A Traditional Chinese Medicine Maoto Suppresses Hepatitis B Virus Production
- 1Division of Virology, Department of Microbiology and Immunology, Osaka University Graduate School of Medicine, Osaka, Japan
- 2Department of Microbiology, Noakhali Science and Technology University, Noakhali, Bangladesh
Worldwide, millions of people suffer from hepatitis B virus infection, putting them at a high risk of death from liver cirrhosis and cancer. Although effective anti-HBV drugs have been developed, current drugs have some limitations, as most of them have a risk of significant side effects. Therefore, the discovery of safe and effective anti-HBV drugs is still needed. Natural compounds are considered sources of novel, safe and effective therapeutics. In this study, we screened a library of Kampos, traditional herbal medicines, for suppression of HBV production. Among them, we found that maoto reduced extracellular HBV DNA but not extracellular HBsAg during HBV infection, suggesting that it suppressed HBV production by interfering with HBV nucleocapsid incorporation into viral particles. Furthermore, we revealed that maoto reduced the expression of a host gene, Tropomyosin chain , whose downregulation also suppressed HBV production, similarly to maoto. Since the safety of maoto has been already confirmed, maoto can be considered a candidate anti-HBV agent if the effect is confirmed in vivo. In addition, our findings also suggest TPM2 as a novel molecular target for the development of anti-HBV agents.
Ampalaya Or Bitter Gourd
A very popular vegetable in the Philippines, it is eaten along with fish dishes or plainly sauteed. Known as one of the King of Bitters, this Philippine herbal medicine has been found to be effective in the treatment of diabetes , hemorrhoids, coughs, burns and scalds, and being studied for anti-cancer properties.
Even the leaves has curative effects and is said to affect alleviate rheumatism and gout. But it is known more as a food supplement for diabetic patients and lowering of blood sugar and blood pressure levels. Ampalaya is also available in capsule and is commercially available as tea.
Ampalaya is best for: Diabetics
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Results Of One Chinese Clinical Trial
In a clinical trial carried out at three test sites in China, there were 94 inpatients treated and evaluated, utilizing three therapies . The main test therapy was the formula now called Salvia/Ligustrum Tablets, taken with the vitamin tablet. The primary control therapy was a tablet of the same size and same dosage made with lentinus extract , atractylodes, and schizandra the control patients also took the vitamin supplement. The third control group took a patent medicine made in China that was understood, by the Chinese researchers, to be the most effective one available.
As a result of 12 weeks treatment, in the Salvia/Ligustrum group and the Lentinus group there was marked improvement in symptoms and liver enzymes, more so than with the Chinese patent remedy. Antigen conversion from positive to negative occurred for HBeAg in 2/3 of patients treated by Salvia/Ligustrum or Lentinus Tablets, but in only 1/3 of those receiving the Chinese patent. HBsAg conversion occurred only in a few patients, 2 receiving Salvia/Ligustrum, 1 receiving Lentinus, and none receiving the Chinese patent. Nearly half of those tested showed viral DNA conversion from positive to negative in those receiving Salvia/Ligustrum, and in one-third of those receiving Lentinus, but only in about one-fourth of those receiving the Chinese patent.
Filipino Doctors And Hep C Treatment
Nowadays a lot of my work is helping people in poor countries, such as the Philippines and Nigeria, to access Hepatitis C treatment. One of the barriers that I come up against is that many doctors in these countries do not understand Hepatitis C or its treatment.
Lately I have had a number of examples of doctors from poorer countries prescribing totally the wrong medication for the treatment of Hep C.
Whilst I am not a doctor I do know quite a lot about Hep C and Hep C treatment and am happy to share this information for free.
Below is an example of what I am talking about. A Filipino person has written to me asking for advice after their doctor prescribed Interferon to treat their Hep C.
Subject: Inquire about Medicines for HCV
Good Day Sir Greg
My doctor prescribed medicine for my HVC, in case when I was going to buy the medicine at the Mercury Drug Store, it was said that the medicine had been theirs since 2010.
Thats the name of the medicine I prescribed.
What is the possible replacement for that?
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Tropomyosin Chain Supports Extracellular Hepatitis B Virus Production
Figure 5 Tropomyosin chain knockdown decreases hepatitis B virus production. TPM2 mRNA in maoto-treated cells. HepG2-NTCP cells were treated with distilled water or concentrations of 1.5625, 6.25, 25, and 100 µg/ml of maoto extract for 9 days. The amount of TPM2 mRNA was measured by real-time RT-PCR. Schematic representation of the protocol of maoto treatment and transfection of an HBV-expressing plasmid together with an sh-TPM2-expressing plasmid in HepG2 cells. The remaining plasmids were washed at 6 h after the transfection and the medium was refreshed . The medium was further refreshed at 3 days after the transfection . TPM2 mRNA in sh-TPM2-expressing cells. Knockdown of TPM2 was confirmed at 7 days after the transfection by real-time RT-PCR. Effect of TPM2 knockdown on HBV production. HBV DNA in culture supernatants of the cells was measured by real-time PCR and normalized with the transfection efficiency based on luciferase activity of the cells. Lamivudine was used as a positive control for the inhibition of HBV production. Effect of maoto extract on HBV production in sh-TPM2-expressing cells. Values are expressed as the mean percentage + S.E. of three independent experiments. *P< 0.05 **P< 0.01 ****P< 0.001 N.S., no significance.
