How Is Hepatitis B Diagnosed
There are three main ways to diagnose HBV infection. They include:
- Blood tests: Tests of the blood serum shows how your bodys immune system is responding to the virus. A blood test can also tell you if you are immune to HBV.
- Abdominal ultrasound: An ultrasound uses sound waves to show the size and shape of your liver and how well the blood flows through it.
- Liver biopsy: A small sample of your liver tissue is removed though a tiny incision and sent to a lab for analysis.
The blood test that is used to diagnose hepatitis B is not a test that you get routinely during a medical visit. Often, people whove become infected first learn they have hepatitis B when they go to donate blood. Blood donations are routinely scanned for the infection.
The virus can be detected within 30 to 60 days of infection. About 70% of adults with hepatitis B develop symptoms, which tend to appear an average of 90 days after initial exposure to the virus.
Treatment Of Hepatitis C
Hepatitis C is treated with antiviral medications that aim to clear the virus from your body.
New all-tablet treatments have greatly improved the outcomes for people with hepatitis C. These treatments can cure more than 95% of individuals with chronic hepatitis C. There are several new tablets that are used in combination to treat all hepatitis C strains . They are effective for people with no liver damage and those who have more advanced liver damage or cirrhosis.
These new tablet medications are available and subsidised on the Pharmaceutical Benefits Scheme, and can be prescribed by specialists, general practitioners and specialised nurse practitioners.
There are no restrictions on accessing treatment it is available for all adults with a Medicare card. People under 18 are able to access treatment and it is recommended they are referred to a pediatrician experienced in the treatment of hepatitis C.
For more information on the new medications for the treatment of hepatitis C, see our video: Hepatitis C Cure what it means for Victorians.
If your doctor does not know about the new treatments, you can call the LiverLine on for information, and to find a GP who can help you.
Talk with your doctor about treatment options and the potential for interactions with other medications, herbal preparations and other drugs. If you take prescribed medication this will be managed so you can access treatment.
In general, if you have hepatitis C you will feel better if you:
Life Expectancy And Prognosis
Can you die from hepatitis? Technically, the complications of chronic hepatitis C are fatal. About 30,000 people in the U.S. die each year from cirrhosis.
How long can you live with untreated hep C? The disease affects everyone differently, so thereâs no rule. But about 70% to 80% of people with will get chronic help C. Within 20 years, about 20% to 30% of those people will get cirrhosis. From there, it depends on what type of cirrhosis you have, your treatment, and if you can get a liver transplant.
Can hepatitis C go away on its own? Yes. From 15% to 20% of people with hep C clear it from their bodies without treatment. Itâs more likely to happen in women and people who have symptoms. But it usually happens between 4 and 18 months after symptoms start.
American Liver Foundation Hep C 123: âFrequently Asked Questions.â
Gastroenterology: âExtrahepatic morbidity and mortality of chronic hepatitis C.â
National Institute of Diabetes and Digestive and Kidney Diseases: âHepatitis C.â
Therapeutic Advances in Infectious Disease: âExtrahepatic Manifestations of Chronic Hepatitis C Virus Infection.â
The Hepatitis C Support Project: âAn Overview of Extrahepatic Manifestations of Hepatitis C.â
BioDrugs: âManagement of hepatitis C virus-related arthritis.â
Frontiers in Endocrinology: âDiabetes and Hepatitis C: A Two-Way Association.â
U.S. National Library of Medicine: âAtherosclerosis,â âPreventing Hepatitis B or C.â
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What Should You Know About Pregnancy And Hepatitis B
A pregnant woman who has hepatitis B can pass the infection to her baby at delivery. This is true for both vaginal and cesarean deliveries.
You should ask your healthcare provider to test you for hepatitis B when you find out you are pregnant. However, while it is important for you and your healthcare provider to know if you do have hepatitis B, the condition should not affect the way that your pregnancy progresses.
If you do test positive, your provider may suggest that you contact another healthcare provider, a liver doctor, who is skilled in managing people with hepatitis B infections. You may have a high viral load and may need treatment during the last 3 months of your pregnancy. A viral load is the term for how much of the infection you have inside of you.
You can prevent your infant from getting hepatitis B infection by making sure that your baby gets the hepatitis B vaccine in the hours after they are born along with the hepatitis B immunoglobulin. These two shots are given in two different locations on the baby. They are the first shots needed.
Depending on the type of vaccine used, two or three more doses must be given, usually when the baby is 1 month old and then 6 months old, with the last by the time the baby is 1 year old. It is critical that all newborns get the hepatitis B vaccination, but even more important if you have hepatitis B yourself.
