Sunday, January 29, 2023

Quantitative Hepatitis B Surface Antibody Titer

Taking A Hepatitis B Test

Hepatitis B Titer – Hep B Surface Antibody Test Results Overview

Testing for hepatitis B is performed on a sample of blood. A doctor, nurse, or other health care provider can obtain a blood sample using a small needle to draw blood from a vein.

At-home hepatitis B testing requires that users carefully follow instructions provided in the test kit to collect a small sample of blood, package the sample, and mail it to a lab for testing.

Read Also: What Is Hepatitis B Surface Antibody

Hepatitis B Blood Tests

The Hepatitis B Panel of Blood Tests

Only one sample of blood is needed for a hepatitis B blood test, but the Hepatitis B Panel includes three parts. All three test results are needed to fully understand whether a person is infected or not. Below is an explanation of the 3-part Hepatitis B Panel of blood test results.

  • HBsAg A positive or reactive HBsAg test result means that the person is infected with hepatitis B. This test can detect the actual presence of the hepatitis B virus in your blood. If a person tests positive, then further testing is needed to determine if this is a new acute infection or a chronic hepatitis B infection. A positive HBsAg test result means that you are infected and can spread the hepatitis B virus to others through your blood.
  • anti-HBs or HBsAb A positive or reactive anti-HBs test result indicates that a person is protected against the hepatitis B virus. This protection can be the result of receiving the hepatitis B vaccine or successfully recovering from a past hepatitis B infection. This test is not routinely included in blood bank screenings. A positive anti-HBs test result means you are immune and protected against the hepatitis B virus and cannot be infected. You are not infected and cannot spread hepatitis B to others.
  • What Is The Purpose Of A Hepatitis B Test

    Hepatitis B test is performed to detect, classify, and treat hepatitis B virus infection.

    Hepatitis B blood tests involve the measurement of several HBV-specific antigens and antibodies. In addition, HBV blood tests also include liver enzymes and liver function tests to assess and monitor the condition of the liver and provide appropriate treatment.

    The HBV specific tests include the following:

    • HBsAg: HBsAg is an antigen found on the surface of hepatitis B virus. HBsAg may be detected in the blood any time after 1 week post-exposure to HB virus, but usually appears after 4 weeks.
    • Anti-HBs: Anti-HBs are antibodies produced by the bodys immune system to fight HBsAg. Anti-HBs from a prior infection or vaccination provides immunity against further infection.
    • Hepatitis B core antigen : HBcAg is an antigen found in the core layer which covers the hepatitis B viral DNA.
    • Hepatitis B core antibody : Anti-HBc is the antibody that fights HBcAg. Anti-HBc is the first detectable antibody after HBV infection. There are two kinds of Anti-HBc:
    • Immunoglobulin M hepatitis B core antibody : IgM anti-HBc indicates acute or reactivated recent infection within the previous 6 months.
    • Immunoglobulin G hepatitis B core antibody : IgG anti-HBc may indicate previous or chronic infection. Once present, IgG anti-HBc persists for a lifetime.
  • HBV DNA: HBV DNA is the genetic material of the HB virus and this test is a measure of the actual viral load and replication.
  • Read Also: How To Test For Hepatitis

    Sequence Following An Initial Negative Hepatitis B Surface Antibody Titer

    As you obtain documentation, please submit documentation of each step to CastleBranch

    • Initial Hepatitis B titer negative for immunity
    • Receive Hepatitis B challenge dose/booster
    • Repeat Hepatitis B titer 4-6 weeks after challenge/booster vaccine
  • If Repeat Hepatitis B titer is positive for immunity requirement will be marked Complete
  • If Repeat Hepatitis B titer is negative for immunity
  • Receive the remainder of the vaccines in the Hepatitis B vaccine series
  • If challenge dose/booster was Engerix-B or Recombivax HB
  • 2 additional vaccines are needed
  • Receive one as soon as possible after you receive notice that the repeat titer is negative
  • Receive final vaccine 5-6 months after the challenge dose/booster.
  • If challenge dose/booster was Heplisav-B
  • 1 additional vaccine is needed
  • Receive as soon as possible after you receive notice that the repeat titer was negative.
  • Question 5 What Is The Natural History Of Hepatitis B Surface Antibody During Acute Hepatitis B Infection And Convalescence