Herbal Remedies And Supplements
Many people are interested in using herbal remedies or supplements to boost their immune systems and help their livers. The problem though is that there is no regulation of companies manufacturing these produces, which means there is no rigorous testing for safety or purity. So the quality of the herbal remedy or vitamin supplement may be different from bottle to bottle. Also some herbal remedies could interfere with your prescription drugs for hepatitis B or other conditions some can even actually damage your liver.
There are many companies that make false promises on the Internet and through social media about their products. Online claims and patient testimonials on Facebook are fake and are used to trick people into buying expensive herbal remedies and supplements. Remember, if it sounds too good to be true, then its probably not true.
Below are reliable sources of information about herbs and alternative medicines. This information is based on scientific evidence, not false promises. Check whether the active ingredients in your herbal remedies or supplements are real and if it safe for your liver. The most important thing is to protect your liver from any additional injury or harm.
U.S. National Institutes of Health National Center for Complementary Medicine and Integrative Health
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Banaba Or Giant Crape Myrtle
Although not listed in the recommended herbal plants, it is a very popular Philippine herbal plant leaves used to treat diabetes and kidney failure, obesity and high fever. It is popular in other countries such as India where it is used to treat diabetes. Its leaves and flowers contain corrosolic acid, a substance being studied for its insulin like effect of lowering the glucose in the body. Also used for weight loss it is rich in vitamins and minerals as well as dietary fibers.
Folkloric uses of Banaba herbal medicine include the treatment for diarrhea, constipation, inflammation of kidneys, dysuria and other urinary dysfunctions. The Banaba leave can be boiled and drank as a tea.
Banaba is best for: Kidney health
DISCLAIMER: This article is based on scholarly articles from Wikipedia, the Department of Health, and long-held traditional knowledge of this folk medicines. Laminine is not related nor its ingredient has any of these plants, thus it is not an herbal supplement. This article merely reflects what some herb plants may do to the body.
Silybum And Its Component Silymarin
Silymarin is a complex flavonoid from Silybum marianum, an herb that was initially introduced as a therapeutic agent by European researchers, but soon taken up by their counterparts in China as a treatment for liver diseases. Its main action is to protect the liver from damage, and it is used, for example, in the early stage of liver destruction due to ingestion of poisonous mushrooms, to save the lives of victims. A concentrated extract of silybum, rich in silymarin, is sold as a health product in the U.S. and the isolate has been sold as a drug in Europe for the treatment of liver disease for the past 15 years. A dosage of 140 mg/day is reported to be liver protective and a dosage of 420 mg/day is reported to help repair liver damage. It is not clear that silymarin can cure viral hepatitis. Silybum extracts are widely sold as health foods in the United States.
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What Should You Eat When You Have Hepatitis B
A bad diet contains many toxins which can further worsen the hepatitis infection. Bad habits such as excess alcohol consumption can damage your liver and spreads the infection more. A good diet and healthy lifestyle help to bring your health back and actually improves liver function and lowered risk of liver cirrhosis. So you should opt for a healthy lifestyle and avoids all the things which we will mention in the next heading.
- Plenty of fruits and vegetables
- Eat lots of protein-rich food such as fish, skinless chicken, egg white and beans.
- Low-fat dairy products
- Add whole grains such as pats, brown rice, barley, and quinoa in your diet.
- Add healthy fats like nuts, avocado, olive oil in your daily routine.
Ligustrum And Its Component Oleanolic Acid
Ligustrum refers to the seed of Ligustrum lucidum. It is rich in oleanolic acid, a compound that appears to be effective in treatment of liver diseases, acting mainly as a liver-protective agent. It is reported to be efficacious in treating both acute and chronic hepatitis, with a cure rate of 70% for acute hepatitis and it was markedly effective in treating 44% of cases of chronic hepatitis. Ligustrum has been identified as one of the herbs that strongly enhances immune responses, reversing leukopenia from cancer therapeutic agents. Ligustrum is used as a health food in the U.S. to enhance immune functions.
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Akapulko Or Ringworm Bush Or Acapulco
Also known as Bayabas-Bayabasan, Akapulko is used to treat tinea infections, insect bites, ringworms, eczema, scabies, and itchiness. The leaves can be pounded and its extract directly applied to the affected skin problem. The leaves contain chrysophanic acid, a fungicide that is used to treat fungal or skin infections. The leaves extract can also be used in homemade soaps, shampoos, and lotions.
