitis C virus develop chronic hepatitis C.
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Common Examples Of How Hepatitis A Is Spread
The hepatitis A virus usually spreads from person to person contact or from contaminated food or water. According to the Centers for Disease Control and Prevention, here are common examples:
- When an infected person touches objects or food after using the toilet without proper handwashing
- When changing the diaper of someone infected but not washing hands afterward
Treatment: Chronic Hepatitis B
The goal of treating chronic hepatitis B is to control the virus and keep it from damaging the liver. This begins with regular monitoring for signs of liver disease. Antiviral medications may help, but not everyone can take them or needs to be on medication. Be sure to discuss the risks and benefits of antiviral therapy with your doctor.
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What If I Am Pregnant
It’s recommended that all pregnant women have a blood test for hepatitis B in early pregnancy.
If you have hepatitis B and are pregnant, treatments can reduce the risk of transmission of hepatitis B to the baby.
If you have hepatitis B, it is important to protect others from infection.
Important ways to prevent the spread of hepatitis B include:
- vaccination of all your close contacts
- practise safe sex until your sexual contacts are fully vaccinated and immune
- do not donate blood, organs or body tissue
- do not allow your blood to contact another person
- inform healthcare workers
- if your work involves potential for your blood or other body fluid to spread to other people, discuss your situation with your doctor
The hepatitis B vaccine is safe and effective in protecting against hepatitis B infection, providing protection in 95 in 100 vaccinated people.
In Australia, hepatitis B vaccination is part of the standard immunisation schedule for all newborn babies and infants. It’s also recommended for adults who are at high risk of exposure, people who are immunosuppressed or have other liver disease. People in these risk groups should be vaccinated against hepatitis B. Talk to your doctor about your level of risk and whether hepatitis B vaccination is recommended for you.
If you werent vaccinated against hepatitis B as a child, or if youre not sure whether you are vaccinated, talk to your doctor about whether you need a catch-up vaccine.
How Can I Tell If I Have The Disease
If you have hepatitis A you might get a sudden fever or headache and feel tired. You might not want to eat as much as usual, and you may feel queasy. You may vomit or have stomach pain. Some people with the disease have chills, aching muscles and joints, cough, diarrhea, constipation, or itchy skin.
Later in the disease you may have jaundice , and your feces may be pale or clay colored. Rarely, the brain can be affected. This can cause confusion, unusual eye and body movements, and even coma.
Your doctor can do a blood test to see if you have the disease. Other things your doctor may look for are a painful and large liver, spleen, or lymph nodes, and a slow heart rate.
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Questions To Ask Your Doctor
- Do I need treatment?
- What treatment is best for me?
- What medicines should I take?
- Are there any medicines I should avoid?
- How can I cope with the side effects of treatment?
- Is there a therapist I can talk to?
- How long will my treatment last?
- Can hepatitis C be cured?
- Are organ transplants and blood transfusions safe?
- Is it safe for me to get pregnant?
What Are The Symptoms Of Hepatitis A
Children who become infected with hepatitis A before age 6 usually have no symptoms or mild illness, and if they do become ill, they usually get better in under 2 months. Adults and older children who become infected with hepatitis A can have no symptoms or very mild illness , but most develop jaundice and other symptoms . Mild illness can resolve in 1-2 weeks, but more severe illness can last for months. Common symptoms of HAV infection include:
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What Are The Complications Of Hepatitis B
The course of hepatitis B infection depends mostly on the age at which a person is infected.
People infected as infants are likely to develop long term infection and can get complications such as scarring of the liver or liver cancer. Infants have a 9 in 10 chance and children have a 3 in 10 chance of developing a chronic, lifelong infection.
People infected as teenagers or adults are likely to become unwell with symptoms , but have a smaller chance of developing a chronic infection. Others develop a silent infection, without any symptoms.
Most people infected as adults clear the virus from the body within 6 months. They develop immunity to future hepatitis B infections and do not develop long-term liver damage.
However, approximately 1 in 20 adults cannot clear the virus and develop chronic hepatitis B. They are at risk of developing complications such as cirrhosis and liver cancer in the longer term.
Hcv Originated At Least 3000 Years Ago
Previous studies provided estimates of the time to the most recent common ancestor of HCV genotypes in a range between 200 and 1000 years ago, with one single study indicating that HCV origin may date 2000 years back . The tMRCA of equine/canine hepaciviruses was estimated to be recent, dating around 1800 CE .
It is well known that the temporal variation in rates of nucleotide substitutions often results in underestimation of the age of viral lineages . Purifying selection and substitution saturation are strongly associated with temporal rate variation .
Simulations experiments indicated that classic models tend to underestimate branch lengths in the presence of purifying selection and substitution saturation . Because both phenomena are more pronounced for internal branches, length underestimation is more severe for these branches and dating inferences are consequently affected . The use of models that allow site- and branch-specific variation in selective pressure can improve branch length estimates in the presence of both purifying selection and substitution saturation .
FIGURE 2. tMRCA estimation. Comparison of branch lengths obtained using the aBS-REL and the GTR models for the NS5B abd EHV phylogenies. Timescaled phylogenetic tree estimated for 67 HCV subtypes. The scale bar below the phylogeny represents years before present. The tMRCAs of analyzed nodes are reported in red with 95% confidence intervals. Geographic distribution of HCV endemic transmissions .
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