    (Hep B Titer) HBV Surface, antibody Quantitative Test.  LabReqs.com

    HBsAg can be detected in the blood 4 to 10 weeks after exposure. This corresponds to onset of symptoms and viremia detectable by nucleic acid amplification methods. Most hepatitis B infections are self-limited and are associated with disappearance of HBsAg within 4 weeks of onset of symptoms. The anti-HBs then appears and increases to a plateau level that persists indefinitely.2

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    How To Get Tested

    Hepatitis B testing is typically prescribed by a doctor and performed in a hospital, lab, or other medical setting. Taking a hepatitis B test requires a blood sample, which can be collected by a health care professional.

    For laboratory-based testing, blood is drawn from a patients vein. After blood is collected, the sample is sent to a laboratory for analysis.

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    Comparison Of Qhbcab And Qhbsag At Baseline Using Kaplan

    Figures 4A, B show the comparison of HBsAg recurrence rates at the time of the last follow-up by Kaplan-Meier method. Patients who experienced high a risk of HBsAg recurrence had lower qHBcAb and higher qHBsAg levels than those who achieved sustained HBsAg loss .

    Figure 4 The Kaplan-Meier curve of HBsAg conversion rates at the last time of follow-up. The proportion of patients with sustained HBsAg loss according to qHBcAb at baseline. The proportion of patients with sustained HBsAg loss according to qHBsAg at baseline.

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    Qhbcab And Qhbsag As Predictors Of Hbsag Recurrence

    The ability of qHBcAb and qHBsAg at baseline to predict HBsAg recurrence was analyzed using ROC curves to compare HBsAg recurrence and sustained HBsAg loss groups . The area under the curves of qHBcAb and qHBsAg were 0.685 and 0.651 , respectively. Using the Youden index , we predicted that when qHBcAb was higher than 4.25 log10 IU/mL and qHBsAg was lower than 2.82 log10 IU/mL, sustained HBsAg loss would occur more readily after LT.

    Figure 2 QHBcAb and qHBsAg as predictors of HBsAg recurrence. . Receiver operating characteristic analyses of qHBcAb and qHBsAg as predictors of HBsAg recurrence at baseline. . Curves of the specificity, sensitivity and Youden index for qHBcAb and qHBsAg. The position of the black vertical dotted line shows the maximum Youden index that was used to predict HBsAg recurrence.

    Does Hepatitis B Show Up In Routine Blood Tests

    Understanding Hepatitis B Serology Results

    Routine blood tests do not detect hepatitis B virus infection. Hepatitis B tests are specifically done if blood tests show abnormal liver function results, or if a person experiences symptoms or falls into the high-risk category for HBV infection.

    A panel of HBV-specific blood tests are required to detect HBV infection.

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    Hepatitis B Surface Antibody Quantitative

    The Hepatitis B Panel of Blood Tests

    Only one sample of blood is needed for a hepatitis B blood test, but the Hepatitis B Panel includes three parts. All three test results are needed to fully understand whether a person is infected or not. Below is an explanation of the 3-part Hepatitis B Panel of blood test results.

