Thursday, September 22, 2022

Hepatitis Bs Ab Reactive Means

Does Hepatitis B Show Up In Routine Blood Tests

Understanding Hepatitis B Serology Results

Routine blood tests do not detect hepatitis B virus infection. Hepatitis B tests are specifically done if blood tests show abnormal liver function results, or if a person experiences symptoms or falls into the high-risk category for HBV infection.

A panel of HBV-specific blood tests are required to detect HBV infection.

Also Check: How Much Is Hepatitis A Vaccine

Treatment Options For Hepatitis B

Acute hepatitis B usually doesnt require treatment. Most people will overcome an acute infection on their own. However, rest and hydration will help you recover.

Antiviral medications are used to treat chronic hepatitis B. These help you fight the virus. They may also reduce the risk of future liver complications.

You may need a liver transplant if hepatitis B has severely damaged your liver. A liver transplant means a surgeon will remove your liver and replace it with a donor liver. Most donor livers come from deceased donors.

Can Hbsag And Hbsab Be Positive

Both in vitro simulation and in vivo animal models demonstrated that HBsAg antigen and HBsAb of the same serotypes could not coexist, but HBsAg antigen and HBsAb of different serotype could coexist. HBsAg/HBsAb double positive hepatitis B virus infection could be due to infection of viruses of different serotypes.

Don’t Miss: How Serious Is Hepatitis A

What Does A Reactive Result To A Hepatitis B Test Mean

The meaning of a reactive result for a hepatitis B test depends on the type of test performed, according to the Hepatitis B Foundation. The three most common blood tests detect the presence of hepatitis B surface antigens, hepatitis B surface antibodies or hepatitis B core antibodies.

In the hepatitis B surface antigen test, a reactive or positive result means that a person is currently infected with the hepatitis B virus, explains the Hepatitis B Foundation. Reactive results from the hepatitis B surface antibody test means that people are now immune to the virus because they have been infected in the past and their immune systems produced antibodies to fight the infection. For the hepatitis B core antibody test, a reactive or positive result can mean either that a person is currently infected with hepatitis B virus or have been some time in the test. A reactive result for this test can also be a false positive, meaning that the person has never been infected with the virus.

Hbv Dna Hbv Genotype And Hbv Drug Resistance Assays

Hepatitis B Surface Antibody Ql Reactive Mean

Specimen: Serum or plasma

Container: Red-top tube, yellow-top tube , gel-barrier tube, plasma preparation tube, or lavender tube

Collection method: Routine venipuncture

The specimen should be transfused to separate plasma/serum from cells within 6 hours and kept frozen when testing cannot be done promptly.

The tests use PCR amplification, DNA probe hybridization, and sequencing method.

Don’t Miss: Nofx The Hepatitis Bathtub And Other Stories Audiobook

How Long Can You Live With Hepatitis B

Most people who contract hepatitis B during adulthood fully recover within 1 to 3 months.

People with chronic hepatitis B may have a higher risk of developing long-term liver problems, like cirrhosis or liver cancer, which require treatment and may be life threatening.

Keep in mind that the risk of developing chronic hepatitis B is higher for babies and children, especially if they have not been vaccinated against the virus.

Results And Next Steps

The results of a hepatitis B titer panel can help a doctor determine a persons hepatitis B status. The results can be confusing if a person has never been through this type of testing before, but the doctor can explain the findings.

The results for the titer come back as either negative or positive on each subtest of the panel. Positive means that the virus or antibodies showed up on the test, while negative means that they did not.

The following table outlines what positive and negative results mean on different parts of the test and the possible next steps.

The information comes from the Immunization Action Coalition:

Test

You May Like: Chronic Hep C Without Hepatic Coma Icd 10

Hepatitis B Blood Tests

The Hepatitis B Panel of Blood Tests

Only one sample of blood is needed for a hepatitis B blood test, but the Hepatitis B Panel includes three parts. All three test results are needed to fully understand whether a person is infected or not. Below is an explanation of the 3-part Hepatitis B Panel of blood test results.