Nonvirological Theories Of Hcv
In contrast to the seven positive studies cited in , the remaining negative study found that HCV+ patients performed no differently than HCVâ controls only HCV+ patients with decompensated cirrhosis evidenced worse performance . Although reasons for this incongruent finding remain unclear, its sample contrasted with other studies in terms of its low proportion of subjects with a history of intravenous drug use and its careful exclusion of patients with currently symptomatic medical comorbidities. This, of course, raises the possibility that HCV-associated cognitive impairment may be related to medical or substance use history rather than HCV itself. Indeed, an earlier study compared 66 HCV+ patients to 14 HCVâ controls with other types of liver disease on measures of cognitive functioning . Only the subgroup of HCV+ patients with medical comorbidities exhibited cognitive impairment, while the HCV+ patients with no medical comorbidities did not differ from HCVâ controls. While this study suggests that, for patients without medical comorbidities, the severity of HCV-associated cognitive impairment may not exceed the impairment level known to be associated with other types of liver disease , it remains unclear how the HCV+ patients may have compared to HCVâ controls without liver disease.
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Diagnosis Of Hcv Infection
Diagnosis of HCV infection was made by serological testing , PCR or both. Genotyping of HCV has been performed according to the centers local routines and reported if available.
Follow-up and antiviral therapy
Patients were followed according to each participating center’s normal routines and neither protocol-specific sampling nor diagnostic procedure was performed. Antiviral therapy was given according to each center’s routines and varied over time. Chronic GVHD was scored as reported by the investigators and biopsy confirmation was not required.
Complications Of Hepatitis C
If the infection is left untreated for many years, some people with hepatitis C will develop scarring of the liver .
Over time, this can cause the liver to stop working properly.
In severe cases, life-threatening problems, such as liver failure, where the liver loses most or all of its functions, or liver cancer, can eventually develop.
Treating hepatitis C as early as possible can help reduce the risk of these problems happening.
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Tests To Diagnose Hepatitis C
How is Hepatitis C diagnosed?
There are two main blood tests typically used to diagnose Hepatitis C. First, youll have a screening test that shows if youve ever had Hepatitis C at some point in your life. If this test is positive, youll have a second test to see if you have Hepatitis C now. These blood tests are described below:
Hepatitis C antibody test
This is the screening test used by doctors to show whether or not you have ever been exposed to Hepatitis C at some time in your life, by detecting antibodies in your blood. Antibodies are substances your body makes to fight off all kinds of infections. If you were ever infected with Hepatitis C, your body would have made antibodies to fight the virus.
If the test result is:
- Negative, it means you have not been exposed to Hepatitis C and further testing is usually not needed.
- Positive, you have had Hepatitis C at some point. However, it does not tell you whether you have it now. Youll need to see your doctor for another test the Hepatitis C RNA test to determine if the virus is still active and present in your blood.
Hepatitis C RNA Qualitative Test
This test will determine whether or not you are currently infected with Hepatitis C. It is often called the PCR test because of the process used . It looks for the genetic material of the Hepatitis C virus in your blood.
If the test result is:
Hepatitis C RNA Quantitative Test
Causes Of Hepatitis C
You can become infected with hepatitis C if you come into contact with the blood of an infected person.
Other bodily fluids can also contain the virus, but blood contains the highest level of it. Just a small trace of blood can cause an infection. At room temperature, it’s thought the virus may be able survive outside the body in patches of dried blood on surfaces for up to several weeks.
The main ways you can become infected with the hepatitis C virus are described below.
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Treating Hepatitis C Matters
When you see your doctor and start treatment for a chronic hep C infection, you can prevent these problems, improve them, or keep them from getting worse. New drugs can clear the virus from your body in a few months with fewer side effects than older medicines. If thereâs no virus in your blood 3 months after treatment, youâre considered cured.
Getting rid of the infection protects others, too. Hepatitis C spreads through blood-to-blood contact. You could infect a loved one if you accidentally use their toothbrush or cut yourself and donât clean up the blood properly. People who get hep C treatment greatly lower the odds that they will pass the virus to someone else.
If you arenât sure if you have hepatitis C, talk to your doctor to see if you should get tested. Learn why you should get tested for hepatitis C.
When To Seek Medical Advice
See your GP if you persistently have any of the later symptoms above, or if they keep returning. They may recommend having a blood test that can check for hepatitis C. Read more about diagnosing hepatitis C.
None of the symptoms above mean you definitely have hepatitis C, but it’s important to get them checked out.
You should also speak to your GP about getting tested if there’s a risk you’re infected, even if you don’t have any symptoms. This particularly includes people who inject drugs or have done so in the past.
Read about the causes of hepatitis C for more information about who’s at risk of having the infection.
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What The Cdc Recommends
Were you born between 1945 and 1965? If so, then youre a member of the Hepatitis C generation. The CDC recently recommended that all people born between during this time have a 1-time screening test for Hepatitis C. We now have new drugs that can treat and cure Hepatitis C so you should go get tested today.
The life you save may be your own! Please contact your local healthcare provider.