Akapulko is best for: Relieving scabies or insect bites.
Transient Hepatitis B Virus Production
HepG2 cells were cotransfected with pHBI together with pGL3 to normalize the transfection efficiency and an shRNA-expressing plasmid using GenJet In Vitro DNA Transfection Reagent according to the manufacturers instructions. At 7 days post-transfection, the culture supernatant was used to measure the level of HBV production by real-time PCR, and cell lysates were used to check the transfection efficiency by a Luciferase Assay System .
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Study Design And Setting
The study was conducted within the gastroenterology clinic of Mulago hospital, a tertiary teaching and National Referral Hospital, in Kampala which handles up to 100 adult patients weekly on average with either luminal gastrointestinal issues or liver/pancreatic conditions. The study specifically targeted patients who had a known diagnosis of liver inflammation due to different causes such as hepatitis B virus, hepatitis C virus, drug-induced and alcohol-induced inflammation as shown on their medical records. Data was collected using standardized questionnaires followed by focus group discussions on a sample of patients. The questionnaires used were modified from the International Questionnaire to Measure Use of Complementary and Alternative Medicine .
European Commission And Thervacb Join Forces
The role of viral hepatitis as a public health threat has long been underestimated. Only very recently, the United Nations in their 2030 Agenda for Sustainable Development called for international action to combat viral hepatitis and reduce the disease burden. The major killer is the hepatitis B virus causing liver cirrhosis and liver cancer. Worldwide 880,000 humans die each year from the consequences of an HBV infection.
A prophylactic vaccine is available to prevent HBV infection, but more than 3% of the worlds population are chronically infected and do not profit from that vaccine anymore. For those suffering from chronic hepatitis B, until today no curative treatment option exists.
The European Commission therefore selected the project TherVacB led by Helmholtz Zentrum München for a five-year funding within the Horizon 2020 program. A consortium of leading virologists, immunologists and physicians specialized in treating viral hepatitis, will use a newly designed therapeutic vaccine, TherVacB, as an immunotherapy to cure HBV. TherVacB will be evaluated in a three-year clinical trial starting in 2022 conducted in Europe and in Africa. Integration of a partner site in Tanzania shall help building local capacities for diagnosing and treating hepatitis B and support an important goal of the consortium to raise awareness for hepatitis B.
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Natural Remedies And Hepatitis B
When we get sick, we want to get well quickly. Some of us turn to our doctors first, while others may try home remedies or alternative medicine. Many of us do both.
Natural medicine means that no chemicals, drugs or surgeries are used to help you get well. Alternative medicine is simply an alternative to conventional medicine. For instance, in the U.S., ancient healing practices, such as faith healing, Chinese medicine or seeing a curandero are alternatives. So are naturopathy, homeopathy, and herbal medicine. Integrative medicine uses both. Its common for people to use more than one healing method.
In the U.S., we have access to many alternatives, and we tend to apply Western medical concepts to natural medicine. This is most evident in our use of supplements. When diagnosed with hepatitis B, we may want to take something that will help the liver, such as a supplement or herb. Its easier to take something than it is to exercise and eat right. However, everything passes through the liver, and just because herbs and supplements are natural, they arent necessarily safe.
Despite claims on the Internet, no natural remedy has been proven to cure hepatitis B. There may be remedies that improve symptoms associated with hep B, but none has permanently eradicated the virus. There isnt a large body of research on natural remedies and hepatitis B much of what we know is anecdotal, meaning that people tell others about their experiences.
Ayurvedic Medicines For Hepatitis B By Planet Ayurveda
Planet Ayurveda has provided us with an herbal combo pack known as “Liver Care pack”, which contains a blend of various natural herbs. It is free from any harmful preservative, additive and chemical compounds. The all the products of Liver Care Pack contains natural extract of herb such as Indian Echinacea, Bhumi Amla , Katuki , Makoy , Punarnava , Kaasni , Bhringraj etc.
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How Is It Currently Treated
There is no cure for chronic hepatitis B virus.
In most cases, treatment requires taking a pill every day for life to remain effective and to reduce the risk of liver cancer. Even then, it doesnt eliminate the risk.
Chronic hepatitis B hasnt been cured so far in part because current therapies have failed to destroy the viral reservoir, where the virus hides in the cell.
This is in contrast to hepatitis C virus, which has no such viral reservoir and can now be cured with as little as 12 weeks of treatment.
Despite the huge human and economic toll of chronic hepatitis B, research to cure the disease remains underfunded. There is a misconception that because there is a vaccine, hepatitis B is no longer a problem.
The availability of effective cures for the unrelated hepatitis C virus has also led people to believe that viral hepatitis is no longer a problem.