  • HBsAg A positive or reactive HBsAg test result means that the person is infected with hepatitis B. This test can detect the actual presence of the hepatitis B virus in your blood. If a person tests positive, then further testing is needed to determine if this is a new acute infection or a chronic hepatitis B infection. A positive HBsAg test result means that you are infected and can spread the hepatitis B virus to others through your blood.
  • anti-HBs or HBsAb A positive or reactive anti-HBs test result indicates that a person is protected against the hepatitis B virus. This protection can be the result of receiving the hepatitis B vaccine or successfully recovering from a past hepatitis B infection. This test is not routinely included in blood bank screenings. A positive anti-HBs test result means you are immune and protected against the hepatitis B virus and cannot be infected. You are not infected and cannot spread hepatitis B to others.
  • Hepatitis B Surface Antibody

    Hepatitis B Surface Antibody
    Description

    The Quantitative detection Hepatitis B virus Surface IgG antibody in human sera using the FDA approved Abbott ARCHITECT AUSAB-DIL test two-step chemiluminescent immunoassay.

    In the first step, sample, assay diluent, and recombinant Hepatitis B surface Antigen coated paramagnetic microparticles are combined. Anti-HBs present in the sample binds to the rHBsAg coated microparticles. In the second step, rHBsAg acridinium-labeled conjugate is added, which binds to IgG anti-HBs. Then pre-trigger and trigger solutions are added to the reaction mixture. The resulting chemiluminescent reaction is measured as relative light units .

    A direct relationship exists between the amount of anti-HBs in the sample and the RLUs. The concentration of anti-HBs in the sample is determined using an active ARCHITECT AUSAB calibration curve. Results are reported as mIU/mL.

    For Batteries containing HBSAb see:

    Hepatitis B Antibodies , Quantitative detection of Hepatitis B virus Surface IgG antibody and Hepatitis B virus Core IgG and IgM antibodies

    Hepatitis B Battery , Quantitative detection of Hepatitis B virus Surface IgG antibody , Qualitative detection of Hepatitis B virus Surface Antigen and Qualitative detection of Hepatitis B virus Core IgG and IgM antibodies

    Hepatitis B Surface Antigen & Antibody , Quantitative detection of Hepatitis B virus Surface IgG antibody and Qualitative detection of Hepatitis B virus Surface Antigen

    Synonyms

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    Hepatitis B Surface Antibody Titer

    SKU:

    This antibody titer test checks for immunity to Hepatitis B.

    Hepatitis B Surface Antibody Titer This test measures your Hepatitis B Surface Antibody IgG titer level.

    Most people receive the Hepatitis B vaccine series when they are young and/or receive vaccine boosters as adults. As a consequence of either vaccination or prior exposure, people develop antibodies to Hepatitis B.

    The Hepatitis B Titer Test measures the Hepatitis B IgG antibody levels in your blood. Positive results mean that you are considered immune to Hepatitis B according to accepted international standards.

    Hepatitis B Titer Test results are reported as quantitative IgG titers.

    This information is for educational purposes only, and does not constitute medical advice, diagnosis or treatment in any way. This site does not replace the services of licensed health care professionals and all site users should consult with a physician regarding their health concerns.

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    Measurement Of Qhbcab Concentration In Serum

    What is the hepatitis B surface antibody?

    The qHBcAb level in serum was measured using a newly developed double-sandwich immunoassay , calibrated using the World Health Organization standard . QHBcAb was measured at baseline, with the sought time of HBsAgpositive status before LT being at least two weeks, and then at different time points after LT.

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    Question 2 What Is The Hepatitis B Surface Antibody

    The hepatitis B surface antibody is the antibody that is produced in response to hepatitis B surface antigen , a protein present on the surface of the hepatitis B virus. Anti-HBs appears after convalescence from acute infection and lasts for many years. It can also be produced in response to hepatitis B vaccination.

    Other hepatitis B antibodies are not produced in response to vaccination. This is because these antigens are not in the vaccine.

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    Correlation Between The Anti

    No new HBsAg carrier was detected during the follow-up period. Follow-up serum specimens obtained from 876, 788, and 197 subjects at 13, 14, and 15 years of age, respectively, were tested for anti-HBs levels by both EIA and RIA. The EIA titers and the RIA S/Ns of anti-HBs were compared for each participant thus, 1,861 pairs of data for 922 participants ages 13 to 15 years were collected. The correlation between the anti-HBs levels measured by RIA and EIA were assessed by a scatter plot. There was a good correlation between the serum anti-HBs levels measured by the RIA and the EIA methods .1). A linear regression equation of RIA to EIA level conversion was formulated as follows: log EIA titer =0.12 + .