Who Should Be Vaccinated For Hepatitis B
All newborns should be vaccinated. Also, people who are under 18 who were not vaccinated at birth should also get the vaccine. Other groups who should be sure to be vaccinated are those in certain high-risk categories, such as:
- People who have more than one sexual partner.
- Men who have sex with men.
- Adults with diabetes.
- Sexual partners of infected people and people who share households with infected individuals.
- People who are exposed to blood and other bodily fluids, including healthcare and public safety professionals, and people who work in jails and other places taking care of people who cant take care of themselves.
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How Do Doctors Treat Hepatitis C
Doctors treat hepatitis C with antiviral medicines that attack the virus and can cure the disease in most cases.
Several newer medicines, called direct-acting antiviral medicines, have been approved to treat hepatitis C since 2013. Studies show that these medicines can cure chronic hepatitis C in most people with this disease. These medicines can also cure acute hepatitis C. In some cases, doctors recommend waiting to see if an acute infection becomes chronic before starting treatment.
Your doctor may prescribe one or more of these newer, direct-acting antiviral medicines to treat hepatitis C:
You may need to take medicines for 8 to 24 weeks to cure hepatitis C. Your doctor will prescribe medicines and recommend a length of treatment based on
- which hepatitis C genotype you have
- how much liver damage you have
- whether you have been treated for hepatitis C in the past
Your doctor may order blood tests during and after your treatment. Blood tests can show whether the treatment is working. Hepatitis C medicines cure the infection in most people who complete treatment.
Hepatitis C medicines may cause side effects. Talk with your doctor about the side effects of treatment. Check with your doctor before taking any other prescription or over-the-counter medicines.
The Effects Of Hepatitis C On Your Body
You may have seen numerous literature and commercials about chronic hepatitis C and for good reason. According to the Centers for Disease Control and Prevention , up to 3.9 million people in the United States may have the chronic form of this virus. According to the World Health Organization , over 70 million people are affected worldwide.
What exactly is chronic HCV? In a nutshell, it refers to ongoing inflammation of your liver. But it can lead to symptoms throughout your body. Over time, living with this condition can cause your body to be especially vulnerable to serious health complications.
HCV is transmitted through contact with the blood. Its rarely transmitted through sexual contact from someone infected with the virus. Ultimately, this infection leads to liver inflammation and a host of other issues that can severely damage your health.
The virus has two stages, acute and chronic. The acute stage happens within six months of being exposed to the virus. For some, this is a short-term illness. But according to the CDC, most people about 75 to 80 percent will develop chronic HCV. This means it can be lifelong. Most people dont realize they have the virus until other symptoms within their body start.
Although the hepatitis A, B, and C viruses all cause hepatitis, they are three different and distinct viruses.
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How Will I Know If My Treatment Works
The goal of treatment is to reduce the amount of the hepatitis C virus in your blood to levels that cant be detected after 24 weeks of therapy. The amount of the virus in your blood is called your viral load. At the end of your treatment, your doctor will need to measure your viral load and find out how healthy your liver is. He or she may repeat many of the same tests that were done when you were first diagnosed with hepatitis C.
If your blood has so few copies of the virus that tests cant measure them, the virus is said to be undetectable. If it stays undetectable for at least 6 months after your treatment is finished, you have what is called a sustained virologic response . People who have an SVR have a good chance of avoiding serious liver problems in the future.
Treatment may not reduce your viral load. You may not have an SVR after treatment. If thats true, your doctor will discuss other treatment options with you. For example, if 1 round of treatment did not decrease your viral load enough, your doctor may recommend a second round. Even if treatment doesnt keep you from having active liver disease, lowering your viral load and controlling chronic liver inflammation may help you feel better for a longer time.
Report Raises Questions About Long
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Researchers raised questions about the long-term safety of direct-acting antivirals for hepatitis C virus infection after an analysis of FDA data uncovered more than 500 reports of liver failure and more than 1,000 reports of severe liver injury related to the drugs over one recent 12-month period.
According to the authors of QuarterWatch, an independent publication of the nonprofit Institute for Safe Medication Practices , the FDA also received more than 700 reports of antiviral failure related to the drugs during the same time span.
Last October, the FDA announced that it would require certain DAAs to carry a box warning its most prominent warning after identifying 24 patients who experienced a recurrence of hepatitis B virus infection while being treated for HCV. Recurring HBV infection can potentially cause serious liver problems and death.
Thomas J. Moore, senior scientist for drug safety and policy at ISMP, and colleagues said they looked beyond the cases cited by the FDA to review the most recent data in the FDAs Adverse Event Reporting System, also known as MedWatch reports.
Moore and colleagues noted the FDAs decision to speed the approval of DAAs by reducing the duration of clinical testing from 26 weeks to 12 weeks for some genotypes.
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