  • HBsAg – A “positive” or “reactive” HBsAg test result means that the person is infected with hepatitis B. This test can detect the actual presence of the hepatitis B virus in your blood. If a person tests positive, then further testing is needed to determine if this is a new acute infection or a chronic hepatitis B infection. A positive HBsAg test result means that you are infected and can spread the hepatitis B virus to others through your blood.
  • anti-HBs or HBsAb – A “positive” or “reactive” anti-HBs test result indicates that a person is protected against the hepatitis B virus. This protection can be the result of receiving the hepatitis B vaccine or successfully recovering from a past hepatitis B infection. This test is not routinely included in blood bank screenings. A positive anti-HBs test result means you are immune and protected against the hepatitis B virus and cannot be infected. You are not infected and cannot spread hepatitis B to others.
  • About The Hepatitis B Virus

    Hepatitis B Serology: Surface Antigen (HBsAg), Surface Antibody (anti-HBs), Core Antibody (anti-HBc)

    The hepatitis B virus is a small DNA virus that belongs to the Hepadnaviridae family. Related viruses in this family are also found in woodchucks, ground squirrels, tree squirrels, Peking ducks, and herons.

    Structure of the Hepatitis B Virus The hepatitis B virus contains an outer envelope and an inner core.

    • The outer envelope of the virus is composed of a surface protein called the hepatitis B surface antigen or HBsAg. The HBsAg can be detected by a simple blood test and a positive test result indicates a person is infected with the hepatitis B virus.
    • The inner core of the virus is a protein shell referred to as the hepatitis B core antigen or HBcAg, which contains the hepatitis B virus DNA and enzymes used in viral replication.

    Life Cycle of the Hepatitis B Virus

    The hepatitis B virus has a complex life cycle. The virus enters the host liver cell and is transported into the nucleus of the liver cell. Once inside the nucleus, the viral DNA is transformed into a covalently closed circular DNA , which serves as a template for viral replication . New HBV virus is packaged and leaves the liver cell, with the stable viral cccDNA remaining in the nucleus where it can integrate into the DNA of the host liver cell, as well as continue to create new hepatitis B virus. Although the life cycle is not completely understood, parts of this replicative process are error prone, which accounts for different genotypes or genetic codes of the hepatitis B virus.

    You May Like: First Signs Of Hepatitis C

    Cautions Discusses Conditions That May Cause Diagnostic Confusion Including Improper Specimen Collection And Handling Inappropriate Test Selection And Interfering Substances

    Positive screen results without need for confirmation testing should be interpreted in conjunction with test results of other hepatitis B virus serologic markers .

    Positive hepatitis B surface antigen test results should be reported by the health care provider to the State Department of Health, as required by law in some states.

    Individuals, especially neonates and children, who recently received hepatitis B vaccination may have transient positive HBsAg test results because of the large dose of HBsAg used in the vaccine relative to the individualâs body mass.

    Performance characteristics have not been established for the following specimen characteristics:

    -Grossly icteric

    -Containing particulate matter

    Hepatitis B And Pregnancy

    Hepatitis B can be transmitted from a birthing parent to a newborn infant. This is because the newborn is exposed to blood and bodily fluids during delivery.

    In fact, 90% of mothers with an acute hepatitis B infection and 10% to 20% of mothers with chronic hepatitis B will transmit the virus to their newborn, estimates the American College of Obstetricians and Gynecologists.

    For this reason, birthing parents are routinely screened for hepatitis B during each pregnancy.

    Additionally, the hepatitis B vaccine and hepatitis B immune globulin are both administered to infants with an HBV-positive birthing parent within of birth to prevent infection.

    According to the

    • people with hepatitis C infection
    • men who have sex with men
    • people with multiple sexual partners
    • people who are seeking treatment for a sexually transmitted infections
    • people with current or recent injection drug use
    • family members or sexual partners of those with hepatitis B
    • people with chronic liver disease
    • people traveling to areas with high rates of hepatitis B
    • people on maintenance dialysis
    • people who are incarcerated

    The hepatitis B vaccine is usually administered in three shots, given 1 month and 6 months after the first dose. Another recently approved vaccine is completed in two doses spaced 1 month apart.