    Correlation between the anti-HBs levels tested by RIA versus EIA in 1,861 serum samples.

    Measurement Of Qhbsag Qhbeag Hbcab And Hbv Dna Concentrations In The Serum

    Quantitative HBsAg and its Role in Chronic Hepatitis B Patient Management

    Serum levels of qHBsAg, qHBeAg and HBcAb were measured using a chemiluminescence microparticle immunoassay on an Abbott Architect I4000 automated analyzer . HBV DNA levels in serum were measured using Qiagen PCR kits on ABI 7500 qRT-PCR System according to the manufacturers instructions. The linear detection range was 3 – 7 log10 IU/mL, with a correlation coefficient of the standard curve > 0.995. Biomarkers were measured before LT and at different time points after LT.

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    Whats The Hepatitis B Titer Test Used For

    A hepatitis B titer test measures antibodies in your blood to see if youre immune either due to vaccination or previous infection.

    Hepatitis B is a viral infection that targets your liver. It can be transmitted by coming into contact with the bodily fluids of an infected person. A person with the virus can also infect their child during birth.

    Hepatitis B can develop into a chronic infection. Chronic infection occurs when your body cant fight off the virus within six months. Chronic hepatitis B infections most commonly develop less than six years old, especially in infants.

    Hepatitis B titer tests can be used to evaluate:

    • whether a high-risk person is immune to hepatitis B
    • whether hepatitis B immunoglobulin is needed after a needle prick
    • men who have sex with men
    • people born in countries with a hepatitis B prevalence greater than 2 percent
    • people born in the United States not vaccinated as children and with parents born in regions with more than 8 percent hepatitis B prevalence

    You may need your titer test results as proof of hepatitis B immunity in order to get into healthcare programs at many schools for example, the nursing program at Lone Star College. In the United States, employers are not allowed to withdraw a job offer if they learn you have hepatitis B.

    What Is The Normal Range For Hepatitis B Surface Antibody

  • What Is the Normal Range for Hepatitis B Surface Antibody? Center
  • Hepatitis B surface antibodies are measured in blood samples in milli-International Units/milliliter mIU/mL). The ranges for hepatitis B surface antibodies are:

    • Anti-HBs greater than 10-12 mIU/mL: Protected against hepatitis B virus infection, either from vaccination or successful recovery from a previous HBV infection.
    • Anti-HBs less than 5 mIU/mL: Negative for HBV infection, but susceptible and hence requires vaccination.
    • Anti-HBs from 5-12 mIU/mL: Inconclusive results and the test should be repeated.

    However, there is no standardization of these values so it is advisable to check the manufacturers values it is the reason values are mainly reported as positive or negative.

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    Understanding Of Lab Tests Results

    Please visit the site associated with The American Association for Clinical Chemistry for better understanding of tests. There you will find the most detailed and full information regarding lab tests. In common questions tab you will find answers on the most common questions.

    In addition, you can use a special form to ask the question. It is useful, if there is no answer on your question on the web site. A laboratory scientist will answer your question. It is a part of voluntary service provided by the American Society for Clinical Laboratory Science.

    Very Easy And Quick Result

    Hepatitis B Foundation: Understanding Your Hepatitis B Test Results

    Very satisified with my experience. Went to the website and choose my test, got the prescription thru email with in 30 minutes. Got blood draw the following morning at Lab Corp. Then got the result the following day thru secured emai link. Thats only 48 hrs from log in to result. Compared to my MD office which is 10 days to get the result and after multiple calls and only to find out that they performed a wrong lab test. Here you know what test they are performing since you are the one choosing.

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