    You May Like: Hepatitis C And Treatment Options

    Counseling Practices That Educate Support And Motivate Clients Undergoing Screening

    Clients might need help deciding whether to get screened, understanding the test results, and determining their next steps. Even when services offered through the substance abuse treatment program are limited, discussing testing with clients presents an opportunity for counselors to motivate clients for change by confronting substance use and by making choices that improve their overall health. However, this may also be true when services are offered on-site through substance abuse treatment programs. A study at one methadone clinic that offered hepatitis screening and vaccination revealed that although the majority of clients completed screening , only 54.7 percent of clients who lacked for hepatitis A received vaccinations and only 2.9 percent of clients who lacked immunity for received vaccinations .

    The Consensus Panel makes the following general recommendations while recognizing that, in some programs, the counselors role may be limited:

    What Is The Hepatitis B Virus And What Causes Its Transmission

    Hepatitis C Antibody

    The Hepatitis B virus consists of five types names as A, B, C, D and E. These viruses target the liver. The spread of hepatitis B infection takes place through contact with contaminated bodily fluids such as blood, seminal fluid and vaginal secretions. While the virus cannot spread through mere touch, sneezing or coughing, HBV can spread to others through the use of contaminated needles, illegal drugs, and unprotected sex. An infected mother can pass on the infection to her unborn baby during pregnancy or childbirth. Most patients complain of symptoms of Hepatitis only several weeks after the infection.

    Don’t Miss: What Happens If You Have Hepatitis B

    Hepatitis B Surface Ab Reactive

    Ask U.S. doctors your own question and get educational, text answers â its anonymous and free!

    Ask U.S. doctors your own question and get educational, text answers â its anonymous and free!

    HealthTap doctors are based in the U.S., board certified, and available by text or video.

    Recommended Reading: Hepatitis C Antibody Negative Means

    Transmission Of Hepatitis B

    The hepatitis B virus is transmitted through blood and sexual fluids. This can most commonly occur in the following ways:

    Direct contact with infected blood

    From an infected pregnant person to their newborn during pregnancy and childbirth

    Needles and other medical/dental equipments or procedures that are contaminated or not sterile

    Unprotected sex

    Use of illegal or street drugs

    Body piercing, tattooing, acupuncture and even nail salons are other potential routes of infection unless sterile needles and equipment are used. In addition, sharing sharp instruments such as razors, toothbrushes, nail clippers, earrings and body jewelry can be a source of infection.

    Hepatitis B is NOT transmitted casually. It cannot be spread through toilet seats, doorknobs, sneezing, coughing, hugging or eating meals with someone who is infected with hepatitis B.

    Don’t Miss: Cure For Chronic Hepatitis B

    What Is The Purpose Of A Hepatitis B Test

    Hepatitis B test is performed to detect, classify, and treat hepatitis B virus infection.

    Hepatitis B blood tests involve the measurement of several HBV-specific antigens and antibodies. In addition, HBV blood tests also include liver enzymes and liver function tests to assess and monitor the condition of the liver and provide appropriate treatment.

    The HBV specific tests include the following:

    • HBsAg: HBsAg is an antigen found on the surface of hepatitis B virus. HBsAg may be detected in the blood any time after 1 week post-exposure to HB virus, but usually appears after 4 weeks.
    • Anti-HBs: Anti-HBs are antibodies produced by the bodys immune system to fight HBsAg. Anti-HBs from a prior infection or vaccination provides immunity against further infection.
    • Hepatitis B core antigen : HBcAg is an antigen found in the core layer which covers the hepatitis B viral DNA.
    • Hepatitis B core antibody : Anti-HBc is the antibody that fights HBcAg. Anti-HBc is the first detectable antibody after HBV infection. There are two kinds of Anti-HBc:
    • Immunoglobulin M hepatitis B core antibody : IgM anti-HBc indicates acute or reactivated recent infection within the previous 6 months.
    • Immunoglobulin G hepatitis B core antibody : IgG anti-HBc may indicate previous or chronic infection. Once present, IgG anti-HBc persists for a lifetime.
  • HBV DNA: HBV DNA is the genetic material of the HB virus and this test is a measure of the actual viral load and replication.
  • Addressing Hepatitis For The First Time

    Hepatitis C Infection with Case â Disorders of the Hepatobiliary Tract | Lecturio

    It is crucial that a treatment counselor or health professional use a nonjudgmental and compassionate tone. Clients need to feel comfortable disclosing information about their health and risky behaviors. The following strategies can help initiate the conversation:

    • Display posters, literature, or other -related items that could help prompt the client to ask questions about hepatitis. .
    • Assess clients ability to discuss , based on their degree of openness in the counseling session, the amount of detail they provide in their responses, and the length of the therapeutic relationship.
    • Raise the subject in a way that avoids making clients feel defensive or afraid. Consider introducing the subject by making parallels with other conditions that have been discussed. Say, for example, You said you were tested for HIV several times. Were you ever tested for viral ? or You mentioned that your friend is sick with HIV. Have you been tested for HCV or HIV? Tell me about those tests.
    • Be patient and allow time for multiple, short conversations about the subject. This might ease feelings of fear, anxiety, or shame.

    Don’t Miss: Hepatic Function Panel Blood Test

    What Does It Mean To Have Hep B Antibodies

    Having immunity against hepatitis B results in a positive hepatitis B surface antibody test. 6 It means youve either recovered from the infection or have been successfully vaccinated. When should you be checked to see if you have hep B antibodies?

    How long does it take to get Hepatitis B?

    Hepatitis B is a liver infection caused by the hepatitis B virus. Some people with hepatitis B are sick for only a few weeks , but for others, the disease progresses to a serious, lifelong illness known as chronic hepatitis B. What is acute hepatitis B?

    What are the signs and symptoms of Hep B?

    Hepatitis B signs and symptoms may include: Yellowing of your skin and the whites of your eyes If you know youve been exposed to hepatitis B, contact your doctor immediately. A preventive treatment may reduce your risk of infection if you receive the treatment within 24 hours of exposure to the virus.

    Explainer: Lab Results And Their Interpretation

    Before posting your lab results, please read through and abide by the best practices thread first

    We all know that its important to have blood tests to know your current Hep B status or to know if youre protected against it. There are a lot of different tests in a panel for Hep B and these can be confusing. Here are short explanations for some of the common ones:

    Use this thread to get help if you dont understand your results.

    Hi Everich,

    You need to be a bit more specific about what the exact test was. What is all the information you have about the test? We cannot answer your question without that information.

    Thomas

    Hi Everich, there are basically 3 blood tests that are required for a new vs. a chronic hepatitis B infection. Below is a simple summary of these tests. If you could let us know which blood test was indeterminate that would be very helpful.

    Hepatitis B surface antigen – If or means the hep b virus is present. This could mean a new infection or a chronic infection . If this test is or , then the hep b virus is not present in the blood.

    Hepatitis B surface antibody – this tests for a protective antibody against the hep b virus. This can occur through getting the hep b vaccine or recovery from an exposure to the virus. If or , then it means a person has been protected against the hep b virus either through vaccination or recovery from an infection. Generally, the above test will be or .

    Her report says HBV VIRAL LOAD < 34. IU/ml

    Also Check: Antiviral Drugs For Hepatitis A

    Is Hepatitis B Curable

    Theres currently no known cure for hepatitis B, but there are many ways you can prevent infection and avoid transmitting the virus to others.

    The most effective and safe way to prevent hepatitis B is to get vaccinated. You can also use barrier methods, like condoms, when having sex and avoid sharing needles.

    Question 7 Is Hepatitis B Surface Antibody Antibody Always Acquired After A Completed Vaccination Protocol

    Ppt on hepatitis b

    No. After three intramuscular doses of vaccine, > 90% of healthy adults and > 95% of those < 19 years of age develop immunity .1 However, there is an age-specific decline in development of immunity. After age 40 years, about 90% of people become immune, but by age 60 years, only 75% of people become immune.1 Larger vaccine doses or an increased number of doses are required to induce immunity in many hemodialysis patients and in other immunocompromised people.1

    References

  • Centers for Disease Control and Prevention. Hepatitis B. . Accessed May 30, 2013.
  • Ganem D, Prince AM. Hepatitis B virus infectionnatural history and clinical consequences. N Engl J Med. 2004 350:1118-1129.
  • Don’t Miss: Can You Donate Plasma With Hepatitis C

    Popular Articles
    Related news